Slide 1: Delivering the Power of Sight
Delivering the Power of Sight Investor Presentation May 2022 ™
Slide 2: Forward Looking Statements
1 Forward Looking Statements This presentation, together with other statements and information publicly disseminated by the Company, contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act
Slide 3: Our Mission
2 Transform Ophthalmology and Optometry through products that target the underlying causes of the world’s most prevalent eye diseases Establish new treatment paradigms and create an interventional mindset in Eyecare to replace conventional outdated approaches Our Mission Goal: Products that Restore
Slide 4: Current Product Portfolio
CURRENT PRODUCT PORTFOLIO Additional products in development to build comprehensive portfolio of POAG and DED treatment options Glaucoma is #1 cause of irreversible blindness Microinvasive Glaucoma Surgery (MIGS) is the leading innovation in POAG treatment Underdeveloped Standalone MIGS segment repr
Slide 5: Strategic Value Creation Initiatives
Strategic Value Creation Initiatives Expand Presence in Established Combination Cataract MIGS Segment in POAG Continue gaining adoption among existing base of >5,600 MIGS-trained surgeons Continue penetrating Combination Cataract segment by leveraging the ability of OMNI® to address all three points
Slide 6: Primary Open-Angle Glaucoma (POAG)
Primary Open-Angle Glaucoma (POAG) ™
Slide 7: OMNI: Broad FDA-Cleared Indication for Use
5 OMNI®: Broad FDA-Cleared Indication for Use OMNI enables two sequential, ab interno MIGS procedures in adults with POAG – intuitive, minimally invasive, performed through a single clear corneal microincision, and each titratable up to 360° Trabeculotomy using OMNI Canaloplasty using OMNI “for cana
Slide 8: OMNI Addresses the 3 Primary Points of Resistance
We believe (i) there is NO diagnostic to determine where the resistance is in the conventional outflow pathway and (ii) OMNI® is singularly well-suited to address all 3 primary points of resistance OMNI® Addresses the 3 Primary Points of Resistance 1 2 3 TRABECULAR MESHWORK SCHLEMM’S CANAL DISTAL CO
Slide 9: Enabling an Interventional Mindset in POAG
Enabling an Interventional Mindset in POAG PRESCRIPTION MEDICATIONS Surgeons can use OMNI® to intervene across a broad population of POAG patients STANDALONE (>85%1 of POAG; ~5.4M eyes) COMBINATION CATARACT (<15%1; ~0.8M eyes) CONVENTIONAL TREATMENTS TRABECULAR BYPASS STENTS LASER TRABECULOPLASTY CO
Slide 10: OMNI is Titratable to All MIGS Categories in POAG
OMNI® is Titratable to All 6 MIGS Categories in POAG Low Risk of Hyphema Consistency of Efficacy Degree of Efficacy Represents estimated % of U.S. POAG TAM The FDA granted an investigational device exemption authorizing our PRECISION RCT to assess the safety and effectiveness of a canaloplasty alone
Slide 11: OMNI Outpacing Growth of Overall Canaloplasty Claims
11 OMNI Outpacing Growth Of Overall Canaloplasty Claims Gaining Penetration in Combination Cataract 2018-21 CAGRs 66984 + All MIGS Codes: 17% 66984 + Canaloplasty: 81% 2018-21 CAGR 122% 2018-21 CAGR 71% Canaloplasty Claims Growing In Combination Cataract MIGS 1. Includes 66174 Canaloplasty, 65820 Tr
Slide 12: Pieces in place to deliver the benefits of Standalone
Pieces in place to deliver the benefits of Standalone Broadest label and most comprehensive treatment of conventional outflow pathway Significant investment in clinical trials, including 3 OMNI superiority RCTs versus existing treatments Glaucoma Clinical Consultants educating POAG community Signifi
Slide 13: Canaloplasty Propelling Standalone MIGS
Canaloplasty Propelling Standalone MIGS Standalone Canaloplasty claims have more than doubled since 2018; claims for the other top Standalone glaucoma codes declining Standalone Canaloplasty claims driving growth of all Standalone MIGS; included in almost one-half of Standalone MIGS claims 2H2021 20
Slide 14: Developing the Standalone MIGS POAG Segment
85% of glaucoma patients would be likely to get a Standalone intervention with OMNI if recommended by their doctor1 Developing the Standalone MIGS POAG Segment Convert >5,600 MIGS-Trained Surgeons to OMNI Exceptional customer experience; hands-on training in dry labs and OR ~1,600 surgeons trained t
Slide 15: OMNI Clinical Trials: Completed, Ongoing and Planned
ROMEO (Completed) GEMINI (Completed) 8 Ongoing and Planned Trials Goals 12-month multi-center retrospective real world study Elevated baseline IOP group: significant reduction in IOP and medications Controlled baseline IOP group: IOP controlled, significant reduction in medications Compelling and co
Slide 16: Recent and Anticipated OMNI Clinical Milestones
19 Recent and Anticipated OMNI® Clinical Milestones 16 presentations planned for Ophthalmic Congresses in 2022; Active investigator initiated trial (IIT) program 2022 Q1 TRIDENT: first patient treated GEMINI: OMNI procedures in Hispanic eyes published in Clinical Ophthalmology 2022 2Q Plan PRECISION
Slide 17: TearCare Dry Eye Disease
— © Tearcare —_—_— —_ areguee, O ae Dry TearCa Eve DISEASE Wed System
Slide 18: Dry Eye Disease and Meibomian Gland Dysfunction
Dry Eye Disease and Meibomian Gland Dysfunction MEIBOMIAN GLANDS Dry Eye Disease (DED) can be extremely painful and can lead to permanent cornea damage and vision impairment MGD is present in the vast majority of diagnosed dry eye cases, linked to many prominent demographic, medical and sociological
Slide 19: Our Solution: TearCare
Our Solution: TearCare® The Only Open-Eye Heat + Expression device designed to melt + remove meibomian gland obstructions Intuitive Design Designed for intuitive provider training and comfortable patient experience SmartLids™ are designed to conform to variable eyelid anatomy and heat glands to a pr
Slide 20: New TearCare IFU Cleared by FDA December 2021
New TearCare® IFU Cleared by FDA December 2021 December 2021 Indication for Use “For the application of localized heat therapy in adult patients with evaporative DED due to MGD, when used in conjunction with manual expression of the meibomian glands” Considerable benefits from expanded indication fo
Slide 21: Support Patient Access Strategy with Expanded Label and RCT Data
1 Support Patient Access Strategy with Expanded Label and RCT Clinical Data vs. Rx Clinical and real-world data intended to support coverage, coding and payment Payor research: conducted eight 1:1s with medical directors from national and regional payors for feedback on our clinical programs (e.g.,
Slide 22: TearCare Clinical Program Summary
TearCare® Clinical Program Summary OLYMPIA RCT (Completed) Head-to-head versus MGD device (LipiFlow®) Objective: To study effectiveness and safety of the TearCare System compared to LipiFlow in reducing the signs and symptoms of DED Prospective multi‐center (10 sites), randomized controlled, masked
Slide 23: TearCare Clinical Milestones & Timeline
TearCare® Clinical Milestones & Timeline Note: Clinical trials, including their design, endpoints and timing, are subject to change at the Company’s discretion. Initial results may include preliminary data and interim analyses that are subject to change. 10 presentations planned for Ophthalmic Congr
Slide 24: TearCare Controlled Release
TearCare® Controlled Release - Executing a controlled release of TearCare with ~10 direct outside sales reps since April 2019 (expanded to ~15 in late Q4 2021) - Successful patient-pay adoption Over 600 facilities added (through 3/31/21); sizable base of steady reordering accounts Messaging focused
Slide 25: New Product Overview
Delivering the Power of Sight NEw PRODUCT OVERVIEW
Slide 26: Our Product Development Process
Four fundamental requirements to deliver consistent, effective and safe outcomes for patients Our Product Development Process Comprehensive Understanding of Disease Physiology Analyze available clinical data, science and literature to achieve sound understanding of disease Address the Underlying Cau
Slide 27: Leverage Sight's Proven Development Expertise and Commercial Infrastructure
Our product development initiatives further leverage: An unparalleled clinical understanding of the underlying causes of glaucoma & dry eye A differentiated and efficient development process Ongoing and substantial investment in specialized Sales, Marketing, Clinical and Market Access resources that
Slide 28: Lead the Glaucoma and Dry Eye Disease Categories
Lead the Glaucoma and Dry Eye Disease Categories Portfolio will treat all severities of disease, ranging from mild to advanced Product suite will address the full continuum of care in tomorrow’s treatment paradigm + Portfolio will offer each of OTC, Sustained Rx, and Devices/Procedures Ability to tr
Slide 29: Offer a Comprehensive Portfolio of Six Products
Offer a Comprehensive Portfolio of Six Products GLAUCOMA PRODUCT DEVELOPMENT OVERVIEW 4. FDA-cleared canaloplasty followed by trabeculotomy 5. Canaloplasty alone IDE trial underway MILD TO MODERATE DISEASE In-office Injection of Sustained Release Pharmaceutical (Rx) 1 MILD TO MODERATE DISEASE OR Per
Slide 30: Offer a Comprehensive Portfolio of Four Products
Over-the-counter Artificial Tear With A Differentiated Lipid Layer Technology Dry Eye Disease Prescription Pharmaceutical Eyelid Ointment Office-Based Eyelid Procedure Home-Based Eyelid Device Treatment 1 2 4 Offer a Comprehensive Portfolio of Four Products DRY EYE DISEASE PRODUCT DEVELOPMENT OVERVI
Slide 31: Financial Overview
Delivering the Power of Sight FINANCIAL OVERVIEW
Slide 32: 1Q22 Highlights
1Q22 Highlights 1Q revenue $14.9M Surgical Glaucoma $13.9M Dry Eye $1.0M 1Q YoY revenue growth Surgical Glaucoma: 70% Dry Eye: 104% Total: 72% 1Q gross margins Surgical Glaucoma: 89% Dry Eye: (53%) Total: 80% FY22 Guidance: $67MM to $75MM (37% to 53% growth over FY21) $238.6M of cash on hand at 3/31
Slide 33: Appendix
Delivering the Power of Sight APPENDIX
Slide 34: OMNI Clinical Timeline
OMNI® Clinical Timeline Note: Clinical trials, including their design, endpoints and timing, are subject to change at the Company’s discretion. Initial results may include preliminary data and interim analyses that are subject to change. 28
Slide 35: CMS Final Payment Rules 2022 vs. 2021
CMS Final Payment Rules 2022 vs. 2021 Reimbursement for Combination Cataract Canaloplasty Procedures will be more competitive in 2022 Professional fees for Canaloplasty and Canal Implant Combination Cataract were reduced Canaloplasty maintains $350 advantage over Canal Implants in Combination Catara