Sight Sciences, Inc. · NASDAQ:SGHT

Sight Sciences — Investor Presentation (August 2026)

30 slides from Sight Sciences's investor presentation, Aug 5, 2026

  1. Slide 1: Investor Presentation August 2026

    Investor Presentation August 2026

  2. Slide 2: Forward-Looking Statements

    Forward-Looking Statements This presentation, together with other statements and information publicly disseminated by the Company, contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act o

  3. Slide 3: Our Mission

    [[ Our Mission Develop transformative, interventional technologies that allow eyecare providers to procedurally elevate the standards of care — empowering people to keep seeing. | 3

  4. Slide 4: A Glimpse Ahead

    A Glimpse Ahead Innovation leader in two large, growing, underserved markets; Glaucoma and Dry Eye 1 TearCare market access has started with first two MACs establishing fee schedules 2 Strong balance sheet in place to drive commercial growth and long-term investments 3 Strong gross margins and disci

  5. Slide 5: The Intersection of Intervention

    INTERVENTIONAL GLAUCOMA (IG) INTERVENTIONAL DRY EYE (IDE) The Intersection of Intervention

  6. Slide 6: IG + IDE and The Intersection of Intervention

    IG + IDE and The Intersection of Intervention Shared customer base — the same providers can treat both glaucoma and dry eye patients 1 Commercial synergies across IG and IDE teams 2 A common interventional model — procedural intervention vs daily eye drops 3 Large and active installed base. 400K+ IG

  7. Slide 7: A strategic roadmap to transform eyecare for glaucoma and dry eye patients

    A strategic roadmap to transform eyecare for glaucoma and dry eye patients by reducing patient burden, slowing disease progression, and improving outcomes. Embrace procedural intervention as a better alternative to medication management Intervene procedurally and address underlying disease over symp

  8. Slide 8: Interventional Dry Eye

    Interventional Dry Eye A ())

  9. Slide 9: Dry Eye Disease

    Dry Eye Disease - Linked to screen time, age (postmenopausal women, men 50+), systemic medication use - Predominantly managed with daily eye drops (compliance often poor)1 Normal Mild Moderate Severe Large + Underserved Markets $2.4 billion US market for dry eye treatments 2 ~19 million U.S. patient

  10. Slide 10: A new order of care

    A new order of care Effective intervention shouldn’t wait, because meibomian gland dropout is irreversible and critical to ocular surface health1-3 TearCare targets the root cause of MGD: obstructed glands with demonstrated improvement of meibomian gland function4 SAHARA Results: TearCare was clinic

  11. Slide 11: MGD Opportunity

    MGD Opportunity U.S. patients diagnosed with Dry Eye Disease (DED) 1 Million DED patients ~19 Up to 86% of DED is associated with poor tear quality due to Meibomian Gland Dysfunction (MGD )1, 2 Million MGD patients ~13 – 16 ~50% of DED patients have moderate to severe symptoms 1 (most likely to seek

  12. Slide 12: MGD is an Underserved Disease State

    MGD is an Underserved Disease State The current market is dominated by eyedrops that do not address the underlying causes of MGD 1 Many dry eye treatments focus on increasing tear volume in aqueous deficient patients No interventional standard of care for treatment of MGD There is poor patient compl

  13. Slide 13: TearCare Offers a Comprehensive Therapy Intervention

    TearCare Offers a Comprehensive Therapy Intervention Driving Leading Clinical Outcomes for Evaporative Dry Eye Disease Due to MGD OUR TECHNOLOGY: TEARCARE ¹ Estimate based on Dry Eye Treatment Lids shipped as of June 30, 2026. Comprehensive therapy to treat diseased meibomian glands Leading Clinical

  14. Slide 14: TearCare: Designed to Preserve and Improve Gland Functionality

    TearCare: Designed to Preserve and Improve Gland Functionality TearCare is the only FDA-cleared interventional, open-eye, thermal-activated gland expression therapy designed to treat MGD conveniently and comfortably ¹ Gupta et al. Cornea 2022;41:417–426 Thin, wearable SmartLids® conform to the eyeli

  15. Slide 15: SAHARA: Randomized Controlled Trial comparing TearCare and Restasis

    SAHARA: Randomized Controlled Trial comparing TearCare and Restasis®1 - Signs Superiority + Durability 2 - Head-to-Head Study TearCare vs Restasis1 - Large Trial (N=345) - Randomized - Assessor Masked - 3 Stages - Long-term (2-year trial) ¹ Restasis is a trademark of Allergan™ an AbbVie company ² En

  16. Slide 16: SAHARA RCT: Results

    SAHARA RCT: Results ¹ Endpoints for SAHARA include superiority over Restasis at six months in our primary objective endpoint, tear break-up time. TearCare treatment at Baseline and Month 5, Restasis twice a day for six months. Study through 24 months to show duration of effectiveness. ² Restasis is

  17. Slide 17: SAHARA RCT: Results

    SAHARA RCT: Results ¹ 66% of TearCare® patients experienced dry eye relief for 2 years from study baseline. Study baseline refers to assessment at the start of SAHARA prior to any treatment and 5 months prior to the start of the Stage 3 durability stage. Months are measured from Study Baseline. Erro

  18. Slide 18: Scaling Commercially And Pursuing Expanded Market Access

    Interventional Dry Eye ¹ Estimated as of June 30, 2025 based on review of claims data and Company analytics 2 As of June 30, 2026 Scaling Commercially And Pursuing Expanded Market Access With the power of TearCare, we can: Improve the lives of U.S. MGD patients Scale commercial resources with market

  19. Slide 19: Interventional Glaucoma

    Interventional Glaucoma ())

  20. Slide 20: Glaucoma

    Glaucoma - Leading cause of irreversible blindness1 - Predominantly managed with daily eye drops (compliance often poor)2 Normal Mild Moderate Severe Large + Underserved Market ¹ Source: Market Scope 2025 report and JAMA Ophthalmology Prevalence of Glaucoma Among US Adults in 2022 Oct 17, 2024 . ² N

  21. Slide 21: POAG is similar to a clog in a kitchen sink

    POAG is similar to a clog in a kitchen sink: 01 TRABECULAR MESHWORK 02 SCHLEMM‘S CANAL 03 COLLECTOR CHANNELS 01 02 03 The conventional outflow pathway is an important focal point in treating POAG, the most common form of glaucoma The eye’s natural drainage system is called the conventional outflow p

  22. Slide 22: OMNI Surgical System

    OUR TECHNOLOGY: OMNI® SURGICAL SYSTEM OMNI Offers Leading Clinical Outcomes for Primary Open-Angle Glaucoma (POAG) ¹ Estimate based on units of OMNI (and predicates) and SION products shipped as of June 30, 2026 Comprehensive treatment of diseased conventional outflow pathway Leading clinical trial

  23. Slide 23: OMNI Comprehensively Treats the Conventional Outflow Pathway

    OMNI Comprehensively Treats the Conventional Outflow Pathway Minimally Invasive + Efficacious A comprehensive procedure enabled by the OMNI® Surgical System to help restore natural outflow in the eye with up to 360° treatment of all three areas of resistance* in the conventional outflow pathway * Tr

  24. Slide 24: OMNI is Proven with Robust Clinical Evidence & Broad FDA Indication

    OMNI is Proven with Robust Clinical Evidence & Broad FDA Indication AGIS-7 Findings3 <18 mmHg is the target IOP to limit the progression of glaucoma. On average, there was zero change in visual field defect score for patients whose IOP stayed below 18 mmHg over 6 years. OMNI is the most comprehensiv

  25. Slide 25: Consistent Efficacy of OMNI in Combination Cataract and Standalone Trials

    Consistent Efficacy of OMNI in Combination Cataract (CC) and Standalone (SA) Clinical Trials COMBINATION CATARACT STANDALONE EFFICACY DEMONSTRATED OUT TO 3 YEARS GEMINI (12 Months)* ROMEO Elevated IOP CC (24 Months) ROMEO Elevated IOP SA (24 Months) TREY SA (11 Months)* GEMINI 2 IOP Outcomes CC (36

  26. Slide 26: OMNI Addresses All Six MIGS POAG Categories

    OMNI Addresses All Six MIGS POAG Categories and Allows Surgeons to Customize Treatment ¹ Represents Company analysis of third-party estimates based on 2025 data MILD DISEASE (40%) MODERATE DISEASE (40%) ADVANCED DISEASE (20%) ~$2B opportunity ~$2B opportunity ~$1B opportunity ~$0.4B opportunity ~$0.

  27. Slide 27: Large and Unmet Clinical Need for Standalone MIGS

    Large and Unmet Clinical Need for Standalone MIGS Combination Cataract Standalone | 27 ~15% of POAG eyes1, ~90% of MIGS procedures1 Established, growing market Benefits from inherent IOP-lowering effect of cataract surgery Share-taking driven by efficacy, fast recovery times and attractive safety pr

  28. Slide 28: MIGS for the Standalone Pseudophakic Patient

    MIGS for the Standalone Pseudophakic Patient The Glaucoma Patient Journey1 1 ESCRS. “Glaucoma Treatment Paradigm Shift.” By Dr. Karl Mercieca. EuroTimes. 2 Selective Laser Trabeculoplasty . Zone of unmet clinical need Pseudophakic POAG Patients 3-7 yrs post-op Glaucoma Diagnosis Patient diagnosed wi

  29. Slide 29: Financial Performance

    Financial Performance SGHT DRY EYE GLAUCOMA Y/Y % Growth +20% Q2 2026 Y/Y Revenue Growth FY26 Guidance Revenue $88M - $92M¹ Adj. OpEx² 92M - $94M¹ Historical financial results, including with respect to revenue and gross margin, may not be indicative of future financial results due to numerous risks

  30. Slide 30: Keep Seeing

    Keep Seeing TM

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