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Slide 2: USCOM is an Australian listed medical device company
USCOM LTD | USCOM...... *is an Australian listed medical device company * Developed and marketing a device for monitoring cardiac blood flow * Sydney based with an office in Coffs Harbour and representatives based in Melbourne, Brisbane and LA * 17 employees * $384,390 in product revenue for FY’04
Slide 3: The USCOM 1A Cardiac Monitor
-USCOM LTD ity Pr The USCOM 1A Cardiac Monitor * Sophisticated ultrasound ¢ Simple to use ¢ Safe and accurate ¢ Increased information « Hand operated by medical, nurse or paramedics * Cost-efficient; Decreased cost, increased reliability
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Slide 6: Survey of physicians and nurses worldwide
Survey of 700 physicians & nursés worldwide, conducted by General Electric Medie @ GE Medical Systems USCOM ... meets that need!
Slide 7: Cardiac output is the gold standard measurement of human health
- Cardiac output is the gold standard m asurem nt oPhum i health. - Current methods of cardiac monitoring are exp fe, invasive, technically difficult or with variable accuracy. ed - Huge demand for a safe, more accurate and efficient solution.
Slide 8: Clinical applications
USCOM LTD. @ Anaesthetics @ Paediatrics @ Emergency Care @ Intensive care @ Renal medicine @ Transplantation and pacemaker @ Sleep medicine @ General Practice @ Nursing homes @ Home monitoring @ Sports Medicine
Slide 9: Applications and US collaborations
| _§ — suscom itp Applications u.s. coLLABoRATIONS EMERGENCY CARE PAEDIATRICS ANAESTHETICS & CARDIOLOGY
Slide 10: Henry Ford Hospital, Detroit
Henry Ford Hospital, Detroit, Michigan Dr Emanuel Rivers
Slide 11: US collaborations: Emergency care
USCOMLTD | / \pplications uss. COLLABORATIONS EMERGENCY CARE University Of Pittsburgh Medical Centre Loma Linda University Hospital, California Beth Israel Medical Centre (Columbia School of Medicine), Boston
Slide 12: US collaborations
USCOM LTD. LABORATIONS cain Li a cMarens ae Vanderbilt Children’s Hospital Children’s Medical Centre Nashville Dallas, Texas
Slide 13: University of Arizona Medical Centre
University of Arizona Medical Centre Dr Peter Lichtenthal Tucson, Arizona & Dr Jack Copeland
Slide 14: Validation approach
1. Laboratory based precision testing 2. Tested against Flow Probes in animals 3. Tested against Catheters -— the “gold standard”
Slide 15: Validation stage 1: lab based testing
Cia | e : __USCOM LTO ” Validation: stace 1- LAB BASED TESTING com MECABIO Institute, France Computer controlled haemodynamics model Exact agreement from —1.0 to 1.6 metres per second
Slide 16: Validation against flow probes
POW Hospital, Hong Kong Flow probes in dogs. Mean difference: 1.1% (n=335) Study presented at World Congress of Anaesthesiology Paris, May 2004 Florey Institute, Melbourne Flow probes in sheep Mean difference: Less than 1% (n=16)
Slide 17: Validation against catheters: hospitals
Royal Perth Hospital Hannover Uni. Hospital Uni. of Arizona Medical Centre Sir Charles Gairdner, Perth
Slide 18: Comparison of cardiac monitoring methods
-USCOM LTD | Reliable + reproducible Noninvasive Inexpensive USCOM (Doppler) VVo VVo VVVo Plethysmography v VVv Vv TOE Doppler Vv Vv NICO (Mod Fick) Vv LidCo (LiCl dil) ‘a4 PICCO (Mod Tx) Vv VVo Thermodilution (Tx) Vv
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Slide 20: Catheter cost and survival
-USCOM LTD. US$132,000 2 OQ Without Catheter US$78,000 With Catheter Proportion Surviving ° ) 5 10 15 20 25 30 With Without Follow-up Time (Days) Catheter Catheter
Slide 21: USCOM LTD
USCOM LTD
Slide 22: Theoretical model for market scale
Theoretical model for market scale ° US = 5,800 hospitals * * Assume 4% penetration over 3 years = 232 sites ¢ Assume an average 3 units per site = 696 units * Sale price of US$20,000 (after sales commission) - Gross revenue = US$13,920,000 * Gross revenue = A$17,846,000 ¢ US = 33% of world market (
Slide 23: Adoption curve
USCOMLTD | Adoption Bell Shaped Adoption Curve 25 9 Ln 20 9 ? ? i 9 Clinician adoption —*—Patient expectation 109 54 [sre 13 14 A A. Time A J Early adopters Norms Laggards
Slide 24: Patent description and application
Patent Description Application USCOM Intracardiac CW Doppler Core Patent Core Patent: The use of CW Ultrasound, transcutaneously (through the skin), for the monitorng of cardiac flow. Registered: June 1998. Published US Patents Office: May 2003
Slide 25: Management team
USCOM LTD ce Ty ! a ie \ Paul er (Chairmars} (General Manager & Operations} Business Science Operations
Slide 26: Advisory Board
visory Board: Me Rob Phillips FR. O.MU. AMS Dr Fred Berry MBBS, FANZCA Professor Stephane Carlier Mp, Ph.D. Professor Colin Sullivan MD PhD FRACP Dr Greg Clark Pp. Professor Malcoim West MBBS, Pht, FRACP Professor C.F, Lau MBBS, MD Dr Karsten Knobloch vp Chairman of USCOM Leading Anaasthetist Cardio
Slide 27: UCM share price chart
ConmSec @ PARHECH Charts UCM.--USCOM LIMITED 18-Jan emeenonmancanae : ory nn ad ~ a 3a 3.6.05 : & --Escrow release: {73.4 3 s oS e = = =) ty o Po 2 <3 Sector _ weakening 5 F 7 2 “<6GT driven" E rofit takin ° ctl : faye ' : : ae ' ba a E Jan. Feber. Ayr. Mary Jun Jul ALI) Sep Oct Mov. Dec Jan 3 o4 a4
Slide 28: The Listing: top shareholders
The Listing Top 15 elt a wong Rob Phillips 16,590,000 43.7% Gary Davey 6,000,000 15.8% Guardian Trust (Bell) 3,300,000 8.7% Luke Fay 737,500 1.9% Link Traders 500,000 1.3% Jules Flach 500,000 1.3% Catholic Church Ins. 400,000 1.1% Das Menean 368,750 4.0% Matthew Hollier 366,750 1.0% Helen Bragg 368,
Slide 29: Milestones
USCOM LTD _ * 20 new validation studies presented * Regulatory approval for Europe, China, Japan & US * Establish global distribution structure * Build quality engineering & marketing teams - First Hospital Sales in Aust, Asia & Europe. 50 sold to date * Prepare for US market entry in calendar 2005
Slide 30: Growth Strategy
Se *” Growth Strategy: * FDA approval and US sales by mid 2005 * Focus on hospital market ~ cu, ER, Paediatrics & Anaesthetics * Development of Asian & European markets * Global network of marketing partners — mostly variable cost * Medical rebate plan — expand into GP & clinic market * Continue evo
Slide 31: Challenges
Challenges * it takes time to change medical practice * Capital budgets tight and buy cycles long * Australian hospitals especially slow to adopt new tech © * US Market entry will be challenging * No guarantee our patents won’t be attacked in the future
Slide 32: USCOM is...
_ USCOMLTD _ USCOM is...... * A unique product with a global market * Adequately resourced for identifiable needs * Highly focused on products, target customers & markets * Low fixed costs * Meeting its milestones * Building a quality team for the long term
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