Slide 1: Evogene Quarterly Update: Validation Results & Updates August 2016
Validation Results and Update August 2016 Evogene Update Validation Results & Updates August 2016 Evogene Quarterly Update Validation Results & Updates August 2016
Slide 2: Safe Harbor Statement
Safe Harbor Statement * This presentation contains "forward-looking statements" relating to future events, and we may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting Evogene Ltd. or i
Slide 3: Introducing Evogene
Introducing Evogene * Located HQ - Rehovot, IsraelR&D site - St. Louis, USA~200 employees, 80% R&DListed - TASE (2007); NYSE (2013)Innovative discovery technology - broadly applicable proprietary platform, combining cutting-edge computational capabilities with interdisciplinary biological expertise
Slide 4: Improved seed traits
Improved seed traits Rescene sue discovery to, ot hn, %, Seed Traits ‘Ag-Chemicals Ji Ag-Biologicals om - BPs
Slide 5: Improved seed traits: Market overview & potential
5 WW Seed Market, $B * * * * 40.6 Significant market* Yield $1.5B $1.2B Drought tolerance $0.65B $0.45B Insect resistance $3.2B $0.5B Disease resistance $1B $1B Herbicide tolerance $3.5B $1.5B Corn Soy Trait potential – per crop** * Conventional seeds Biotechnology seeds Biotechnology seedprice to f
Slide 6: Improved seed traits: Yield & abiotic stress tolerance
* Subset of genes improved predicted trait attributes for yield - Further testing undertaken for these genes as well as additional previously discovered genes Plant genes demonstrated potential to achieve yield enhancement in corn and soybean Improved seed traitsYield & abiotic stress tolerance - re
Slide 7: Improved seed traits: Insect Control
* Microbial genes demonstrated activity against target insects Examples for positive microbial genes – demonstrated positive results in insect feeding assay Improved seed traitsInsect Control – recent results & updates
Slide 8: Improved seed traits: Nematode & disease resistance
* Example for active gene – activity in soybean model system Plant genes reducing nematode infection by up to 70% Plant genes conferring resistance to disease in Banana Example for active gene – activity in Banana against Black Sigatoka disease Eight events were evaluated, statistically significantM
Slide 9: Improved seed traits: Promoters
* Improved seed traitsPromoters– recent results & updates Promoters* with initial validation for specific expression patterns Examples for successful promoter predictions – initial positive results in model plant validation *Segments of DNA that determine expression patterns for genes. Such promoter
Slide 10: Innovative Ag-Chemicals
Innovative Ag-Chemicals Revosene sue discovery to, ot hn, %, ‘Ag-Chemicals JM Ag-Biologicals 2s
Slide 11: Innovative Ag-Chemicals: Market overview & potential
* Huge market - ~$55B* in 2014 Need for herbicide innovation ($14.85B) ($14.3B) ($1.65B) Herbicides Insecticides Fungicides Others * Source: Phillips McDougall , 2014 Herbicides - combat invasive weeds Rising weed resistance for existing herbicides Growing need for innovation Increasing regulation p
Slide 12: Innovative Ag-Chemicals: Herbicides
* Example for Herbicide Target - induced inhibition of targets leads to plant death Herbicide Targets validated in plant system Compounds displaying herbicide activity against weeds Example for Compound - displaying herbicidal activity In greenhouse Target inhibition - dying plant Normal target acti
Slide 13: Novel Ag-Biologicals
Novel Ag-Biologicals Rosen “ane discovery to, in, £ % levogene Crop Protection Seed Traits Ag-Chemicals || Ag-Biologicals | Pe. |S
Slide 14: Novel Ag-Biologicals: Market overview & potential
* Major ag companies taking significant steps to enter this market Harnessing the power of Microbiome acquired joint venture acquired acquired acquired Data based on Research and Markets, 2016 Growing market* E Novel Ag-BiologicalsMarket overview & potential * Human microbiome understanding leverage
Slide 15: Novel Ag-Biologicals: Biostimulants
* Microbials impacting model & target crops Example for microbial ‘hit’- positive results in greenhouse screens Model plant - Brachypodium yield assay:Improved vegetative & yield responses & earlier heading Target crop - Corn vegetative assay* : Improved vegetative responses No treatment No treatmen
Slide 16: Thank you
N evogene Plant Innovation Mn > 9 A Thank you.