Pressure BioSciences, Inc. · OTC:PBIO
Pressure BioSciences — Investor Presentation (December 2013)
28 slides from Pressure BioSciences's investor presentation, Dec 12, 2013
Slide 1: Investor Presentation - Pressure BioSciences, Inc.
Investor Presentation Pressure BioSciences, Inc. (OTCQB: PBIO) Discovery Starts with Sample Preparation™ Richard T. Schumacher President & CEO Jeffrey N. Peterson – Board Chairman Vito Mangiardi, MBA Kevin A. Pollack, Esq., MBA Mickey Urdea, Ph.D. December 12, 2013
Slide 2: Forward Looking Statements
Forward Looking Statements This presentation may contain forward looking statements that reflect management’s current views and opinions as to the status of the Company’s products, technology and other future events and operations. These statements are neither a promise nor guarantee, but involve ri
Slide 3: Experienced Senior Management & Board
Experienced Senior Management & Board Management • Mr. Richard T. Schumacher, President & CEO Boston Biomedica (CEO, Founder); Panacos Pharma (President, Co-founder); Trinity Biotech (Founding Group); CBR Labs (Gen’l Mgr) - Harvard Medical School • Dr. Edmund Y. Ting, Senior Vice President of Engine
Slide 4: Company Overview
Company Overview • OTCQB: PBIO • Ten (10) Full-time Employees • Strong Management Team and Board of Directors • 24 Patents: Pressure Cycling Technology (PCT) Platform • Early Revenue: 2011 ($988K), 2012 ($1.2M), Q1–Q3 2013 ($1.15K) • 12.0M Common Shares & 8.0M Preferred Shares OS • Market Cap (fully
Slide 5: What is a Biomarker?
What is a Biomarker? Molecules (e.g., genes, proteins, lipids) found in tissue (e.g., cells) or body fluids (e.g., blood) that correlate – directly of indirectly – with the presence or absence, the progression or recurrence, and the effects of treatment on a disease or a disorder. PSA LDL Cholestero
Slide 6: Estimated Market: Biomarker Discovery
Estimated Market: Biomarker Discovery WW Biomarker Market Est. to Reach $25.79B by 2016 - 2012 ASDReports 6
Slide 7: Pressure Cycling Technology
Pressure Release Cycling Important Technology Biomolecules (PCT) by Cell Lysis 7
Slide 8: Sample Input Quality = Sample Result Quality
Sample Input Quality = Sample Result Quality Scientific research can be broken down to three key elements: sample preparation, analysis, & data reduction/interpretation “Discovery Starts with Sample Preparation” 8
Slide 9: Competitive Landscape
Competitive Landscape Mostly Commodity Products Through Catalogue Sales • Mortar & Pestle • Dounce homogenizer (glass on glass) • Potter-Elvenhjem homogenizer (Teflon on glass) • Enzymatic Digestion • Polytron shearing homogenizers • Blenders • Bead Beating • Sonication • Repeated Freeze/Thaw cycles
Slide 10: PCT Sample Preparation System
PCT Sample Preparation System Barocycler™ NEP2320 Barocycler™ NEP3229 PULSE Tube MicroTubes PCT-dependent Kits 10
Slide 11: Next Gen PCT Platform: HUB Family of Barocyclers
Next Gen PCT Platform: HUB Family of Barocyclers High Pressure Generators for Multiple Research & Mfg Applications • Compact • Portable • Versatile • Computer Controlled • Labview Software Driven • Pressures to: • 20 kpsi (HUB160) 2012 • 60 kpsi (HUB440) 2012 • 100 kpsi (HUB880) 2014 …the HUB for ev
Slide 12: The Shredder SG3
The Shredder SG3 The Shredder SG3 Low Shear, Mechanical, Homogenization Device Long lasting lithium rechargeable batteries Paddle for convenient pressure setting Pressure force levels: 15, 30, 45 lbs. Force Uses PCT PULSE and Shredder Tubes Heavy Duty, Robust Driver 12
Slide 13: Selected Marquee Customers (40 of 150)
Selected Marquee Customers (40 of 150) • Amgen • Thermo Fisher • Biogen • Target Discovery • Lilly • Battelle Memorial Institute • Novartis • Harvard Medical School • Monsanto • Harvard School of Public Health • BM Squibb • Rockefeller University • Merck • University of New Hampshire • Centocor • Ba
Slide 14: Professor Wayne Hubbell - UCLA
Professor Wayne Hubbell - UCLA Distinguished Professor of Chemistry & Biochemistry, and Jules Stein Professor at UCLA "Protein flexibility is the new frontier in understanding protein function and regulation. The study of proteins under pressure has great ability to reveal salient features of protei
Slide 15: Dr. Henry C. Lee
Dr. Henry C. Lee Professor of Forensic Science and founder of the Forensic Science Program at the University of New Haven; founder of the HC Lee Institute of Forensic Sciences; and former Commissioner of Public Safety for the State of Connecticut. “We are excited about this opportunity to collaborat
Slide 16: PCT Focus Area: Biomarker Discovery
PCT Focus Area: Biomarker Discovery Cancer, Heart Disease, Inf. Diseases, Neurological Disorders, Forensics, Etc. Dr. Andreas Huhmer – Thermo Fisher Scientific …advantages of speed and quality using PCT in mass spec workflow Dr. Michael Alterman – Tumor Vaccines and Biotechnology Branch, CBER, FDA …
Slide 17: Value Proposition: PCT & Biomarker Discovery
Value Proposition: PCT & Biomarker Discovery • Analysis of DNA, RNA, Proteins, & Lipids (“biomolecules”) is Crucial to the Discovery of New Biomarkers • The Quality of Results of Biomolecule Analyses Depends Significantly on the Quality of the Preparation of the Sample • Current Sample Preparation M
Slide 18: 2014 Potential Driver: Barocycler HUB880
2014 Potential Driver: Barocycler HUB880 First Delivery Unit • 7000 Bar (100,000 psi) max pressure- same as in M1 tank 120mm gun chamber ! • Newest addition to HUB family of pressure generators • Targeted at HP protein, bacteria, spore, and virus research • Also basic material (polymer, fluids) comp
Slide 19: Manual to High Throughput PCT
June 2013 Technology Breakthrough Manual to High Throughput PCT From Dream to Reality Manual Processing of Automated Processing of Multiple (24-96) Individual (1-48) Sample Tubes Sample Tubes (wells) Simultaneously 1 9
Slide 20: High Throughput Screening of Samples
High Throughput Screening of Samples Automated liquid handling helps ensure accuracy and reproducibility, eliminates repetitive tasks, and frees personnel for other activities. LEAP Technologies 2 0
Slide 21: 2H 2014 Potential Driver: High Throughput PCT
2H 2014 Potential Driver: High Throughput PCT Holder for Standard “PCR” sample (9mm) plate design (up to 6 strips of 8 wells) • Initial Application: – High pressure accelerated digestion • Consumable: – Proprietary PBI 8 well strips • Max Number of Samples: – 48 (2X3X8) samples • User Control: – Tou
Slide 22: PressureFlex Micro-wells
PressureFlex™ Micro-wells Fill the 2 Up to 3 1 strips can be sample wells and place a loaded on a silicone cap support over plate. mPFwell. Samples are Install 4 now in 3 retention support plate spring clip and ready to over tubes be loaded and support into the plate. carrier. 2 2
Slide 23: Barozyme Sample Carrier
Barozyme Sample Carrier Open Insert 1 empty 2 support plate carrier. with samples into carrier. Carrier with Latch cover 4 up to 48 3 and close. sample wells Side 1 Load side 2 now ready to with an be placed additional 3 into the strips of pressure samples if OK to chamber. Side 2 needed. go! 2 3
Slide 24: PBI Barozyme Sample Carrier
PBI Barozyme™ Sample Carrier PressureFlex™ strips are the only “PCR” type strip that allow hydrostatic pressure to be easily transmitted into the sample. The samples remain leak free even under repeated 20,000 psi hydrostatic pressure cycles. Up to 6 PressureFlex™ mwell strips are nested for a total
Slide 25: PCT-based, High Throughput, Barozyme
2H 2014 Potential Driver: High Throughput PCT PCT-based, High Throughput, “Barozyme” instrument 2 5
Slide 26: High Throughput Screening of Samples
High Throughput Screening of Samples Automated liquid handling helps ensure accuracy and reproducibility, eliminates repetitive tasks, and frees personnel for other activities. LEAP Technologies 2 6
Slide 27: Significant Achievements: 2013
Significant Achievements: 2013 • Nov 7th: Reported Record Quarterly (Q3) and YTD Total Product Revenue, Including Record Quarterly (Q3) and YTD Consumables Sales • Aug 1st: UCLA Scientists Presented Data on an Advanced Pressure-based Instrument System for Biomarker Discovery • June 14th: Announced F
Slide 28: Key Investment Highlights
Key Investment Highlights • Pressure Cycling Technology (PCT): Powerful, Enabling, Patented • PCT Represents the Next Generation Platform for Biomarker Discovery • PCT Products Offer Significant Advantages Over Competitive Methods • Proven Technology: ~ 250 Installations in ~150 Marquee Laboratories
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