Pressure BioSciences, Inc. · OTC:PBIO
Pressure BioSciences — Investor Presentation (May 2023)
25 slides from Pressure BioSciences's investor presentation, May 2023
Slide 1: Commercializing the Gentle Giant of Thermodynamics
Pressure BioSciences Commercializing the Gentle Giant of Thermodynamics Focus: Ultra Shear Technology™ (UltraShear™) (OTCQB: PBIO) Investor Presentation May 2023 Richard T. Schumacher President and CEO Commercialization Initiated UltraShear Platform for Nanoemulsion Production
Slide 2: Forward Looking Statements
FORWARD LOOKING STATEMENTS This presentation may contain forward looking statements that reflect management’s current views and opinions as to the status of the Company’s products, technology and other future events and operations. These statements are neither a promise nor guarantee but involve ris
Slide 3: Company Management
Company Management (OTCQB: PBIO) Mr. Richard T. Schumacher: Founder, President, and CEO Boston Biomedica, Inc. (NASDAQ: BBII): CEO, Founder; Panacos Pharma (NASDAQ: PANC): President, Co-founder; Trinity Biotech (NASDAQ: TRIB): Founding Group; Harvard Medical School (CBR Labs – GM, Scientist); UNH (B
Slide 4: Ultra Shear Technology: Different Levels of Pressure
Ultra Shear Technology (UST) Different Levels of Pressure… TM PCT Barocycler 2320EXT Marianas Trench Combines UHP (45,000 – 60,000 psi) Vice with Intense Shear Forces. 45,000 psi High Quality Nanoemulsions Over 350 — Barocycler Systems Installed Worldwide Car Tire 16,500 psi 500 psi 30 psi Too Much
Slide 5: Three Enabling High Pressure Platforms
Pressure BioSciences, Inc. (OTCQB: PBIO) Three Enabling High Pressure Platforms (30 total patents) Driving Discovery & Quality Improvement in Critical Research & Manufacturing Areas of the Life Sciences, Food & Beverage, Cosmetics, Nutraceuticals, Agrochem, and Other Industries Pressure Cycling Tech
Slide 6: Over 225 Customers (350+ PCT Systems) Worldwide
Over 225 Customers (350+ PCT Systems) Worldwide Industry, Academia, Government Clients & Key Opinion Leaders BioPharma Agriculture Research Nutraceuticals Industruial Manufacturing Cosmetics This communication does not constitute an offer to buy or sell or the solicitation of an offer to buy or sell
Slide 7: Emulsions: Mixtures of Immiscible Liquids
Emulsions: Mixtures of two or more liquids that are immiscible in each other (e.g., oil & water) • Thousands of products used everyday are oil & water emulsions /have oil-based actives • Pharmaceuticals (e.g., majority of all new drug candidates are hydrophobic) • Health & Wellness Products (e.g., v
Slide 8: Nanoemulsions
Nanoemulsions • Widely recognized to exhibit significant improvements over Macro/Microemulsions • High Water Solubility • Exceptional Bioavailability (rapid & complete absorption) • Excellent Long-term Stability UST • Translucent BaroFol • Current processing methods/equipment for NE production (non-
Slide 9: Ultra Shear Technology Platform
Ultra Shear Technology™ (UST™) Platform: Revolution in Nanoemulsion Processing – Better, Cheaper, Faster, & Smarter • UST uniquely combines ultra-high pressures with intense shear at controlled temperatures • UST produces highly-stable, water-soluble, oil-in-water Nanoemulsions • Selectable (“Dial I
Slide 10: Broad Market Potential
Broad Market Potential Shifting Our Focus (and Scale) from R&D to MANUFACTURING • Pharmaceuticals / Vaccines (bioavailability, adjuvants, liposomes) • Cosmetics / Skin care • Eco-friendly Agrochemicals (essential oils) • Health & Wellness Products • Nanotechnology / Advanced materials • Lubricants /
Slide 11: Applications in Pharmaceuticals: Prednisone Nanoemulsions
Applications in Pharmaceuticals: Prednisone Nanoemulsions A. Oil droplet size B. Clarity C. Stability (A) Mean oil droplet size (nm) of prednisone AO and GSO nanoemulsions as a function of the number of UST cycles at 45,000 psi. (B) Optical clarity of prednisone AO and GSO formulations. (C) Stabilit
Slide 12: Applications in Cosmeceuticals: Retinol Nanoemulsions
Applications in Cosmeceuticals: Retinol Nanoemulsions A. Oil droplet size B. Clarity C. Stability 54 nm (A) Progressive reduction of mean hydrodynamic diameter (Dh) of oil droplets as a function of the number of UST cycles reaching a minimum particle size of 54 nm. (B) Increasing clarification was c
Slide 13: Applications in Agrochemicals: Neem Oil Nanoemulsions
Applications in Agrochemicals: Neem Oil Nanoemulsions (A) 100% neem oil congealed at room temperature. (B) Progressive decrease in hydrodynamic diameter (Dh) of oil droplets produced over 1-14 UST cycles (red) corresponding to decreased light scattering and increased clarity (blue dashed line). (C)
Slide 14: Astaxanthin Nanoemulsions Prepared by UST
pre- Astaxanthin Nanoemulsions Prepared by UST UST Rapid size reduction and clarification UST Single pass 300 MPa 50 µm This communication does not constitute an offer to buy or sell or the solicitation of an offer to buy or sell any securities. 14
Slide 15: Applications in Nutraceuticals: Curcumin nanoemulsions
Applications in Nutraceuticals: Curcumin nanoemulsions * Oil droplet size <40 nm ¢ High optical clarity * — Stability over seven freeze-thaw cycles 240 90 180 e ~ Py 60 E 8 = 120 r 8 4 nN 30 60 37nm *S 0 0 0 2 4 6 8 10 12 0 2 4 6 UST cycles 8 10 oil droplet size (nm) 0 f=) a fo} b o N is} 0 o 12 3 4
Slide 16: CBD Nanoemulsions in Camelina Oil Formulations
CBD Nanoemulsions in Camelina Oil Formulations Figure 1. Characterization of CBD nanoemulsions formed using camelina oil (CO), hempseed oil (HSO), and golden hemp seed oil (GHSO). (A) Mean hydrodynamic diameter (Dh) of oil droplets measured by DLS. Camelina oil (red) produced the smallest oil drople
Slide 17: UST CBD Nanoemulsions
UST CBD Nanoemulsions A revolution in blending oil and water Conventional UST Process Conventional Emulsion UST Nanoemulsion Process CBD Oil CBD Oil Day 0 10% oil in deionized water Identical formulation 6 UST passes @ 40,000 psi 9% Polysorbate 80 (emulsifier) 20 passes @ 40 kpsi RESULT: Transparent
Slide 18: UST Process allows to dial in desired droplet size and clarity
UST Process allows to “dial in” desired droplet size and clarity. 160 100 140 80 120 Pre-UST 100 60 1 2 3 4 5 6 80 60 40 135 120 86 56 47 46 40 nm nm nm nm nm nm 20 20 0 0 0 1 2 3 4 5 6 7 Droplet Diameter (nm) Transmittance (%) 18
Slide 19: Oil & Water DO Mix – with UST Processing!
Oil & Water DO Mix – with UST Processing! “Water Soluble?!?” CBD* Formula “-” UST Commercially Obtained UST- Processed CBD* “+” UST Formula: PBI *same amount of CBD
Slide 20: UST Platform: Unique, Patented, Commercially Available
UST Platform: Unique, Patented, Revolutionary & Commercially Available (Q4 2022) During 2022, we have successfully nanoemulsified the following oil-based active ingredients. ● CBD ● THC ● Astaxanthin ● Curcumin ● Algae Oil ● Neem Oil ● Prednisone ● Vitamin C (lipid soluble) ● Retinol (Vit. A-1) ● Re
Slide 21: Pivotal Change in Business Strategy (2023)
Pivotal Change in Business Strategy (2023): UltraShear 90% of PBIO’s Effort • Toll Processing Center for UltraShear Nano CBD/nutraceuticals/cosmeceuticals bulk • Partners to vial, label, sell, and distribute final material from PBIO’s bulk – their product • First nano-CBD product: 100% plant-based r
Slide 22: Long-Term Collaboration Between PBI & Dr. Denese Skin Science
Long-Term Collaboration Between PBI & Dr. Denese Skin Science December 4, 2022 Personal Correspondence “I have NEVER encountered such a profound tightening and wrinkle reducing effect as I found with the PBI nanoemulsified Retinoate serum…even compared to my best, already effective serums, the PBI p
Slide 23: Long-Term Collaboration Between PBI & Dr. Denese Skin Science
Long-Term Collaboration Between PBI & Dr. Denese Skin Science October 26, 2022 PBI Press Release "The most-requested addition to our product line is an effective intervention for age-related hair loss in men and especially in women. I believe that UltraShear will enable us to introduce our first-eve
Slide 24: UST News - 2023
UST News - 2023 April 26 PBIO Updates Rapid Progress on Limited Offering of Exclusive THC Licenses April 21 PBIO Unveils Powerful THC Market Exclusive Licensing Opportunity April 14 (i) Add’l THC Marketing Study; (ii) Academic Publication Due Soon - “Best-in-Class” April 18 Expansion into Strategic
Slide 25: Thank You!
Pressure Cycling Technology PCT Biomarker Discovery and Diagnostics Products Baro BaroFold Technology Thank You! Bioprocess Development Products & Services Fold Ultra Shear Technology UST Nanoemulsion Technology | Equipment and Formulation Services PBI has announced its intention to up-list in 2023.
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