Slide 1: On a mission to enhance the diagnosis of 100 million hearts
On a mission to enhance the diagnosis of 100 million hearts Redeye Artificial Intelligence Seminar 2022 Helen Ljungdahl Round CEO Samuel Schmidt R&D March 16, 2022
Slide 2: We all deserve to know immediately if our chest pain is related to heart disease
We all deserve to know immediately if our chest pain is related to heart disease or not Potential impact: • Patients • Doctors • Health Care Systems
Slide 3: Acarix Leading the Paradigm Shift
Acarix Leading the Paradigm Shift AI-powered assessment of Coronary Artery Disease (CAD) Only 1 out of 10 with stable chest pain have CAD Rule-out of CAD in 10 min with > 96% confidence The CADScor® System enables non-invasive rule-out of patients More than 8,000 patients in clinical trials With uni
Slide 4: Demonstrating Clinical Value in Less than 10 Minutes with CAD Rule-out
Demonstrating Clinical Value in Less than 10 Minutes with CAD Rule-out Intended use (FDA) 1 The intended use of CADScor®System is to record CADScor® heart sounds, i.e., murmurs and vibration for Rule-out calculation of a patient specific score, the CAD- score, indicating the risk of coronary stenosi
Slide 5: The SCIENCE behind CADScor System and the CAD-score
The SCIENCE behind CADScor®System and the CAD-score
Slide 6: The Idea Behind the CAD-Score
The Idea Behind the CAD-Score Coronary artery disease (CAD) causes week alterations in the heart sounds • Narrowing’s caused by plaque build up will produce turbulent blood flow, which makes a weak noise • The relaxation of the heart is altered by CAD, which changes the heart sounds These sound are
Slide 7: The NOVEL CADScor System
The NOVEL CADScor®System Ultra sensitive and intelligent AI-powered diagnostic aid, rooted in strong Danish audio industry and academia Embed Algorithm Touch sensitive screen Microphone for ambient noise cancelling Sensitive microphone Heart sound recording CAD-score ≤20 CAD-score >20 Low risk of CA
Slide 8: AI Algorithm for Acoustic Detection of CAD
AI Algorithm for Acoustic Detection of CAD 0.1 0.05 0 -0.05 -0.1 20 20.5 21 21.5 22 22.5 23 23.5 24 24.5 25 Time (s) Segment the heart sound recording into Noise reduction Feature extraction Classification heart beats 0.3 0.2 CAD-score >20 0.1 SysFRP Elevated risk of CAD FRP 0 HRV -0.1 PCAR Acoustic
Slide 9: The need for Rapid Rule-out
The need for Rapid Rule-out Low diagnostic yield of current diagnostic methods Current noninvasive testing includes: • Cardiac CT • Stress ECG • SPECT 90-94% patients undergoing Current noninvasive testing is noninvasive testing • Costly do not suffer • Depends on specialized from CAD 1,2 equipment
Slide 10: Rule-out Capacity of CADScor System
Rule-out Capacity of CADScor®System The point-of-care CADScor®System can safely rule out more than one third of patients referred for non-invasive testing with at least 96% certainty 2/3 Non-invasive testing 1/3 No further assessment for CAD Schmidt, S. E., et al. "Coronary artery disease risk recla
Slide 11: A Clinical Powerhouse and Continued Clinical Development
A Clinical Powerhouse and Continued Clinical Development Patients included: • Reported studies: 2,790 • Ongoing studies: ~3,800 Clinical trials used for development and validation of Algorithm Clinical trials used for external validation ADOPT CAD BIO-CAC DAN-NICAD DAN-NICAD II VALIDATE (2018-20) (2
Slide 12: Why engage and invest in Acarix?
Why engage and invest in Acarix? 1. Solid R&D and patented technology, published clinical data and regulatory approvals Strong platform foundation with patented technology. Clinical data completed and published. Now ready to scale and drive impact for Acarix, health care providers and patients 2. St
Slide 13: Thank you!
Thank you! acarix?