Novocure Limited · NASDAQ:NVCR
Novocure — Investor Presentation (October 2024)
23 slides from Novocure's investor presentation, October 2024
Slide 1: Novocure October 2024
novecure’ Novocure October 2024 patientforward”
Slide 2: Forward-looking statements
novocure forward-looking statements In addition to historical facts or statements of current condition, this presentation may contain forward-looking statements. Forward-looking statements provide Novocure's current expectations or forecasts of future events. These may include statements regarding a
Slide 3: 2023 achievements and 2024 milestones ahead
2025 achievements and 2024 milestones ahead DRIVING COMMERCIAL ADVANCING ADOPTION CLINICAL TRIALS 2023 France reimbursement LUNAR data presented New array launched ACHIEVEMENTS — achieved and launch LUNAR USS. FDA PMA, CE Mark in Europe and Japanese PMDA submitted New array FDA PMA METIS enrollment
Slide 4: Together with our patients, we strive to extend survival
together with our patients, we Strive to extend survival in some of the most aggressive forms of cancer patientforward’ o224Novoctre GnbH. 4
Slide 5: Tumor Treating Fields are selectively tuned electric fields that kill cancer cells
novocure’ Tumor Treating Fields (TTFields) are selectively tuned electric fields that exert physical forces to kill cancer cells TUNED ELECTRIC FIELDS DISRUPT PROTEINS DURING CELL DIVISION CAUSING CANCER CELL DEATH TTFields 100 to 500 kHz tumor cell healthy cell patientforward® © 2024 Novocure GmbH
Slide 6: Optune Gio wearable cancer therapy system
novecure’ Optune Gio® wearable cancer therapy system DELIVERS CONTINUOUS TUMOR TREATING FIELDS THERAPY TO SOLID TUMORS TWO PRIMARY COMPONENTS electric field generator and transducer arrays “a patientforward” Optune Gio® is intended as a treatment for adult patients (22 years of age or older) with hi
Slide 7: Strategy for long-term growth
novecure’ Strategy for long-term growth drive commercial advance deliver adoption clinical trials product innovation in approved to reach new patient to increase dose and indications populations duration of therapy patientforward” © 2024Novocure GmbH 7
Slide 8: Deliver pipeline
DELIVER PIPELINE GBM, glioblastoma
Slide 9: Optune Gio: established in glioblastoma
novecure’ Optune Gio: established in glioblastoma SSOOM+ 4113 ANNUAL NET REVENUE (2023) ACTIVE PATIENTS ON THERAPY* NCCN Category 1 30-40% GUIDELINE RECOMMENDATION PENETRATION IN KEY COUNTRIES reimbursement robust intellectual ACROSS MAJOR GLOBAL MARKETS property PORTFOLIO WITH MATERIAL PRODUCT DEVE
Slide 10: Optune Gio is proven to extend patient survival
novecure’ Optune Gio Is proven to extend patient survival EF-14 PHASE 3 PIVOTAL STUDY IN NEWLY DIAGNOSED GBM Overall survival (5-year survival analysis) na oon TE oA means | 229 | 160 NEARLY HALF Log-rank P-value <0,001 ° of ( + 84 HR (95% Cl) 0.63 (0.53-0.78) 43% Paes Veni] 3 - Snot Median OS fromd
Slide 11: Optune Gio: greater exposure increased survival
Optune Gio: greater exposure increased survival S 5 E z 5 90%-100% (n=43) 22-24 hours/day 70%-90% (n=257) 17-22 hours/day 60%-70% (n=46) 14-17 hours/day 50%-60% (n=42) 12-14 hours/day 0% (n=229) ‘TMZ alone 25 months P<0.05 22 months P<0.05 20 months p<0.05 mOptune Gio + TMZ "TMZ alone 18 months P-0.
Slide 12: Phase 3 LUNAR trial in NSCLC met primary endpoint
novecure’ phase 3 LUNAR trial in NSCLC met primary endpoint STATISTICALLY SIGNIFICANT AND CLINICALLY MEANINGFUL IMPROVEMENT IN OS 10 Median OS (months) 32 99 oo 4 Log-rank P-value 0.035, HR (95% Ci) 0.74 (0.56-0.98) 08 + 3-year survival (95% Cl) 18% (11-27) | 7% (2-15) TTFields g 074 *S0C I TiFields
Slide 13: NSCLC launch underway in the U.S.
novecure’ NSCLC launch underway in the U.S. 0 2023 O 2024 2025 L___ commerciaL LAUNCH REGULATORY PATHWAY v HCP and patient campaigns Y Technical file submitted in EU ¥ DTC campaign echnical file submitted in CLINICAL DATA ; ¥ Global advisory boards v¥ PMA accepted for review at FDA v Announced top-l
Slide 14: Significant opportunity to treat NSCLC patients
Significant opportunity to treat NSCLC patients 114K stage IV NSCLC 1L patients in the U.S. ~530,000 >7 YEA RS since any therapy 60% has shown a significant improvement in overall survival in 50% 2L NSCLC progress and seek 2L treatment receive 1L platinum-based chemotherapy forward © 2024 Novocure G
Slide 15: Pipeline trials in non-small cell lung cancer
PHASE 3 METIS TTFields + best supportive care treating brain NON-SMALL CELL metastases from NSCLC LUNG CANCER LUNAR-2 TTFields + pembrolizumab + chemothera| treating 1L metastatic NSCLC PHASE 2 KEYNOTE-B36 TTFields therapy + pembrolizumab treating 1L advanced or metastatic NSCLC LUNAR-4 TTFields + I
Slide 16: Significant pipeline catalysts on foundation of positive cashflow business
novecure’ Significant pipeline catalysts on foundation of positive cashflow business METIS DATA LUNG APPROVALS & LAUNCH 2024 CATALYSTS PANOVA-3 DATA PROFITABLE GBM BUSINESS patientforward* = © 2024 Novocure GmbH 16
Slide 17: Appendix
novecure’ appendix patientforward”
Slide 18: Therapy is frequency-tuned to target dividing cancer cells
novecure’ therapy is frequency-tuned to target dividing cancer cells a TUMOR TREATING FIELDS 150 kHz 200 kHz Normal ntestine Intestin | | 50kHz 100 kHz 150 kHz 200 kHz 10 kHz 250 kHz Low Frequencies Intermediate High Frequencies DNA Damage cardiac defibrillator Frequencies radiofrequency ablation io
Slide 19: TTFields have multiple, distinct mechanisms of action
novecure’ TT Fields have multiple, distinct mechanisms of action interference of disruption of 4 = , mitosis “ E mechanisms work together to selectively target and disrupt the progression of cancer cells, which can lead downregulation of - ; DNA damage : to their death response : ss. pal cell moveme
Slide 20: Optimized dose delivered can lead to increased efficacy
novecure’ optimized dose delivered can lead to increased efficacy TUMOR TREATING FIELDS DOSE DELIVERED TIME ON xX FIELD INTENSITY xX CONDUCTIVITY om, THERAPY TO TUMOR OF TISSUE — patientforwa rd” © 2024 Novocure GmbH 20 Ballo MT, et al. Correlation of Tumor Treating Fields Dosimetry to Survival Outc
Slide 21: New lighter, thinner arrays deliver greater intensity
novecure’ new lighter, thinner arrays deliver greater intensity an EXISTING ARRAYS NEW ARRAYS AP channel, 1,364 mAmps AP channel, 1,685 mAmps OV/cm PMA SUPPLEMENT SUBMITTED IN @4 2023 patientforward™ © 2024Novocure GmbH 21 ingthe as pa in vray performance data obtained from pati
Slide 22: Optune Lua and Optune Gio indications for use and important safety information
novecure’ Optune Lua® and Optune Gio® indications for use and important safety information INDICATIONS * Optune Lua® is indicated as a treatment concurrent with PD-1/PD-L1 inhibitors or docetaxel for adult patients with metastatic non-small cell lung cancer (mNSCLC) who have progressed on or after a
Slide 23: Optune Lua and Optune Gio warnings and precautions
novecure’ Optune Lua® and Optune Gio® indications for use and important safety information WARNINGS AND PRECAUTIONS. + Optune Lua and Optune Gio can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure® (the device manufacturer). + D