10x Genomics, Inc. · NASDAQ:TXG
10x Genomics — BofA Securities 2020 Healthcare Conference
45 slides from 10x Genomics's conference presentation, May 13, 2020
Slide 1: Mastering Biology to Advance Human Health
Mastering Biology to Advance Human Health Serge Saxonov CEO, Co-Founder
Slide 2: Safe Harbor Statement
Safe Harbor Statement Certain statements in this presentation and the accompanying oral commentary are “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to th
Slide 3: 10x Today
10x Today $246M 2019 revenue 68% Yearly revenue growth in 2019 1,650+ Installed instruments $150K+ Consumable pull-through 860+ Peer reviewed publications Note: Installed instruments as of 12/31/2019. Annual consumable pull-through per instrument as of FY 2019. Peer reviewed publications as of March
Slide 4: Century of Biology
Century of Biology © 10X GENOMICS, INC. 2020. 4
Slide 5: Biology is Immensely Complex
Biology is Immensely Complex 3 billion DNA bases in the genome Each cell with its own epigenetic program Transcribed into tens of thousands of mRNA molecules Each cell with a unique set of expressed genes 40 trillion cells Translated into tens of thousands of proteins Each immune cell with its own u
Slide 6: The Need for High Resolution at Massive Scale
The Need for High Resolution at Massive Scale Genomics-Led Path to Understanding Human Biology Second Phase First Phase Focus on DNA Expand to address all of biology Compile the ‘parts list’ Understand the parts and of human biology learn how to manipulate them Human Genome Project Genome wide assoc
Slide 7: Gene Expression at the Right Resolution and Scale
Gene Expression at the Right Resolution and Scale Conventional gene expression Single cell data for thousands of cells tSNE2 tSNE2 tSNE1 tSNE1 Note: t-SNE projection of approximately 10,000 mouse brain cells derived from the combined cortex, hippocampus and ventricular zones of embryonic day 18 brai
Slide 8: Major Discoveries Across Life Sciences
Major Discoveries Across Life Sciences © 10X GENOMICS, INC. 2020. 8
Slide 9: Deep Expertise Across Diverse Disciplines
Deep Expertise Across Diverse Disciplines Hardware Chemistry Biology Software Data © 10X GENOMICS, INC. 2020. 9
Slide 10: Complete Solutions
Complete Solutions Instruments Consumables Software © 10X GENOMICS, INC. 2020. 10
Slide 11: Innovation Engine
Innovation Engine Next GEM Platform Visium Platform Cell Surface CRISPR Antigen Proteins Profile Specificity Single Cell Single Cell (v3) Single Cell CNV ATAC Gene Expression High Definition Immunology Single Cell Linked-Read Gene Expression 2019 Genome Sequencing 2018 2017 Two successful acquisitio
Slide 12: Product Platforms
Product Platforms Traditional Platforms Chromium Visium . Bulk Single Cell Spatial © 10X GENOMICS, INC. 2020. 12
Slide 13: Chromium Platform: Millions of Parallel Reactions
Chromium Platform: Millions of Parallel Reactions Sample Chromium Controller Next generation Analysis and and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 13
Slide 14: Visium Platform: Rich Spatial Characterization
Visium Platform: Rich Spatial Characterization Sample Visium Next generation Analysis and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 14
Slide 15: Rapid Growth in Publications Across Life Science
Rapid Growth in Publications Across Life Science Note: Publications published based on data generated using our products. Represents cumulative publications per quarter. © 10X GENOMICS, INC. 2020. 15
Slide 16: Replacing the Legacy Toolkit Across Biology
Replacing the Legacy Toolkit Across Biology © 10X GENOMICS, INC. 2020. 16
Slide 17: Underpenetrated Market: Real-Time PCR Comparison
Underpenetrated Market: Real-Time PCR Comparison Note: 10x estimates for RT-PCR data are based on market research. Chromium instruments sold are as of December 31, 2019. © 10X GENOMICS, INC. 2020. 17
Slide 18: Creating New Markets Across Life Science Research
Creating New Markets Across Life Science Research Science and tools-based transformation of healthcare Global life science research tools $50B+ Applications where 10x offers immediate alternatives or is complementary $13B We view much of this Adoption within total market high throughput opportunity
Slide 19: Focused and Experienced Commercial Organization
Focused and Experienced Commercial Organization 97 of the top 100 global research institutions today 19 of top 20 global biopharmaceutical companies today Industry Leadership Named partner Human Cell Atlas and other large projects 1,650+ instruments sold as of December 31, 2019 Low customer concentr
Slide 20: Our Products are Being Used to Fight COVID-19
Our Products are Being Used to Fight COVID-19 • Our products allow our customers to make discoveries to understand the virus and the underlying biology of the disease, and to help develop therapies and vaccines • Some customers have been using our immune profiling solution to search for neutralizing
Slide 21: Chromium Use Case: University of Pittsburgh
Chromium Use Case: University of Pittsburgh Single cell genomics core facility supports early adoption One placement has grown to 14 Individual placements are typically shared by several labs with between 2-5 users University of Pittsburgh outsources nearly all of its sequencing to third- party prov
Slide 22: Global Commercial Footprint
Global Commercial Footprint North America EMEA APAC 55% of revenue 18% of revenue 26% of revenue High touch direct organization of 250+ FTEs with 100+ commissioned sales executives Direct in North America and most EU countries with commercial partners supporting the rest of world Note: Revenue by ge
Slide 23: 740+ Patents Issued / Filed
740+ Patents Issued / Filed Chromium Single Cell Visium Spatial Key Platforms Technologies Partitioning techniques Array designs and fabrication Barcoding assays Spatial barcoding Instrumentation and software Sample preparation Key Application Areas Gene Expression Immunology DNA Epigenomics Protein
Slide 24: Exceptional Financial Profile
Exceptional Financial Profile +49% Revenue ($mm) y/y +34% y/y 68% 2019 Revenue growth +67% +76% y/y +96% y/y +97% y/y y/y +97% +113% y/y +128% y/y y/y 2017 2018 2019 2020 $158k 1 79% 2 ~85% Instrument pull-through Gross margin Revenue from consumables2 Note: Annual consumable pull-through per instru
Slide 25: Looking Ahead
Looking Ahead © 10X GENOMICS, INC. 2020. 25
Slide 26: Chromium Single Cell ATAC + Gene Expression
Chromium Single Cell ATAC + Gene Expression • Deeply characterize cell types and states • Connect regulatory elements and gene activity • Interpret epigenetic profiles using expression markers © 10X GENOMICS, INC. 2020. 26
Slide 27: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming DNA Epigenome RNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 27
Slide 28: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming Epigenome RNA DNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 28
Slide 29: High Concordance Between the Two Read-Outs
High Concordance Between the Two Read-Outs GEX ATAC 24,000 PBMCs © 10X GENOMICS, INC. 2020. 29
Slide 30: Dive Deep Where It Matters
Dive Deep Where It Matters Discover novel disease-specific open chromatin regions ATAC Monocytes 24kb Normal B cells Tumor B cells © 10X GENOMICS, INC. 2020. 30
Slide 31: Targeted Gene Expression
Targeted Gene Expression ● More flexibility ● More scale ● More applications Single Cell Single Cell Spatial Gene Expression Immune Profiling Gene Expression © 10X GENOMICS, INC. 2020. 31
Slide 32: Targeted Gene Expression, Built the 10x Way
Targeted Gene Expression, Built the 10x Way Hybrid capture enrichment for versatile, sensitive, customizable targeting © 10X GENOMICS, INC. 2020. 32
Slide 33: Ready-to-use 10x Genomics Content Offering
Ready-to-use 10x Genomics Content Offering Fixed gene panels with comprehensive content • Tissue specific marker genes • Major signaling pathways Human Pan-Cancer Human Gene Signature • Common biomarkers ~1250 genes ~1140 genes • Disease targets for drug discovery Human Immunology Human Neuroscience
Slide 34: From Discovery to Focused Transcriptomics
From Discovery to Focused Transcriptomics Targeted product built for 10x assays Increased experimental efficiency Reduced sequencing cost WTA and targeted gene expression from the same cells Expected 80% 80%reduction reduction Core assay compatibility Content and customization © 10X GENOMICS, INC. 2
Slide 35: The Future: 10M cells
The Future: 10M cells Cells per Routine Experiment 10 100 1,000 10,000 100,000 1,000,000 10,000,000 Pre-10x 10x cells 2014 2015 2016 2017 2018 2019 2020 2021 2022 © 10X GENOMICS, INC. 2020. 35
Slide 36: Support for New Products in Cell Ranger
Support for New Products in Cell Ranger Getting to better results faster Targeted Gene Expression Cell Multiplexing Cell Ranger Enhancements • 3’ and 5’ Gene Expression •Gene Expression • Up to 4x faster runtime • Multi-sample aggregation •Immune Profiling • Dual-indexed read support • Support for c
Slide 37: Visium: Immunohistochemistry with Gene Expression
Visium: Immunohistochemistry with Gene Expression Immunohistochemistry (IHC) Visium Gene Expression IHC + Visium Gene Expression + = CD3 CD29 DAPI CD3 RNA Selected from a transcriptome Merged © 10X GENOMICS, INC. 2020. 37
Slide 38: Visium: Targeted Gene Expression
Visium: Targeted Gene Expression Whole Transcriptome, Standard Visium Reads per spot: 50,000 Pan-Cancer Panel Reads per spot: 10,000 © 10X GENOMICS, INC. 2020. 38
Slide 39: Visium: Ultra High Plex Protein Analysis
Visium: Ultra High Plex Protein Analysis Visium Protein Analysis IHC CD2 CD 9 4 © 10X GENOMICS, INC. 2020. 39
Slide 40: Immunofluorescence on Visium Feature Barcode
Immunofluorescence on Visium Feature Barcode CD29 CD4 Gene expression clustering Protein Protein mRNA mRNA mRNA CD3 CD8 CD4 © 10X GENOMICS, INC. 2020. 40
Slide 41: Visium: FFPE on Spatial Gene Expression
Visium: FFPE on Spatial Gene Expression FFPE Recently fixed 7-year archival Standard tissue preservation Mouse brain Breast cancer © 10X GENOMICS, INC. 2020. 41
Slide 42: 10x Genomics Cloud: Launching in 2020
10x Genomics Cloud: Launching in 2020 Cell Ranger, Space Ranger, Loupe in the cloud Zero-stress compute infrastructure Easy-to-use UI, and fast Scalable and elastic Standard analysis included with reagent purchase © 10X GENOMICS, INC. 2020. 42
Slide 43: Best Compute Experience for 10x Software
Best Compute Experience for 10x Software 15-20 hrs ~ $10 < 10 hrs No Cost 1 hr On-Prem DIY 10x Genomics Hardware Cloud Cloud Analysis (expected) © 10X GENOMICS, INC. 2020. 43
Slide 44: Towards a Comprehensive View of Biology
Towards a Comprehensive View of Biology Gene Expression Immunology DNA Epigenomics Proteins Chromium Single Cell Visium Spatial © 10X GENOMICS, INC. 2020. 44
Slide 45: © 10X GENOMICS, INC. 2020.
© 10X GENOMICS, INC. 2020. 45
10x Genomics — BofA Securities 2020 Healthcare Conference on 6ix