Slide 1: Investor Presentation May 2012
™ MRI INTERVENTIONS >) Ticker: MRIC Investor Presentation May 2012
Slide 2: Forward-Looking Statements
Forward-Looking Statements Certain matters in this presentation may constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21£ of the Securities Exchange Act of 1934. Forward- looking statements often can be identified by words such as “anti
Slide 3: MRI Interventions, Inc. (MRIC) Opportunity Highlights
MRI Interventions, Inc. (MRIC) Creating MRI-based interventional platforms for the next generation of minimally invasive surgical procedures. OPPORTUNITY HIGHLIGHTS = ClearPoint® Neuro Intervention System, first-to-market platform, allows neurosurgeons to see inside the patient’s brain during a proc
Slide 4: Minimally Invasive Procedures: A Revolution Driven by Imaging
Minimally Invasive Procedures: A Revolution Driven by Imaging Imaging Modality Resulting Minimally Invasive Platform
Slide 5: Visualization is the Fundamental Building Block
Visualization is the Fundamental Building Block Keystone for minimally invasive procedures is intra-procedural visualization. This capability wasn’t available for neurosurgery until ClearPoint. Conventional Procedure ClearPoint Platform Surgeon sees the outside of Provides detailed visualization, in
Slide 6: ClearPoint: MRI-guided Neuro Intervention System
ClearPoint: MRI-guided Neuro Intervention System First-to-Market FDA-Cleared, CE-Marked Built on the Imaging Power of MRI LEARPOINT Enables Surgeons to: = See inside the brain during procedures in real-time. = Reach very small neuro targets, deep within the brain, with millimetric precision. = Obser
Slide 7: Support from Clinicians, Industry, and Academics
Support from Clinicians, Industry, and Academics Leading industry partners, academic institutions, and cl jans support MRIC technology and its application across multiple specialties. INDUSTRY PARTNERS CLINICIAN ADVISORS SIEMENS #BrainLAB Boston, Scientific UNIVERSITY RESEARCH “i y Ween DePhilpStar
Slide 8: ClearPoint Neuro Intervention System
ClearPoint® Neuro Intervention System OVERVIEW = ClearPoint procedures are performed ina hospital’s existing MRI suite (diagnostic or intraoperative). There are over 4,500 such scanners in hospitals throughout the U.S. = ClearPoint is an integrated platform of reusable hardware, software, and dispos
Slide 9: ClearPoint Procedure Overview
ClearPoint Procedure Overview Standard MRI Suite NE ClearPoint Standard Diagnostic _ClearPoint imaging Coil and Workstation Monitor MARI Scanner Fixation Frame
Slide 10: ClearPoint Procedure Cont.
ClearPoint Procedure Cont. Target Selection & Entry Planning
Slide 11: ClearPoint Procedure Cont.
ClearPoint Procedure Cont. SmartFrame Trajectory Guide Trajectory Alignment & Device Insertion
Slide 12: ClearPoint Procedure Cont.
ClearPoint Procedure Cont. ClearPoint: A Breakthrough Platform for Minimally Invasive Neurosurgery ..Now the Neurosurgeon can See
Slide 13: The ClearPoint Difference
The ClearPoint Difference Conventional Procedure ClearPoint Procedui No direct visualization, Direct, high resolution visualization, Performed in an operating room Performed in an MRI Suite Patient often must be awake for their Patient under general anesthesia own brain surgery Long procedures — up
Slide 14: ClearPoint Economics
ClearPoint Economics BUSINESS MODEL — RAZOR / RAZORBLADE = ClearPoint Hardware/Software: $180,000 ASP (paid upfront or over time). ClearPoint Disposables: $7,300 ASP per procedure with strong margins. Generate recurring revenue from the sale of disposables. Procedures covered by existing reimburseme
Slide 15: Market Opportunity for Minimally Invasive Neurosurgery
Market Opportunity for Minimally Invasive Neurosurgery Addressable Patient Population Therapeutic Approaches Parkinson's Disease | 1,500,000 150,000 Today Inttrials Today Epilepsy 2,300,000 250,000 Intrials Inttrials Today Brain Tumor 200,000 10,000 N/A Intrials Today coco 3,300,000 100,000 Today In
Slide 16: ClearPoint Adoption
ClearPoint Adoption CURRENT INSTALLED BASE r) UNIVERSITY OF UTAKL HEALTH CARE Cincinn: Hospital Medical Cemer| Metha@list The Methodist =! Hospital New Haven Menor Sor Kereing (Cancer Center oe ps @ EMORY <HEALTIICARES Plus, 1* site in Europe - Warsaw tr Presentation
Slide 17: Neurosurgeon Comments on ClearPoint
Neurosurgeon Comments on ClearPoint The ClearPoint System “represents a major step forward in our ability to treat complex neurological diseases." Dr. Paul Lafson “Yesterday's [ClearPoint case] was 2 hours and 45 Wy tf) oe minutes, compared to about 6 hours for the standard approach,” ..some can tak
Slide 18: ClearPoint Market Opportunity
ClearPoint Market Opportunity HIGHLIGHTS Cuting- Edge interventional MRI System Tansterms Brin Surgery for Parkinsons Pes "= First-to-market in U.S. and Europe = Strong support from leading clinicians = Growing ClearPoint market awareness = 4,500 MRI scanners in U.S. hospitals = 3,500 neurosurgeons
Slide 19: Our Next Platform in Development
Our Next Platform in Development ClearTrace™ Cardiac intervention System for minimally invasive surgical procedures in the heart. Intra-procedural Visualization: Current Procedure vs. ClearTrace Current Procedure ClearTrace System ‘CAUTION: mesigotonadeice Unites by fede ow to ines! ue
Slide 20: Personnel and Infrastructure
Personnel and Infrastructure Research, development, manufacturing, and fulfillment takes place in the Company’s ISO-certified facility in Irvine, CA PERSONNEL = 20 Employees = 15+ years average med device experience INFRASTRUCTURE = Product development and prototyping performed in-house = Product as
Slide 21: Financial Highlights
Financial Highlights MRIC is a commercial stage company, anticipating strong growth from its ClearPoint product line in 2012 and beyond. $60M has been invested in MRIC, primarily research and development, since inception in 1998. FINANCIAL RESULTS 2010 Results 2011 Results = Pre-Revenue = $1.2M in p
Slide 22: Near Term Growth Drivers
Near Term Growth Drivers HIGHLIGHTS = Growth in ClearPoint installations - driven by the hiring of additional sales and clinical support personnel, and positive PR from ClearPoint cases. = Growth in ClearPoint procedures - driven by an expanding installed base, increased physician acceptance, and pr
Slide 23: MRI Interventions, Inc.
™_ M-~I1 INTERVENTIONS > Ticker: MRIC MRI Interventions, Inc. One Commerce Square, Suite 2550 Memphis, TN 38103 (901) 522-9300 info@mriinterventions.com
Slide 24: Descriptions of the Videos Included in this Presentation
Descriptions of the Videos Included in this Presentation This presentation includes three embedded videos. The following table provides the location of each video in the presentation and a description of each video: This video depicts the target selection and entry planning portion ofa learPoint pro
Slide 25: ClearPoint Neuro Intervention System
ClearPoint Neuro Intervention System ClearPoint Draping in Preparation for a Case in a Diagnostic MRI Suite Presentation
Slide 26: ClearPoint Neuro Intervention System
ClearPoint Neuro Intervention System Selected ClearPoint Disposable Components a nterventions Investor Presentation 2