Slide 1: Introducing Evogene
1 Introducing Evogene 18 June, 2014 Ofer Haviv President & CEO
Slide 2: Forward-looking statements
This presentation contains "forward-looking statements" relating to future events, and we may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting Evogene Ltd. or its subsidiaries (collect
Slide 3: Table of contents
Who we are Areas of activity Corporate and financial overview Summary Table of contents 1. 2. 3.
Slide 4: Our mission
Our mission ¢ To improve plant productivity and performance by harnessing the power of plant genomics Products and end -markets ¢ Core business - seed traits: biotech seeds ( c.$20bn ) and conventional seeds ( c.$19bn ) ¢ Emerging businesses: ag-chemicals ( c.$54bn ) and second generation feedstock
Slide 5: The challenge and opportunity
The challenge: producing more with less The solution: increasing plant productivity and performance The opportunity: utilizing plant genomics to improve plant productivity The challenge and opportunity World population (in billions) I Source: United States Census Bureau. Hectares per capita, globall
Slide 6: Our technology drives our business
Seed traits Ag-chemicals Seeds - Evofuel Our technology drives our business Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü Insect resistance Stra
Slide 7: Our business
Our core business Our emerging businesses Our business Seed traits ¢ Yield and abiotic stress ¢ Biotic stress Ag-chemicals Seeds ¢ We focus on traits with the highest economic value for farmers ¢ We identify genes linked to key traits and license them to seed companies ¢ Our partners develop and pla
Slide 8: Our revenue model
§ R&D payments paid by partner in the majority of our collaborations § Additional payments received upon achieving predetermined objectives § Potential royalties vary on average between 5%-12% of future trait sales § Revenue from direct castor bean seed sales anticipated from 2016 onwards Seed trait
Slide 9: Development timeline and phases
Y0 Y1 Y2 Y3 Y4 Y5 Y6 Y7 Y8 Y9 Y10 Y11 Y12 Y13 Y14 Y15… Discovery Note: Average duration may overlap and could be longer or shorter than estimated, depending on a range of factors, including, but not limited to, the type of crop and trait involved. Any results, estimates, or calculations relating to
Slide 10: Partnerships with world leading seed companies
2013 2011 2008 2007 2013 2011 2007 2013 2009 2010 2009 2007 2010 ¢ >10 collaboration agreements ¢ Portfolio of 23 product programs across various crops and traits ¢ 100s of genes being developed in partners’ pipelines ¢ Most advanced genes in Phase 2 ¢ Monsanto as a strategic shareholder holding c.9
Slide 11: Our unique position in genomic Big Data
Widening spectrum of data types and sources Growing amount of data Declining cost of data production The key challenge in the industry has shifted from data generation to data integration and analysis Our unique position Solving the industry bottleneck - integration and analysis of genomic ‘Big Data
Slide 12: Our technology platform
Gene Microbial Raw data Integrated database Output Proprietary and public raw datasets Optimize gene efficacy and product success Elements for efficacy Breeding enhancement Molecular markers to enhance breeding Genes impact traits Identify novel targets Genes serving as targets • Over 200 plant spec
Slide 13: Table of contents
Who we are Areas of activity Corporate and financial overview Summary 1. 2. 3. Table of contents
Slide 14: Our technology drives our business
Seed traits Ag-chemicals Seeds - Evofuel Our technology drives our business Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü Insect resistance Stra
Slide 15: Seed traits - yield and abiotic stress: collaborations to date
Yield and drought Yield, drought and fertilizer Yield and drought Yield, drought, and fertilizer Yield Yield, drought and fertilizer Yield and drought Drought and fertilizer Yield, drought and fertilizer A. Seed traits - yield and abiotic stress Collaborations to date ( 1) Biogemma is a wholly owned
Slide 16: Yield & abiotic stress product program pipeline
Corn 1. Yield 2. Abiotic stress 3. Nitrogen use efficiency 4. Yield 5. Abiotic stress 6. Yield 7. Abiotic stress 8. Nitrogen use efficiency 9. Yield 10. Abiotic stress 11. Nitrogen use efficiency 12. Yield 13. Abiotic stress 14. Nitrogen use efficiency 15. Yield 16. Abiotic stress 17. Nitrogen use e
Slide 17: Collaboration with Monsanto
Gene discovery and trait optimization by Evogene Development and commercialization by Monsanto Collaboration with Monsanto Focus on yield and abiotic stress - Aug. 2008, extended Nov. 2011 and Oct. 2013 ¢ 8 Year collaboration ¢ Traits - yield, drought tolerance, fertilizer utilization ¢ Biotic stres
Slide 18: Current focus and future value drivers
Potential value drivers Current focus and future opportunities Phase advancements Strengthen R&D leadership New crops/traits (e.g. vegetables/yield) Legend ( 1) Scope of rice activity currently limited. A. Seed traits - yield and abiotic stress Current focus and future value drivers Corn, soybeans W
Slide 19: Seed traits - biotic stress: collaborations and programs
Soybean cyst nematode Banana black sigatoka Soybean rust Soybean cyst nematode Soybean rust Fusarium resistance Soybean Aphids Corn Rootworm B. Seed traits - biotic stress Collaborations and programs to date
Slide 20: Biotic stress product program pipeline
Corn 1. Fusarium 2. Rootworm Soybean 3. Asian Rust 4. Nematode 5. Aphids Banana 6. Black Sigatoka Discovery Crop Trait Partner Biotic stress - current product program pipeline Note: Any results, estimates, or calculations relating to probability of success at each phase of development may differ fro
Slide 21: Collaboration with Syngenta
Gene discovery by Evogene Development and commercialization by Syngenta ¢ Research period extended to March 2017 ¢ Trait - Soybean Cyst Nematode (SCN) Resistance ¢ Main crop - soybean ¢ R&D reimbursement by Syngenta ¢ Milestone payments + royalties based on sales Model and target plant validation an
Slide 22: Biotic stress: current focus and future value drivers
Potential value drivers Current focus and future opportunities Phase advancements Extend into new traits e.g. additional insect resistance programs R&D platforms extension B. Seed traits - Biotic stress Current focus and future value drivers Soybean Banana Wheat Crops Fungi resistance Insect resista
Slide 23: Ag-chemicals: combining biology and chemistry
Combining biology and chemistry to drive innovation C. Ag-chemicals Market and activity to date Chemistry + ¡ Initiated in 2012, ag-chemicals is a new field for Evogene ¡ Discovery initiated - identifying targets within plant that can be inhibited by herbicides ¡ Dedicated computational platforms un
Slide 24: Ag-chemicals: current focus and future value drivers
Potential value drivers Current focus and future opportunities Herbicides / crop enhancers discovery Collaborations with ag-chemicals companies Novel herbicide targets and hits New fields - ag-biologicals Legend C. Ag-chemicals Current focus and future value drivers Ag-Chemicals Ag-Biologicals Appli
Slide 25: Evofuel market
Current market: industrial uses Future market: Biodiesel Leveraging plant genomics capabilities to plant-based industries D. Evofuel Market Source: OECD and FAO Secretariats, Agricultural outlook 2011-2020, as of June 15, 2011. Long term use n Second generation feedstock for biodiesel The need n Cos
Slide 26: Evofuel activity to date and future value drivers
Brazil commercial sales Strategic downstream collaborations Development of next-generation varieties (no-ricin) Commercialization of advanced castor varieties expected in 2016 D. Evofuel Activity to date and future value drivers § >5 million ha. potential for castor large scale production in Brazil
Slide 27: Table of contents
Who we are Areas of activity Corporate and financial overview Table of contents 1. 2. 3.
Slide 28: Corporate and financial overview
ה Corporate and financial overview ¢ Corporate Identity ¢ Key milestones: ¢ 2002 - spins off from Compugen (NASDAQ:CGN) ¢ 2007 - lists on TASE (EVGN) ¢ 2013 - lists on NYSE (EVGN) ¢ Market cap (1) c.$420m , c.25m shares outstanding ¢ 200 FTEs , 87% R&D positions ¢ Cash position ¢ c.$124m in cash, ca
Slide 29: Summary
Summary Multiple future value drivers Strategic position in plant genomics - engine for agricultural innovation Unique technology platform, combining expertise in plant science and cutting-edge computational tools Diversified product portfolio with multiple paths of commercialization Partner of choi
Slide 30: Thank You!
30 Thank You!
Slide 31: Agriculture Productivity - Market and Offering
1 Agriculture Productivity - Market and Offering 18 June, 2014 Ido Dor, Director Business Development
Slide 32: Forward-looking statements
This presentation contains "forward-looking statements" relating to future events, and we may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting Evogene Ltd. or its subsidiaries (collect
Slide 33: Table of contents
Agriculture productivity Evogene’s offering Summary Summary Table of contents 1. 2. 3.
Slide 34: Ag productivity market drivers
Decreasing arable land per capita Change in agricultural yields Importance of productivity Maintaining and accelerating agricultural productivity is a central component of achieving global food and nutrition security (Hectares per capita, globally) 10-year rolling average change in yield (1) Source:
Slide 35: Ag productivity - grower's point of view
Corn production costs - $ per acre - 2012,13 US average Ag Productivity - Grower’s Point of View Example - corn Total cost Value less cost Total value Agriculture productivity inputs Fertilizer Other operational cost Allocated overhead Source: USDA Economic Research Services Ag chemicals Seed
Slide 36: A combined market of ~$94B
A combined market of ~$94B Seeds - ~$40B market Ag Chemicals - $54B market ‘Seed internal’ (traits & seeds) Impacting ag productivity by improving the seeds ‘Beyond the seed’ Impacting ag productivity by applications applied externally Source: Phillips McDougall, 2013
Slide 37: Table of contents
Agriculture productivity Evogene’s offering Summary Summary Table of contents 1. 2. 3.
Slide 38: Evogene's offering
Seed traits Ag-chemicals Seeds - Evofuel Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü Insect resistance Unique technology platform combining ex
Slide 39: Commercial seeds market
Biotechnology-based crops are growing at ~18% per year since the technology became commercial in the late 1990s Commercial Seeds Market Global market development 2003 - 2013 (US$ in millions) Source: Phillips McDougall. +9% 39,425 37,560 34,495 30,820 27,755 26,020 21,710 20,340 19,752 19,000 17,230
Slide 40: Seven industry leaders responsible for ~64% of seed market
Seven industry leaders responsible for ~64% of seed market Industry Leaders Commercial seed sales (US$ millions, 2012) Source: Phillips McDougall, 2012
Slide 41: Generating revenues from biotech seeds
Trait Estimated trait value (US$m) Yield & abiotic stress Yield - Corn >1,500 Fertilizer Utilization - Corn >1,000 Drought Tolerance - Corn >500 Biotic - disease resistance Fusarium stalk rot resistance - corn <200* Rust resistance - Soybean >500 Trait Estimated trait value (US$m) Biotic - insect re
Slide 42: Evogene's offering
Seed traits Ag-chemicals Seeds - Evofuel Strategic Position In Plant Genomics Evogene’s offering Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü I
Slide 43: Seed traits - yield and abiotic stress: value drivers
Potential value drivers Current focus and future opportunities Phase advancements Strengthen R&D leadership New crops/traits (e.g. vegetables/yield) Legend ( 1) Scope of rice activity currently limited. Seed traits - yield and abiotic stress Current focus and future value drivers Corn, soybeans Whea
Slide 44: Gene2Product Platform
Gene2Product Platform Gene optimization
Slide 45: Evogene's offering
Seed traits Ag-chemicals Seeds - Evofuel Strategic Position In Plant Genomics Evogene’s offering Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü I
Slide 46: Seed traits - biotic stress: value drivers
Potential value drivers Current focus and future opportunities Phase advancements Extend into new traits e.g. additional insect resistance programs R&D platforms extension Seed traits - Biotic stress Current focus and future value drivers Soybean Banana Wheat Crops Fungi resistance Insect resistance
Slide 47: Insect Resistance
Insect Resistance A new field for Evogene
Slide 48: Insect resistance market
Growing Market Emerging Resistance BT - One Solution Does Not Fit All BT Focused Solutions - Confidential - Source: Phillips McDougall Insect Resistance Market Need for novel solutions “Stink bug population spreading across USA” USA Today, 3/25/11 n Novel products in pipelines include several MOAs:
Slide 49: Insect resistance GM solutions
Rootworm - Corn Aphids - Soybean - Confidential - Insect Resistance GM Solutions Products of focus § Top insect for major crop - trait value estimated at >$500M* § No biotechnology solutions § Partner indication for need § Relevant across crops - Soy è Corn è Cotton § Other top insects from order §
Slide 50: Evogene's offering
Seed traits Ag-chemicals Seeds - Evofuel Strategic Position In Plant Genomics Evogene’s offering Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü I
Slide 51: The Ag Chemicals market
Market development 2003-2013 The science of crop protection is expanding beyond traditional Ag Chemicals to include new technologies to develop more effective products Ag Chemical Segments 2013 - $54B Sales (US$ in millions) The Ag Chemicals Market Key market figures +7% 54,208 +9% 49,548 Source: Ph
Slide 52: Six industry leaders ~80% of Ag Chemicals market
Six industry leaders are responsible for ~80% of the Ag Chemicals market Industry Leaders Ag chemicals sales (2013) Source: Phillips McDougall Source: Phillips McDougall
Slide 53: Ag-chemicals: current focus and future value drivers
Herbicides / crop enhancers discovery Potential value drivers Current focus and future opportunities Collaborations with ag-chemicals companies Novel herbicide targets and hits New fields - Ag-Biologicals Ag-Chemicals Legend Ag-chemicals Current focus and future value drivers Current focus Future op
Slide 54: The herbicide industry
No new herbicide with a new ‘Mode of Action’ introduced in the past 20 years Growing need for innovation Weed resistance is soaring Regulation pressure The Herbicide Industry The need Source: Phillips McDougall. # Modes of Action (MOA) available Source: WSSA. # of species with multiple resistance
Slide 55: Convergence of plant biology and chemistry
Biology Validation of new MOA Chemistry Convergence of Plant Biology and Chemistry First milestone achieved Novel herbicides
Slide 56: Ag-chemicals: current focus and future value drivers
Potential value drivers Current focus and future opportunities Herbicides / crop enhancers discovery Collaborations with ag-chemicals companies Novel herbicide targets and hits New fields - ag-biologicals Ag-chemicals Current focus and future value drivers Legend Current focus Future opportunities A
Slide 57: Ag-Biologicals
Ag-Biologicals M&As & collaborations Estimated to reach ~ $7.5B by 2020 Short Time to Product, Significantly Lower Development Cost Microbial Collection Bio- Stimulant Ag-Biologicals The market Piper Jefferie's growth estimates 4-7 years, $5M-$8M Source: Internal Evogene estimates
Slide 58: Evogene's offering
Seed traits Ag-chemicals Seeds - Evofuel Strategic Position In Plant Genomics Evogene’s offering Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü I
Slide 59: Evofuel - seed company
Current market: industrial uses Strategic market: Biodiesel Soybean & castor oil prices in past year Evofuel - Seed Company Castor bean - first crop of focus n Existing industries: biopolymers, lubricants, paints, etc. n Global production 2013: c.650,000 ton à rigid demand n Main exporters: EU, U.S.
Slide 60: From seed to product
Grower Seed supplier ¡ Supply high performing seed varieties ¡ Know how on modern cultivation (mechanized harvest, chemicals, etc.) ¡ Industry exists - currently relaying on soybean (~85% in Brazil) ¡ Seeking for new feedstock ¡ Large scale agri-businesses seeking for new crops - improve economics &
Slide 61: Evofuel activity to date and future value drivers
Brazil commercial sales Potential value drivers Strategic downstream collaborations Development of next-generation varieties (no-ricin) Commercialization of advanced castor varieties expected in 2016 Evofuel Activity to date and future value drivers n Key markets: Brazil and Argentina n >5 million h
Slide 62: Unique agricultural opportunity: SLC collaboration
Commercial production of castor under SLC collaboration expected in 2016 SLC background Unique Agricultural Opportunity Rotation model with soybean Corn cultivated Area Primary Soy regions Secondary Soy regions Soy expansion regions Source: Internal Evogene estimates n Large scale agribusiness n man
Slide 63: Recent Updates
Recent Updates Achievement of development and commercialization milestones
Slide 64: Table of contents
Agriculture productivity Evogene’s offering Summary Summary Table of contents 1. 2. 3.
Slide 65: Potential addressable market of ~$94B
Utilizing plant genomics to improve plant productivity - potential addressable market of ~$94B 57,595 52,848 81,034 93,633 87,108 52,566 51,204 45,191 72,111 67,902 69,207 Ag Chemicals Seeds and seeds traits Agriculture Productivity Inputs Seeds and Ag Chemicals market development 2003-2013 (US$ in
Slide 66: Main value drivers
Seed traits Ag-chemicals Seeds - Evofuel Brazil commercial sales Strategic downstream collaborations Development of next-generation varieties (no-ricin) Herbicides / crop enhancers discovery Collaborations with ag-chemical companies Novel herbicide targets and hits New fields - ag-biologicals Phase
Slide 67: Thank You!
37 Thank You!
Slide 68: Evogene Technology Platform
1 Evogene Technology Platform 18 June, 2014 Dr. Alin Sela-Brown Director, Labs and QA
Slide 69: Agenda
Introduction Technology Platform Units Integration & Synergy Summary Confidential Agenda 1. 2. 3. 4.
Slide 70: Our technology drives our business
Seed traits Ag-chemicals Seeds - Evofuel Our technology drives our business Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü Insect resistance Stra
Slide 71: Our technology drives our business
Seed traits Our technology drives our business Ag-chemicals Seeds - Evofuel Yield and abiotic stress ü Yield ü Drought tolerance ü Fertilizer utilization Ag-chem ü Herbicides ü Crop enhancers Proprietary seeds ü Castor bean Biotic stress ü Plant disease ü Nematode resistance ü Insect resistance Stra
Slide 72: Agenda
Introduction Technology Platform Units Integration & Synergy Summary Agenda 1. 2. 3. 4.
Slide 73: Technology platform internal structure
Computational Genomics IT & Data Management Labs & Tissue Culture Technology Platform Internal Structure Algorithms Molecular lab Tissue culture Seed propagation Seed bank Model plant Target plant IT Information Management Systems Imaging & Data analysis Phenotyping & sampling QA Development Bioinfo
Slide 74: Novel algorithms & methodologies
Novel algorithms & methodologies Multi disciplinary background with deep understanding in biology & computers Development Algorithms Bioinformatics Computational Genomics Computational product development 10s of software modules: architecture, user interface, through-put performance, software engine
Slide 75: Technology platform internal structure
Computational Genomics IT & Data Management Labs & Tissue Culture Technology Platform Internal Structure Algorithms Molecular lab Tissue culture Seed propagation Seed bank Model plant Target plant IT Information Management Systems Imaging & Data analysis QA Development Bioinformatics
Slide 76: Labs & Tissue Culture
Labs & Tissue Culture Transformation & Validation assays Arabidopsis , Brachypodium, Tomato, Canola 6,000 transformed plants each year Molecular Lab Tissue culture Supporting special requirements of Evogene research activity: § Preparation of hundreds of DNA, RNA & special NGS libraries § HTP genoty
Slide 77: Technology platform internal structure
Computational Genomics IT & Data Management Labs & Tissue Culture Technology Platform Internal Structure Algorithms Molecular lab Tissue culture Seed propagation Seed bank Model plant Target plant IT Information Management Systems Imaging & Data analysis QA Development Bioinformatics
Slide 78: Management of seed inventory and regulation species
Management of seed inventory and regulation 79 species 4,273 imported lines Import / export - new lines are introduced each year Propagation of seed Core Collections 15 crops, 7 Core collection, support over 40 experiments and field trials Experiment growth activity and phenotypic collections 40 exp
Slide 79: Technology platform internal structure
Computational Genomics IT & Data Management Labs & Tissue Culture Technology Platform Internal Structure Algorithms Molecular lab Tissue culture Seed propagation Seed bank Model plant Target plant IT Information Management Systems Imaging & Data analysis QA Development Bioinformatics
Slide 80: Information Technology & Data Management
Information Technology & Data Management Computational, backup & information security Develop CPU clusters and storage for Bioinformatics needs Over 1.2 Peta managed data , Over 830 CPU cores IT Process & information flow Oracle BPM technology - modeling platform processes Online high throughput pho
Slide 81: Agenda
Introduction Technology Platform Units Integration & Synergy Summary Agenda 1. 2. 3. 4.
Slide 82: Arabidopsis Model Plant Validation
Arabidopsis Model Plant Validation RACE and cloning Transformation Plant growth Seed collection TC Validation Data Collection Data analysis IMS GH Validation Day 1 Day 3 Day 5 Day 8 Day 10 Day 12 Day 15…. Day 28 Image Processing Data Processing Image Acquisition Validation Technologies Plant POC exa
Slide 83: Agenda
Introduction Technology Platform Units Integration & Synergy Summary Agenda 1. 2. 3. 4.
Slide 84: Expanding Infrastructure
Expanding Infrastructure
Slide 85: Expanding Infrastructure
Nov 2012 Expanding Infrastructure
Slide 86: People
People
Slide 87: Thank You!
20 Thank You!