Evotec Se · XETR:EVT

Evotec — Fact Sheet

2 slides from Evotec's fact sheet

1. Slide 1: Monoamine Oxidase (MAO) Reaction Phenotyping

   In vitro ADME & PK Monoamine Oxidase (MAO) Reaction Phenotyping Background Information Protocol • Monoamine oxidases (MAO) are Test System membrane-associated enzymes located hMAO-A and hMAO-B expressed enzyme specifically on the outer mitochondrial membrane. They are the major enzymes Test Article

2. Slide 2: Metabolic stability of MAO substrate kynuramine

   Monoamine Oxidase (MAO) is a critical enzyme in the degradative deanimation of biogenic amines throughout the body1. Figure 1 Metabolic stability of the MAO substrate kynuramine over 45 min in the presence of MAO-A and MAO-B expressed enzyme (each data point is mean of n=3). 5 4.5 MAO-A In % Remaini

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