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Quanterix Announces Landmark JAMA Study Highlighting Prognostic Value of Multi-Analyte Approach to Blood-Based Alzheimer’s Risk Profiling
BILLERICA, Mass., January 21, 2026--Quanterix Corporation (NASDAQ: QTRX), a company transforming healthcare by accelerating biomarker breakthroughs from discovery to diagnostics, today announced publication of a landmark study in the high impact journal JAMA Network Open, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2842215. The study, led by researchers at Amsterdam UMC, followed a cohort of nearly 300 individuals for up to 15 years. The findings demonstrated that while individu
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[{"type":"text","content":"Analysis of Subjective Cognitive Decline (SCD) cohort indicates that combining biomarkers representing four key biological axes—amyloid, tau, neurodegeneration, and neuroinflammation—provides a superior window into disease progression at the earliest stages","length":257,"tagName":"p"},{"type":"text","content":"BILLERICA, Mass., January 21, 2026--(BUSINESS WIRE)--Quanterix Corporation (NASDAQ: QTRX), a company transforming healthcare by accelerating biomarker breakthroughs from discovery to diagnostics, today announced publication of a landmark study in the high impact journal JAMA Network Open, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2842215. The study, led by researchers at Amsterdam UMC, followed a cohort of nearly 300 individuals for up to 15 years. The findings demonstrated that while individual biomarkers provide a baseline snapshot of pathology, the combination of multiple markers at baseline—along with their subsequent longitudinal trajectories—offers a significantly more comprehensive view of clinical risk.","length":739,"tagName":"p"},{"type":"text","content":"The research utilized ultra-sensitive Simoa® technology to measure biomarkers representing the four critical biological axes of Alzheimer’s disease: amyloid (Aβ42/Aβ40 ratio), tau (p-Tau 217), neuroinflammation (GFAP), and neurodegeneration (NfL). A primary conclusion of the study was that the most accurate assessment of clinical progression was achieved through a multi-analyte model, both at baseline as well as through longitudinal monitoring of individual biomarker values. The optimal model achieved a C-index of 0.90 (1.0 being perfect accuracy) for identifying individuals with SCD—the earliest stage where patients notice potential changes that are undetectable in objective cognitive testing–most likely to progress toward clinical impairment. The data showed that even a single baseline measurement of this specific multi-analyte panel offered a distinct prognostic advantage over standalone p-Tau 217 assays.","length":921,"tagName":"p"},{"type":"text","content":"This JAMA paper highlights how Quanterix’s Simoa® ultra-sensitive technology and multiplexed biomarker assays are powering advances in Alzheimer’s disease research, which is becoming increasingly focused on evaluating multiple biomarkers and multiple disease pathways. Quanterix is als...