Business

Signatera™ MRD Data at ASCO GU Highlights Potential Utility Across GU Cancers, Including for Bladder Preservation

AUSTIN, Texas, February 27, 2026--Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced it will present new data in genitourinary malignancies at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), taking place February 26-28, 2026.

articleNatera, Inc.February 27, 20265/company/natera-inc/news/signateratm-mrd-data-at-asco-gu-highlights-potential-utility-across-gu-cancers-including-for-bladder-preservation
Signatera™ MRD Data at ASCO GU Highlights Potential Utility Across GU Cancers, Including for Bladder Preservation

About this update from Natera, Inc.

[{"type":"image","alt":"","displaySize":"","headline":null,"caption":"","credit":null,"className":"","disableSlideshowImg":false,"size":{"original":{"width":200,"height":200,"url":"https://media.zenfs.com/en/business-wire.com/34457b90e8f910cb636c9fbfb13abc10"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/ywxgMI6YiQAvnsgK_YB3FA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTM2MDtoPTM2MDtjZj13ZWJw/https://media.zenfs.com/en/business-wire.com/34457b90e8f910cb636c9fbfb13abc10","width":200,"height":200}},"lazy":false},{"type":"text","content":"11 scientific abstracts, including 4 oral presentations and a concurrent publication in Nature Medicine, underscore how Signatera MRD can improve quality of life for patients with genitourinary cancers","length":201,"tagName":"p","attribs":{}},{"type":"text","content":"AUSTIN, Texas, February 27, 2026--(BUSINESS WIRE)--Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced it will present new data in genitourinary malignancies at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), taking place February 26-28, 2026.","length":330,"tagName":"p"},{"type":"text","content":"Across four oral presentations in muscle-invasive bladder cancer (MIBC), these data reinforce Signatera’s role in identifying patients who benefit from adjuvant immunotherapy, supporting response-adaptive bladder preservation strategies, and refining molecular residual disease (MRD) detection with plasma circulating tumor DNA (ctDNA) and urinary tumor DNA (utDNA).","length":366,"tagName":"p"},{"type":"text","content":"Bladder Preservation: INDIBLADE and RETAIN","length":42,"tagName":"p"},{"type":"text","content":"The INDIBLADE and RETAIN multicenter phase 2 trials demonstrate Signatera’s consistent performance in treatment response monitoring across diverse neoadjuvant regimens in MIBC, with 73-77% of patients demonstrating clearance of ctDNA following therapy and Signatera-negativity showing strong associations with positive outcomes, even with the bladder preserved.","length":361,"tagName":"p"},{"type":"text","content":"INDIBLADE, the findings of which will be published today in Nature Medicine, investigated induction with combination immune checkpoint inhibitors (ICI) followed by chemoradiotherapy as a bladder-sparing strategy in stage II/III MIBC patients. The results show that Signate...

More updates from Natera, Inc.

neoadjuvant therapyASCO GU