Business

MTVA: Positive Results for 48 mg Cohort in Phase 1b Trial of DA-1726…

By David Bautz, PhD NASDAQ:MTVA READ THE FULL MTVA RESEARCH REPORT Business Update Positive Results for 8-week 48 mg Cohort in Phase 1b Trial of DA-1726 On January 5, 2026, MetaVia, Inc. (NASDAQ:MTVA) announced positive and statistically significant results from the 8-week 48 mg cohort from the Phase 1b trial of DA-1726, the company’s dual oxyntomodulin analog that functions as a glucagon-like

articleMetavia Inc.January 21, 20266/company/metavia-inc/news/mtva-positive-results-for-48-mg-cohort-in-phase-1b-trial-of-da-1726
MTVA: Positive Results for 48 mg Cohort in Phase 1b Trial of DA-1726…

About this update from Metavia Inc.

[{"type":"text","content":"By David Bautz, PhD","length":19,"tagName":"p"},{"type":"text","content":"NASDAQ:MTVA","length":11,"tagName":"p"},{"type":"text","content":"READ THE FULL MTVA RESEARCH REPORT","length":34,"tagName":"p"},{"type":"text","content":"Business Update","length":15,"tagName":"p"},{"type":"text","content":"Positive Results for 8-week 48 mg Cohort in Phase 1b Trial of DA-1726","length":69,"tagName":"p"},{"type":"text","content":"On January 5, 2026, MetaVia, Inc. (NASDAQ:MTVA) announced positive and statistically significant results from the 8-week 48 mg cohort from the Phase 1b trial of DA-1726, the company’s dual oxyntomodulin analog that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR) agonist. The results showed a robust reduction in weight and waist circumference, along with large improvements in glucose control and reductions in liver stiffness. The drug also continued to be safe and well tolerated.","length":520,"tagName":"p"},{"type":"text","content":"The following figure on the left shows the weight loss seen thus far for the different cohorts from the Phase 1 study that were treated for four weeks. There is a clear dose response starting from the 8mg dose through the 48 mg dose. The figure on the right compares the 4-week data to the 8-week data for the 48 mg cohort.","length":323,"tagName":"p"},{"type":"image","alt":"","displaySize":"","headline":null,"caption":"","className":"","disableSlideshowImg":false,"size":{"original":{"width":1672,"height":680,"url":"https://media.zenfs.com/en/scr.zacks.com/1171b359d64147785a147f51893098bf"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/ggctxXi.ajJLQrOmDaDEGA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTk2MDtoPTM5MDtjZj13ZWJw/https://media.zenfs.com/en/scr.zacks.com/1171b359d64147785a147f51893098bf","width":960,"height":390},"lightbox":{"url":"https://s.yimg.com/ny/api/res/1.2/5sDbySgODNbWz_FSY8Z8ag--/YXBwaWQ9aGlnaGxhbmRlcjt3PTI0MDA7aD05NzY7Y2Y9d2VicA--/https://media.zenfs.com/en/scr.zacks.com/1171b359d64147785a147f51893098bf","width":1200,"height":488}}},{"type":"text","content":"The following tables give the placebo adjusted results for body weight and waist circumference for the 48 mg cohort. One of the subjects in the placebo group reported implementing a “no carbohydrate” diet while participating in the study, which may have led to a substantial weight loss....

More updates from Metavia Inc.

waist circumferencePhase 1b trialglucagon receptorPhase 1bweight loss