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Xencor to Host Webcast to Discuss XmAb942 and XmAb412 Data Presentations at DDW
PASADENA, Calif., May 04, 2026--Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today reported final results from the Phase 1 study of XmAb942, a novel, potential best-in-class, long-acting anti-TL1A antibody for the treatment of inflammatory bowel disease (IBD). The results are being presented today at Digestive Disease Week® (DDW), being held in Chicago. Tomorrow, the company will also
About this update from Xencor, Inc.
-- Data support potentially best-in-class profile of XmAb942, under evaluation in ongoing global Phase 2b XENITH-UC study on track for 12-week induction results in 2027 -- -- Novel XenLock™ format optimizes bispecifics for treatment of autoimmune diseases; first XenLock™ candidate XmAb412 first-in-human healthy participant study on track for 3Q26 start -- -- Management to host webcast tomorrow, Tuesday, May 5, at 8:00 a.m. EDT -- PASADENA, Calif., May 04, 2026--(BUSINESS WIRE)--Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the treatment of cancer and autoimmune diseases, today reported final results from the Phase 1 study of XmAb942, a novel, potential best-in-class, long-acting anti-TL1A antibody for the treatment of inflammatory bowel disease (IBD). The results are being presented today at Digestive Disease Week® (DDW), being held in Chicago. Tomorrow, the company will also present the preclinical characterization of XmAb412 (TL1A x IL23p19) during the conference and will host a webcast at 8:00 a.m. EDT (5:00 a.m. PDT) on Tuesday, May 5, to discuss both presentations. Enrollment into the global Phase 2b XENITH-UC study of XmAb942 remains on track, with expectations that support a blinded interim analysis around year-end 2026 and the full results of the primary endpoint analysis during the second half of 2027. The study is enrolling approximately 220 patients across three active treatment arms and one placebo arm using asymmetric randomization, and the primary endpoint is clinical remission defined by the modified Mayo score at week 12. Enrollment into a first-in-human dose-escalation study of XmAb412, a novel first-in-class bispecific antibody targeting TL1A and IL23p19, is expected to begin during the third quarter of 2026. The first-in-human study in healthy participants is designed to characterize the pharmacokinetics and pharmacodynamics of XmAb412 and support further development for the treatment of patients with autoimmune and inflammatory diseases in 2027. "We are pleased to share clinical and preclinical data supporting the advancement of our TL1A franchise, which pairs our validated XmAb® engineering advantage with the promising therapeutic potential of TL1A. The Phase 1 results continue to reinforce XmAb942’s best-in-class drug exposure and convenient maintenance period dosing ...