Voyager’s Tau-Targeted Gene Therapy VY1706 for Alzheimer’s Disease to Be Featured in Developing Topics Poster Presentation at AAIC 2026

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LEXINGTON, Mass., June 29, 2026 (GLOBE NEWSWIRE) -- Voyager Therapeutics, Inc. (Nasdaq: VYGR), a biotechnology company dedicated to leveraging genetics to treat neurological diseases, today announced a Developing Topics (late-breaking) poster presentation at the upcoming Alzheimer's Association International Conference (AAIC) taking place in London, July 12-15, 2026. The Developing Topics poster presentation will feature VY1706, Voyager's investigational gene therapy targeting intracellular and extracellular tau for Alzheimer's disease (AD). Earlier this month, Voyager received U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for VY1706, enabling initiation of a clinical trial in adults with early AD, with dosing expected to begin in the second half of the year. Developing Topics: Drug DevelopmentIND-enabling GLP NHP study of VY1706, a BBB-crossing AAV gene therapy targeting tau in Alzheimer's (#Monday-1207). Rajeev Sivasankaran, SVP, Neuroscience, and Vik Arora, VP, Toxicology. Monday, July 13, 2026, 7:30 a.m. – 4:15 p.m. GMT The Developing Topics poster presentation will be available on Voyager's website at: https://www.voyagertherapeutics.com/science-publications. About VY1706VY1706 is an investigational gene therapy for Alzheimer's disease (AD) that targets tau, a protein associated with neurodegeneration and cognitive decline in AD. The core of VY1706 is a potent, vectorized siRNA that targets MAPT mRNA to decrease levels of both intracellular and extracellular tau in the brain. This core is encapsulated in a Voyager TRACER™ AAV capsid that leverages ALPL, a well-conserved, novel receptor identified by Voyager, to deliver the siRNA into the brain following a one-time, intravenous (IV) dose. The efficacy and safety of VY1706 have been assessed in a comprehensive preclinical program spanning multiple species. Three-month good laboratory practice (GLP) toxicology data for VY1706 demonstrated a favorable tolerability profile with no adverse clinical pathology or histopathological findings up to the highest dose tested (5E13 vg/kg) following a single IV dose in non-human primates (NHPs). VY1706 has also been demonstrated to reduce tau protein up to 75% in key NHP brain regions relevant to AD and to de-target the liver, a source of adverse events associated with other systemically administered gene therapies. Voyager is...

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