Voyager IV-Delivered CNS Gene Therapies Featured in Multiple Presentations at ASGCT 2026, Including Late Breaker on Tau-Targeted VY1706 for Alzheimer’s Disease

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- Late-breaking oral presentation: IV delivery of VY1706, a CNS penetrant AAV gene therapy for AD, demonstrates compelling pharmacology and safety in a 3-month GLP toxicology study in NHPs - - Additional data demonstrate continued capsid innovation via muscular and neuromuscular targeting, immune evasion, and manufacturability - LEXINGTON, Mass., April 27, 2026 (GLOBE NEWSWIRE) -- Voyager Therapeutics, Inc. (Nasdaq: VYGR), a biotechnology company dedicated to leveraging genetics to treat neurological diseases, today announced eight oral and poster presentations at the upcoming American Society of Gene & Cell Therapy’s (ASGCT) 2026 Annual Meeting taking place in Boston, May 11-15, 2026. Voyager’s investigational tau-silencing gene therapy VY1706 for Alzheimer’s disease, for which Voyager anticipates submitting an investigational new drug (IND) application in Q2 2026 to support projected first-in-human dosing in the second half of 2026, will be featured in a late-breaking presentation of three-month good laboratory practice (GLP) toxicology data. “As we prepare to advance our tau-silencing gene therapy VY1706 into the clinic for Alzheimer’s disease in the second half of the year, we are assembling a comprehensive preclinical data package that consistently demonstrates a compelling pharmacology and safety profile, and we look forward to sharing the latest data at ASGCT,” said Todd Carter, Ph.D., Chief Scientific Officer of Voyager Therapeutics. “Even as we prepare to advance the first gene therapy leveraging our novel, I.V.-delivered, brain-targeted TRACER capsids into the clinic, the team continues to raise the bar with new innovations to expand beyond the CNS via muscular and neuromuscular targeting and to expand the eligible patient population via immune evasion.” Late-Breaking Oral Presentation Intravenous delivery of VY1706, a CNS penetrant AAV gene therapy for Alzheimer’s disease, demonstrates compelling pharmacology and safety in a 3-month GLP toxicology study in NHPs. Todd Carter, Ph.D., Chief Scientific Officer. Wednesday, May 13, 2026, 8:00 a.m. – 9:45 a.m. ET Alzheimer’s Disease TargetsIntravenous delivery of a bi-functional AAV gene therapy to reduce endogenous ApoE4 and express ApoE2 in ApoE4 humanized mice (#1460). Michael Grannan, Ph.D., Director, Neuroscience. Tuesday, May 12, 2026, 5:00 p.m. – 6:30 p.m. ET Leveraging ...

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