Tenax Therapeutics Provides Update on TNX-102, TNX-103 and TNX-201 Clinical Programs

About this update from Tenax Therapeutics, Inc.

Receives a Notice of Allowance of Multiple Patent Claims for TNX-102 (subcutaneous levosimendan) Successfully Completes IV to Oral Transition Substudy for TNX-103 (oral levosimendan) Plans to Initiate Phase 3 Study of TNX-201 (oral imatinib mesylate) in Pulmonary Arterial Hypertension in 2H 2022 Forms Scientific Advisory Board with Expertise in Pulmonary Vascular Disease MORRISVILLE, N.C., Jan. 04, 2022 (GLOBE NEWSWIRE) -- Tenax Therapeutics, Inc. (Nasdaq: TENX), a specialty pharmaceutical company focused on identifying, developing, and commercializing products that address cardiovascular and pulmonary diseases with high unmet medical need, today provided patent and clinical program updates for its two lead product candidates, TNX-103 for the treatment of pulmonary hypertension associated with left heart failure (PH-HFpEF), and TNX-201 for the treatment of pulmonary arterial hypertension (PAH). TNX-102 Intellectual Property Update Tenax Therapeutics has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for the subcutaneous administration of levosimendan. The patent, expected to be issued in January 2022, will provide coverage of subcutaneous administration of levosimendan for the treatment of human subjects with health conditions of any kind, and expires at the end of 2039, exclusive of any patent term extension. The patent will be eligible for term extension. TNX-103 Program Update: Successful Completion of TNX-LVO-05 Substudy to Transition Patients from IV to Oral Levosimendan Tenax Therapeutics announced the completion of the transition from intravenous (IV) to oral levosimendan of those patients currently enrolled in the open label extension (OLE) rollover study (TNX-LVO-05), following their enrolment in the Phase 2 HELP trial. These patients with PH-HFpEF, having previously received weekly infusions of levosimendan for up to two years, were able to transition to oral levosimendan in this substudy, to continue treatment. The substudy was designed to determine the safety and tolerability of oral levosimendan in this population, with a goal of establishing an oral dose that would maintain its efficacy. All patients currently in the OLE study successfully completed the transition substudy without any unexpected safety issues or serious drug related adverse events. In addition, the multiple measures of efficacy of o...

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