Phathom Pharmaceuticals Completes Patient Enrollment Ahead of Schedule in Phase 2 pHalcon-EoE-201 Study of VOQUEZNA® (vonoprazan) in Eosinophilic Esophagitis (EoE)

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This trial is the first large, placebo-controlled clinical trial of an acid suppression treatment in EoETopline results for the double-blind 12-week treatment portion of the study are expected in Q4 of 2026 FLORHAM PARK, N.J., June 23, 2026 (GLOBE NEWSWIRE) -- Phathom Pharmaceuticals, Inc. (Nasdaq: PHAT), a biopharmaceutical company focused on developing and commercializing novel treatments for gastrointestinal (GI) diseases, today announced it has completed enrollment in its Phase 2 pHalcon-EoE-201 clinical trial evaluating VOQUEZNA® (vonoprazan) tablets as an investigational treatment for eosinophilic esophagitis (EoE) in adults. The study has enrolled 95 patients at 41 U.S. sites. Topline results are anticipated in the fourth quarter 2026. "The pHalcon-EoE-201 study reflects our commitment to advancing care for people living with GI diseases,” said Steve Basta, President and Chief Executive Officer at Phathom. “For many years, acid suppression with proton pump inhibitors (PPIs) has played an important role in the treatment of EoE. As the first large, placebo-controlled study of acid suppression therapy in EoE, the pHalcon-EoE-201 study is designed to evaluate whether vonoprazan may offer a new, oral, non-steroidal treatment option for patients with EoE and, if successful, could help inform our future development strategy in this growing indication.” "EoE remains a difficult disease to manage, with few approved therapies and a significant portion of patients relying on PPIs which are not FDA-approved for this indication," said Evan S. Dellon, MD, MPH, Professor of Medicine in the Division of Gastroenterology and Hepatology, and Director of the Center for Esophageal Diseases and Swallowing at the University of North Carolina School of Medicine, Chapel Hill, and principal investigator of the pHalcon-EoE-201 study. "Completing enrollment in this first large, placebo-controlled trial of an acid suppression treatment in EoE brings us closer to better understanding whether vonoprazan could offer a meaningful new option for patients." The pHalcon-EoE-201 study is a two-part, randomized, double-blind, placebo-controlled Phase 2 study. In Part 1, 95 adults with endoscopically confirmed EoE and dysphagia have been randomized evenly to receive VOQUEZNA 20 mg or placebo once daily for 12 weeks. Patients who complete Part 1 are eligible to enter Part 2, a 12-week ex...

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