Business
Operations Update
Physiomics plc has reported strong operational progress, building its largest commercial pipeline to date and identifying cost savings that will exceed exceptional general meeting expenses, primarily in the next financial year. The company has also completed IT infrastructure and operational systems assessments, confirming a scalable platform for growth and increased client demand. Management is focused on a robust financial strategy targeting a path towards breakeven, with revenues recognised and anticipated near-term commercial activity supporting a more sustainable business. Further details on progress, strategy, and future opportunities will be in the forthcoming annual report. Disclaimer*

About this update from Physiomics Plc
26 June 2026 Physiomics plc ("Physiomics" or the "Company") Operations update Physiomics plc (AIM: PYC), a leading mathematical modelling, data science and biostatistics company supporting the development of new therapeutics and personalised medicine solutions, is pleased is pleased to provide shareholders with an update on the Company's operational progress and strategic development. The Company continues to make strong operational progress as it executes on its strategic priorities and works to strengthen the foundations of the business for future growth. In particular Physiomics is building what is currently its largest commercial pipeline in its history, providing a strong platform for future growth and reinforcing confidence in its market position. The Board of Directors remain encouraged by the level of engagement across both existing and prospective clients and looks forward to updating the market on further contract wins and commercial developments in due course. Inevitably the Company incurred one-off costs ahead of the general meeting in April 2026 in which the former directors were dismissed from their roles. The current Board has been disappointed with both the level and nature of some of these costs but, more positively, has identified several cost savings, the aggregate effect of which will exceed the exceptional general meeting related expenses, albeit will predominantly be realised in the next financial year. The Board has also welcomed the supportive review of the business prepared by consultant Stewart Williams. The review highlighted a number of areas for development, and the Board believes that the majority of these actions have already been addressed by management. In response to the recommendations arising from the review, the Company has also undertaken a comprehensive assessment of its IT infrastructure and operational systems. This review has confirmed that the business is well positioned to support its growth ambitions and provides a scalable platform capable of onboarding and delivering both existing and larger, more complex client projects. The Board believes these enhancements further strengthen the Company's ability to meet increasing customer demand while maintaining the high standards of service expected by its clients. The Board would also like to acknowl...