MBX Biosciences Provides Obesity Portfolio Update Including Initial Phase 1 Data for MBX 4291 Supporting Potential for Once-Monthly Dosing

About this update from Mbx Biosciences, Inc.

Preliminary blinded data from ongoing Phase 1 trial demonstrated mean weight loss of 7% (range 0-16%) at 8 weeks in first MAD Part B cohort (n=8, including 2 placebo) MBX 4291 generally well tolerated, only one event of diarrhea, nausea or vomiting through 8 weeks in first MAD Part B cohort MBX 4291 12-week Phase 1 MAD Part C data remain on track for Q4 2026 MBX 5765 nominated as amycretin prodrug development candidate, a novel GLP-1 / GIP / glucagon / DACRA agonist designed for once-monthly dosing, superior efficacy and improved tolerability Imapextide Phase 2a STEADI™ trial results demonstrate positive proof of concept in post-bariatric hypoglycemia (PBH) Company to host in-person and virtual Obesity Day today at 10:30 a.m. ET CARMEL, Ind. and BURLINGTON, Mass., May 11, 2026 (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced multiple updates on its obesity portfolio. Preliminary blinded Phase 1 data for MBX 4291, a GLP-1/GIP co-agonist prodrug for obesity, demonstrate a pharmacokinetic profile supporting the potential for once-monthly dosing and competitive weight loss in the first multiple ascending dose (MAD) cohort. These results, along with additional pipeline updates, will be discussed at the Company’s Obesity Day presentation today at 10:30 a.m. ET. “We are proud to share preliminary blinded data from the ongoing Phase 1 clinical trial of our GLP-1/GIP co-agonist prodrug in obesity,” said Sam Azoulay, MD, Chief Medical Officer of MBX Biosciences. “The unique pharmacokinetic profile of MBX 4291 has the potential to support a self-titrating weekly induction regimen and the potential for true once-monthly dosing. Moreover, preliminary blinded data from the first MAD cohort following four weekly titration doses and a single once-monthly dose demonstrated gradual accumulation of active peptide, leading to competitive weight loss and tolerability after eight weeks. These results will inform the upcoming 12-week MAD portion of our Phase 1 trial, and we remain on track to share data from the MAD Part C in Q4.” “These initial MBX 4291 clinical data illustrate the potential of our PEP™ platform to create differentiated, long-acting and more to...

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