Kyverna Therapeutics Highlights Updated Miv-cel Data at EULAR Demonstrating Substantial Reduction in Disease Activity in ACPA-Positive, Treatment Refractory Rheumatoid Arthritis

About this update from Kyverna Therapeutics, Inc.

Majority of patients met the American College of Rheumatology improvement criteria (ACR70) response by Week 36 Single-dose of miv-cel delivered deep B-cell depletion with evidence of immune reset Miv-cel continues to demonstrate a well-tolerated safety profile, consistent with observations from over 100 patients treated to date1 Data reinforce miv-cel’s differentiated clinical profile and opportunity to change the treatment paradigm across a variety of autoimmune diseases EMERYVILLE, Calif., June 03, 2026 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a late-stage clinical biopharmaceutical company developing cell therapies for patients with autoimmune diseases, today announced the presentation of updated data from the Phase 1 portion of COMPARE, a Phase 1/2 investigator-initiated trial (IIT) evaluating miv-cel (mivocabtagene autoleucel, KYV-101) in patients with active anti-citrullinated protein antibody (ACPA)-positive, treatment-refractory rheumatoid arthritis (RA). The data will be presented today in an oral presentation by Charité - University of Berlin at the European Alliance of Associations for Rheumatology (EULAR) 2026 Congress in London. Building on the safety and efficacy results reported at ACR Convergence 2025, the updated data showed a single dose of miv-cel resulted in deep B-cell depletion with subsequent reconstitution with a naïve B-cell phenotype in ACPA-positive RA patients. These findings demonstrate the potential of an immune reset and translate into meaningful clinical improvement. “We’re very pleased to see this updated data add to the growing body of evidence underscoring miv-cel’s profound clinical activity across multiple autoimmune indications,” said Naji Gehchan, Chief Medical and Development Officer of Kyverna Therapeutics. “In this heavily pre-treated patient population with difficult-to-treat ACPA-positive rheumatoid arthritis, miv-cel demonstrated deep B-cell depletion and substantial reduction in disease activity and disease-associated autoantibodies, highlighting its promising potential to redefine how we treat this debilitating disease.” Charité – University of Berlin Oral Presentation The COMPARE trial is an open-label, randomized, controlled Phase 1/2 study evaluating miv-cel against the anti-CD20 monoclonal antibody rituximab in patients with active ACPA-positive, treatment-refractory RA with moderate...

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