Kymera Therapeutics Presents Phase 1 Data in Healthy Japanese Adults for KT-621, a First-in-Class Oral STAT6 Degrader, at the Japanese Dermatological Association Annual Meeting

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Oral presentation at JDA features new data from the KT-621 Phase 1 study in healthy Japanese adults, with safety and PK/PD results consistent with previously reported KT-621 clinical studies  KT-621 parallel Phase 2b trials, BROADEN2 in atopic dermatitis and BREADTH in asthma, ongoing with data expected by mid-2027 and late 2027, respectively WATERTOWN, Mass., June 12, 2026 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines for immunological diseases, today announced that the results from the Phase 1 study of KT-621, its first-in-class, oral STAT6 degrader, in healthy Japanese adults were shared in an oral presentation at the Japanese Dermatological Association (JDA) Annual Meeting being held June 11-14, 2026, in Kyoto, Japan. “The consistency we’ve demonstrated across KT-621 Phase 1 studies, from robust STAT6 degradation to a favorable safety profile, reflects the strong fidelity of translation of this unique approach from preclinical to clinical settings and further highlights KT-621’s compelling profile,” said Jared Gollob, MD, Chief Medical Officer of Kymera Therapeutics. “We believe KT-621 has the potential to transform care through a truly novel oral treatment option for patients living with chronic Type 2 inflammatory conditions, and the data reported to date continue to support its advancement globally across multiple diseases, starting with atopic dermatitis and asthma.” The Company has previously reported positive Phase 1 data for KT-621 in non-Japanese healthy volunteers and patients with moderate to severe atopic dermatitis. Across these studies, KT-621 demonstrated rapid, deep and sustained STAT6 degradation in blood and skin, robust reductions in disease-relevant Type 2 inflammatory biomarkers, meaningful improvements on clinical endpoints and patient-reported outcomes in atopic dermatitis as well as in comorbid asthma and allergic rhinitis, and a favorable safety profile. The Phase 1 trial in healthy Japanese adults was designed to provide the pharmacokinetic/pharmacodynamic (PK/PD) and safety data required by regulators prior to enrollment of patients in Japan in the global KT-621 Phase 2b studies. The randomized, double-blind, placebo-controlled Phase 1 study enrolled 24 healthy Japanese adults across two dose levels ...

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