Kymera Therapeutics Presents New Preclinical Lupus Data for KT-579, First-in-Class, Oral IRF5 Degrader, at EULAR and FOCIS Congresses

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KT-579 demonstrated consistent disease-modifying activity comparable or superior to approved and clinically active therapies in multiple preclinical lupus models  KT-579 Phase 1 healthy volunteer trial ongoing, with data expected in 2H26 WATERTOWN, Mass., June 08, 2026 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing a new class of oral small molecule degrader medicines for immunological diseases, today announced the presentation of new preclinical data for KT-579, its potent, selective, oral IRF5 degrader, demonstrating disease-modifying activity in lupus models. The findings show that by selectively targeting and degrading IRF5, KT-579 offers a novel oral approach for complex, heterogeneous autoimmune diseases driven by multiple validated inflammatory pathways, including Type I interferons, pro-inflammatory cytokines and autoantibody responses. These data were presented at the European Alliance of Associations for Rheumatology (EULAR) Annual Meeting held June 3-6, 2026, in London, UK, and will be presented at the Federation of Clinical Immunology Societies (FOCIS) Annual Meeting being held June 9-12, 2026, in San Francisco, CA. “Lupus remains a complex and heterogeneous autoimmune disease, with many patients continuing to experience inadequate disease control despite available therapies,” said Juliet Williams, PhD, Head of Research, Kymera Therapeutics. “The data presented at these key medical meetings reinforce KT-579’s potential as a novel oral approach to modulating multiple disease-driving pathways implicated in lupus, including Type I IFN, pro-inflammatory cytokine and B cell-driven responses. The consistent activity observed across patient-derived cells and multiple preclinical lupus models provides strong support for IRF5 degradation as a promising strategy to broadly address the underlying disease biology with a convenient oral medicine.” The Company previously reported data demonstrating KT-579’s compelling profile in preclinical studies using human primary cell systems, patient-derived cells and in vivo disease models of lupus, rheumatoid arthritis, and inflammatory bowel disease showing activity comparable or superior to existing standards of care. New data presented at EULAR and FOCIS further validate KT-579’s broad and consistent activity across preclinical models of lup...

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