Jaguar Health Announces Statistically Significant Results from Effectiveness Trial of Crofelemer (FDA Approved Canalevia-CA1) for Treatment of Chemotherapy-Induced Diarrhea in Dogs

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[{"type":"text","content":"Company Advances Towards Full FDA Approval of Crofelemer for Chemotherapy-Induced Diarrhea","length":90,"tagName":"p"},{"type":"text","content":"SAN FRANCISCO, CA / ACCESS Newswire / April 29, 2026 / Jaguar Health, Inc. (NASDAQ:JAGX) (Jaguar) today announced topline results from the completion of its effectiveness trial of crofelemer (FDA conditionally approved Canalevia-CA1) for the treatment of chemotherapy-induced diarrhea (CID) in dogs. The statistically significant results demonstrated that dogs suffering from CID that were treated with Canalevia-CA1 twice daily at the onset of diarrhea had, at the end of 3 days of treatment, an average daily stool that is regarded as normal. Moreover, an owner's survey at the end of the study reported that 83% of owners indicate that Canalevia-CA1 was an effective treatment for their dog's CID. Additionally, around 40% of dog owners reported that Canalevia-CA1 completely resolved their dog's CID. In comparison, only 12.5% of owners reported they saw an improvement in their dog's CID without the use of any chemotherapy-induced diarrhea treatments. The Company expects to file the data from the complete analysis of this trial in support of full regulatory approval of crofelemer for CID and also submit for scientific publication.","length":1156,"tagName":"p"},{"type":"text","content":""We are quite pleased with the study results, supporting the paradigm shifting antisecretory mechanism of action of crofelemer in CID, typically a chloride ion mediated secretory diarrhea common across all mammals. Our vision at the company is to expand the opportunity to treat a broader collection of symptomatic diarrhea causes in companion animals with an anti-secretory approach," said Lisa Conte, Jaguar Founder and CEO.","length":436,"tagName":"p"},{"type":"text","content":"This study, "Clinical Field Study to Collect Real-World Data (RWD) to Demonstrate Real-World Evidence (RWE) of Effectiveness for Canalevia®-CA1 (Crofelemer delayed-release tablets) 125 mg for the Treatment of Chemotherapy-Induced Diarrhea (CID) in Dogs" is the pivotal study in substantiating treatment effectiveness in the upcoming Animal Drug application.","length":367,"tagName":"p"},{"type":"text","content":"Important Safety Information About Canalevia®-CA1","length":49,"tagName":"p"},{"type":"text","con...

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