– Unprecedented CLEAR Outcomes Study Approaching 95% MACE Accumulation–
– U.S. Net Product Revenue of NEXLETOL® (bempedoic acid) Tablets and NEXLIZET® (bempedoic acid and ezetimibe) Tablets Grew approximately 109% Y/Y to $13.4 Million in the First Quarter 2022–
– Retail Prescription Equivalents Grew 56.7% Year over Year –
ANN ARBOR, Mich., May 03, 2022 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today reported financial results for the first quarter ended March 31, 2022 and provided a business update.
"During the first quarter of 2022, our team remained focused on our two primary objectives, delivering on our promise to drive consistent growth for NEXLETOL® and NEXLIZET®, available today, and advancing our unprecedented CLEAR Outcomes trial, which is approaching 95% MACE accumulation,” said Sheldon Koenig, president and chief executive officer of Esperion. “Looking ahead to what will be a significant year for Esperion, we continue to anticipate achieving 100% MACE accumulation during the second half of this year, with a topline readout in the first quarter of 2023. With cardiovascular disease persisting as the leading cause of death in the United States, and heart disease and stroke mortality rates rising sharply since the onset of the COVID-19 pandemic, these results remain of critical importance for millions of patients suffering from cardiovascular disease. CLEAR is the first and only outcomes study to focus predominantly on patients who are unable to achieve their LDL cholesterol goals with existing treatment options, with a particular focus on patient groups that are historically underrepresented in clinical trials. The results have the potential to demonstrate the significant role of bempedoic acid in the cardiovascular disease therapy landscape.”
2022 Key Accomplishments and Recent Highlights
- Approaching 95% MACE Accumulation in the CLEAR Outcomes Trial
- Partner Daiichi Sankyo continued European rollout of NILEMDO® and NUSTENDI® into UK and most recently Belgium, Switzerland and the Netherlands in the first quarter; at least 52,000 European patients now on therapy as of March 2022
- Announced appointment of Stephen Rocamboli to Esperion Board of Directors
- Announced support of collaborative pragmatic trial with an integrated and learning health care delivery system in northern California to study the effects of NEXLIZET (bempedoic acid and ezetimibe) in reducing LDL-cholesterol following a recent acute coronary syndrome event
- Announced key NEXLETOL data presentations at the American College of Cardiology’s 71st Annual Scientific Session & Expo. The findings from the pooled analyses of Phase 3 NEXLETOL data demonstrated that bempedoic acid can be utilized to significantly lower LDL-C in patients with conditions such as hypertension which are associated with increased cardiovascular risk, further expanding the understanding of NEXLETOL in high-risk and diverse patient populations.
- Announced key publications in peer-reviewed journals
- Pooled Phase 3 data demonstrating the efficacy and safety of bempedoic in patients not receiving statins were published in the Journal of Clinical Lipidology. The results highlighted that a cohort of patients taking bempedoic acid without statins observed statistically significant reductions (p