Healthcare
Dysport® is the first botulinum toxin to achieve positive topline Phase III results in both episodic and chronic migraine.
Dysport® achieved statistically significant topline Phase III results, meeting primary endpoints in both episodic (E-BEOND) and chronic (C-BEOND) migraineDysport is the first botulinum toxin in episodic migraine to demonstrate a statistically significant reduction in monthly migraine daysDysport was well-tolerated across both trials with safety consistent with the known profile PARIS, FRANCE – 9 JULY 2026 – Ipsen (Euronext: IPN; ADR: IPSEY) today announced positive topline results from its Phase
About this update from Ipsen Sa
PARIS, FRANCE – 9 JULY 2026 – Ipsen (Euronext: IPN; ADR: IPSEY) today announced positive topline results from its Phase III BEOND migraine program evaluating Dysport® (abobotulinumtoxinA) for the prevention of episodic (E-BEOND) and chronic migraine (C-BEOND) in adults. Both the E-BEOND and C-BEOND trials met their primary endpoints, a reduction in monthly migraine days versus placebo. The E-BEOND results represent the first Phase III trial in which a botulinum toxin has demonstrated statistically significant efficacy in episodic migraine. Together with the positive C-BEOND results, BEOND is the first Phase III clinical program to demonstrate efficacy of a botulinum toxin in the prevention of both episodic and chronic migraine. Dysport was well-tolerated. Safety findings observed across both trials were consistent with well-established use of Dysport in approved indications, with no new or unexpected signals identified. "These results represent a significant advance in the development of botulinum toxin therapies for migraine," said Christelle Huguet, PhD, EVP and Global Head of R&D. "BEOND is the first Phase III program to demonstrate efficacy of a botulinum toxin in both episodic and chronic migraine. Together, these findings position Dysport as a potential first-in-class treatment for a broad migraine population." Migraine remains a common neurological disorder with a high unmet medical need. Migraine can be severely debilitating for people living with the condition and may have life-long impacts, frequently disrupting their ability to work, to plan or enjoy a social life. Episodic migraine (defined in the E-BEOND trial as experiencing up to 14 headache days per month of which at least 6 were migraine days) is a substantially larger patient population than chronic migraine (defined as experiencing headaches on 15 or more days per month, with at least 8 migraine days). "These Phase III topline results position Dysport as the first botulinum toxin to demonstrate efficacy for both episodic and chronic migraine prevention, supporting an advance in treatment options for patients," said Dr. Cristina Tassorelli, MD, Professor and Chair of Neurology and Director of the Department of Brain and Behavioral Sciences at the University of Pavia, based in Pavia, Italy and Principal Investigator for the C-BEOND trial.