Botanix Pharmaceuticals Limited · ASX:BOT

Botanix Pharmaceuticals — Investor Presentation (July 2016)

17 slides from Botanix Pharmaceuticals's investor presentation, Jul 20, 2016

  1. Slide 1: Restoring healthy skin

    + For personal use only restoring healthy skin ASX:BOT www.botanixpharma.com

  2. Slide 2: Notice

    + Notice For personal use only 2 This presenta,on prepared by Botanix Pharmaceu,cals Limited ("Company") does not cons,tute, or form part of, an offer to sell or the solicita,on of an offer to subscribe for or buy any securi,es, nor the solicita,on of any vote or approval in any jurisdic,on, nor shall

  3. Slide 3: Botanix Pharmaceuticals

    + Botanix Pharmaceuticals For personal use only 3 n US based medical dermatology company n Focused on new treatments for acne, psoriasis, and atopic dermatitis Drug active: n Utilising a synthetic form of cannabidiol as – synthetic cannabidiol the drug active, which is pharmaceutical grade and co

  4. Slide 4: Corporate Overview

    +Corporate Overview For personal use only * 4 Directors & management own ≈ 23% of the new Company Corporate* Team* ASX BOT Chairman Graham Griffiths • Nearmap • Pointerra Offer Price $0.020 • iintegrate Cash raised under the $3,500,000 Exec Director Matt Callahan • iCeutica Offer • Churchill Pharma

  5. Slide 5: Market opportunity … medical dermatology

    + Market opportunity … medical 5 dermatology For personal use only Particularly attractive segment of the pharma industry: n numerous unmet patient needs n many drugs with significant side effects n pipeline of new products is very thin, despite multi- billion dollar markets n development of der

  6. Slide 6: BTX1503 for acne – market opportunity

    + BTX1503 for acne – market 6 opportunity For personal use only $ 3 billion 50 million 0 $ value of annual spend on # of acne sufferers in the # of new actives for acne medicines for acne in US US approved since 2005 5.4 billion Confidential Property of Botanix Pharma

  7. Slide 7: How does acne happen?

    + How does acne happen? For personal use only 7 Acne develops when hair follicles become partially plugged with excess oils (sebum) and dead skin cells to form non-inflammatory and/or inflammatory lesions of varying grades of severity 1. Excess Production of 4. Inflammation sebum (puberty, stress, d

  8. Slide 8: BTX1503 – novel mechanism of action in acne

    + BTX1503 – novel mechanism of 8 action in acne For personal use only Switches off excessive oil production Reduces inflammation Blocks cell proliferation Reduces infection BTX1503 also targeting a benign side effect profile

  9. Slide 9: Permetrex™ - superior skin delivery

    + Permetrex™ - superior skin 9 delivery For personal use only Oral delivery of cannabidiol is only 6% bioavailable Unmodified Drug With Permetrex™ Epidermis Dermis Confidential Property of Botanix Pharma

  10. Slide 10: BTX1503 - planned positioning versus existing acne products

    + BTX1503 - planned positioning versus existing acne products For personal use only 10 Reduces Sebum ✓ ✗ ✗ ✗ ✗ ✗ ✓ Anti-inflammatory ✓ ✗ ✓ ✓ ✗ ✗ ✓ Anti-microbial ✓ ✓ ✗ ✗ ✓ ✓ ✓ Topical ✓ ✗ ✓ ✓ ✗ ✗ ✗ Minimal side effects ✓ ✗ ✓ ✓ ✗ ✓ ✗ “…the ‘Holy Grail’ of acne treatments would be a topical that can i

  11. Slide 11: BTX 1503 - planned timeline

    + BTX 1503 - planned timeline For personal use only 11 Accelerated development timetable when compared to oral and injectable drugs 2016 2017 2018 GMP Manufacturing Clinical Material GMP Testing and Release Phase 1 Safety Studies Phase 1b Acne Pilot Study Phase 2 Manufacturing / Scale Up Phase 2 Acn

  12. Slide 12: Targeted news flow and milestones for first months

    + Targeted news flow and milestones 12 for first 12 months For personal use only ✓ n Appointment experienced industry leaders for clinical and manufacturing positions n Formalisation world class Scientific Advisory Board n Completion GMP Manufacturing and testing n Filing TGA, DEA and/or Customs

  13. Slide 13: Pipeline - BTX 1308 for plaque psoriasis

    + Pipeline psoriasis - BTX 1308 for plaque For personal use only 13 • Immune mediated disease evidenced by raised red skin, covered with white scales Disease • Painful and embarrassing for patients Overview • Biologic drugs are expensive and have serious side effect issues (including lymphoma) • Abo

  14. Slide 14: Pipeline - BTX 1204 for atopic dermatitis

    + Pipeline - BTX 1204 for atopic dermatitis For personal use only 14 • Inflammatory disease (also called severe eczema) • Characterized by loss of barrier Disease function and skin inflammation Overview • Skin loses its ability to repair itself which activates a chronic immune response • US patient

  15. Slide 15: Team with significant FDA success…

    + Team with significant FDA success… For personal use only 15 Matt Callahan Dr Bill Bosch Mr Mark Davis Mr Steve Newhard Director Director Clinical/Regulatory Manufacturing/Quality • 3 FDA approved • 6 FDA approved • Unique experience • 35 years products products with cannabdiol manufacturing • IP a

  16. Slide 16: …and unique experience

    + …and unique experience For personal use only 16 Dr Gene Cooper Dr Joel Gelfand Prof James Leyden Prof Diane Thiboutot Consultant Medical Director Scientific Advisor Scientific Adviser Clinical Studies • 5 FDA approved • Emeritus Professor • Professor of products • Dermatology A/ Dermatology at Der

  17. Slide 17: Botanix …a compelling investment case

    + 17 Botanix …a compelling investment case For personal use only ü Significant unmet patient needs in acne, psoriasis, and atopic dermatitis ü Novel treatment for acne with a growing evidence base ü Proprietary drug delivery system ü Fast and efficient development pathway, relative to usual phar

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