Alzamend Neuro, Inc. · NASDAQ:ALZN
Alzamend Neuro — Investor Presentation (April 2022)
24 slides from Alzamend Neuro's investor presentation, Apr 18, 2022
Slide 1: Alzamend Neuro, Inc. Corporate Presentation April 2022
Alzamend Neuro, Inc. Corporate Presentation April 2022
Slide 2: Safe Harbor Statement
SAFE HARBOR STATEMENT 2 This presentation and other written or oral statements made from time to time by representatives of Alzamend Neuro, Inc . (the “Company” or “ Alzamend ”) contain “forward looking statements” within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Se
Slide 3: Table of Contents
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. TABLE OF CONTENTS 3 Introduction Company Overview 4 - 5 Overview of Alzheimer’s Disease Alzheimer’s Disease 6 Economic Burden 7 Therapeutic Landscape 8 Our Science General Scientific Overview 9 - 10 A
Slide 4: Company Overview
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Company Overview INTRODUCTION NASDAQ: ALZN 4 Industry Biotechnology Sector Small Molecule / Cell Therapy Founded 2016 IPO June 15, 2021 Last Reported Cash $11.8 Million (as of January 31, 2022 per 10
Slide 5: Company Overview: History and Current Projects
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Company Overview INTRODUCTION Company History Current Projects 5 AL001 (aka LISPRO): • an ionic cocrystal of lithium for the treatment of Alzheimer’s Disease and other neurodegenerative diseases and p
Slide 6: Alzheimer's Disease
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Alzheimer’s Disease OVERVIEW OF ALZHEIMER’S DISEASE 6 Alzheimer’s Disease: Alzheimer’s Disease is an irreversible, progressive brain disorder that slowly destroys memory and cognitive skills , and eve
Slide 7: Economic Burden
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Important Implications Economic Burden 1. In 2022, the estimated healthcare costs for treating individuals with Alzheimer’s Disease in the United States will be $321 billion , including $206 billion i
Slide 8: Therapeutic Landscape
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Therapeutic Landscape 8 OVERVIEW OF ALZHEIMER’S DISEASE https://alz - journals.onlinelibrary.wiley.com/pb - assets/DADM/TRCI%20Drug%20Pipeline%20Infographic - DoctorAudience - 2021%20 - %20No%20 AA%20
Slide 9: Pipeline
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Pipeline GENERAL SCIENTIFIC OVERVIEW 9 Product Candidate Indication Pre - Clinical Phase I Phase II Phase III FDA Approval AL001 • Alzheimer’s Disease • Bipolar Disorder • Major Depressive Disorder (D
Slide 10: Overview of Our Science
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of Our Science GENERAL SCIENTIFIC OVERVIEW 10 Therapeutic Drug Synopsis Strength Status AL001 ▪ Use of patented Ionic Cocrystal (ICC) technology delivering a therapeutic combination of Lithiu
Slide 11: AL001 Phase I Trial
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. AL001 Phase I Trial 11 Study No. Study Title Description Status AL001 - ALZ01 (US) A randomized, balanced, Phase I, single - dose, open - label, two - treatment, two - period, two sequence, crossover,
Slide 12: Select Results from Phase I Trial
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Safety/Tolerability: Primary Endpoint Met Select Results from Phase I Trial 12 » AL001 was shown to be safe and well - tolerated in healthy adult subjects » No serious adverse events and no deaths wer
Slide 13: AL001 (aka LISPRO)
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. AL001 (aka LISPRO ) 13 • AL001 is a patented ionic cocrystal technology delivering a therapeutic combination of lithium , proline and salicylate • AL001 exhibits improved non - clinical pharmacokineti
Slide 14: AL001 (aka LISPRO) Preclinical Results
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. AL001 (aka LISPRO) 14 The results of our preclinical studies, conducted from May 2016 to June 2017 , are summarized below : • AL 001 had no effect on renal COX 2 activity ( Tg - Ctrl vs . AL 001 : p >
Slide 15: AL001 (aka LISPRO) Preclinical Studies
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. AL001 (aka LISPRO) 15 • Our pre - clinical studies encompassed the treatment of 28 transgenic (or genetically modified) and 10 non - transgenic mice with lithium carbonate and AL001. • Female APPSWE/P
Slide 16: Overview of AL002 (aka E22W)
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of AL002 (aka E22W) 16 • Our goal is to develop an Alzheimer’s Abeta vaccine candidate that will be devoid of the problems associated with current vaccine therapies. Our studies concluded the
Slide 17: Overview of AL002 (aka E22W)
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of AL002 (aka E22W) 17 • We illustrated our result by using Abeta peptide pulsed Dendritic Cells (“DC”) as a vaccine in Tg APP/PS1 mice. • ABeta 1 - 42 with different mutation were synthesize
Slide 18: Overview of Alzamend Neuro's Intellectual Property (Licensed Patents)
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of Alzamend Neuro’s Intellectual Property (Licensed Patents) ALZAMEND NEURO 18 Title of Patent Patent Type Therapeutic Drug Date Filed Date Issued Expiration Date Patent # Lithium Cocrystals
Slide 19: Overview of Alzheimer's Disease Drugs on the Market
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of Alzheimer’s Disease Drugs on the Market COMPETITIVE LANDSCAPE 19 Aricept Exelon Namenda Razadyne *Aricept – Eisai Co., Ltd., Financial Results for Fiscal 2020(3/31/2021 for JPY FX) ( https
Slide 20: Overview of Market Opportunity for AL001 and AL002
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Overview of Market Opportunity for AL001 and AL002 COMPETITIVE LANDSCAPE 20 Patient Population United States Global (Including US) Major Depressive Disorder(MDD) 21 Million¹ 280 Million² PTSD 9 Millio
Slide 21: Alzamend Leadership Team
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Alzamend Leadership Team ALZAMEND NEURO 21 Stephan Jackman Chief Executive Officer and Director 20+ years multi - industry experience, specialized in Biotech and Pharmaceutical Lien T. Escalona Chief
Slide 22: Alzamend Scientific Advisory Board
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Alzamend Scientific Advisory Board ALZAMEND NEURO 22 Thomas M. Wisniewski, MD Director, NYU Langone’s Pearl I. Barlow Center for Memory Evaluation and Treatment 300+ Peer - Reviewed Medical Journal Pu
Slide 23: Alzamend Board of Directors
Alzamend Neuro, Inc. information cannot be disclosed or reprinted without prior written permission. Lynne Fahey McGrath, Ph.D. Regulatory Affairs and Product Development Consultant 30+ years experience, Biotech and Pharmaceuticals M.P.H./Ph.D., Public Health from UMDNJ – Robert Wood Johnson Medical
Slide 24: Contact Us
CONTACT US 3500 Lenox Road, Suite 1500 Atlanta, GA 30326 +1 (844) 722 - 6333 Info@alzamend.com www.alzamend.com April 2022