Roche Holding Ltd · SIX:RO

Roche — Discovery Virtual Slide Box

52 slides from Roche's investor presentation, 2018

1. Slide 1: Discovery Ultra Accelerate Your Success

   Discovery Ultra Accelerate Your Success 1 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

2. Slide 2: Usage rules for this slide deck

   The following slide deck is provided to you per your request for a more functional, customizable tool for use in customer presentations. This material has been approved as is, however, slides may be removed, hidden or rearranged from either within this deck or another approved “mix and match” deck f

3. Slide 3: 2-plex chromogenic

   2-plex chromogenic Tissue: Norma l Tonsil Markers & Detections: CD8 wi th DISCOVERY Teal HRP ki t CD4 wi th DISCOVERY Purple kit 3 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

4. Slide 4: 2-plex chromogenic

   2-plex chromogenic Tissue: Brea st Ca rcinoma Markers & Detections: HER2/neu (4B5) with ChromoMap DAB Kit p53 (DO-7) wi th DISCOVERY Purple Ki t 4 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

5. Slide 5: 2-plex chromogenic

   2-plex chromogenic Tissue: Skin Markers & Detections: Ma rt-1 wi th DISCOVERY Yellow kit HMB45 wi th DISCOVERY Teal HRP kit 5 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

6. Slide 6: 2-plex chromogenic

   2-plex chromogenic Tissue: Lung Carcinoma Markers & Detections: PD-L1 wi th DISCOVERY Purple kit CD8 wi th DISCOVERY Yellow kit 6 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

7. Slide 7: 2-plex chromogenic

   2-plex chromogenic Tissue: Brain Markers & Detections: Al phaSyn with DISCOVERY Silver kit PGP9.5 wi th DISCOVERY Yellow kit 7 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

8. Slide 8: 2-plex fluorescence

   2-plex fluorescence Tissue: Placenta Markers & Detections: CONFIRM Vi mentin (V9) with DISCOVERY Rhodamine Ki t Smooth Muscle Actin (1A4) with DISCOVERY FITC Ki t 8 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

9. Slide 9: 3-plex chromogenic

   3-plex chromogenic Tissue: Lung Carcinoma Markers & Detections: CONFIRM Ki -67 (30-9) with ChromoMap DAB Detection Kit Cytokera tin 19 (A53-B/A2.26) with DISCOVERY Yel low Detection Kit E-ca dherin with DISCOVERY Purple Detection Ki t 9 © 2018 Roche DISCOVERY Products are for research use only. Not

10. Slide 10: 3-plex chromogenic

    3-plex chromogenic Tissue: Skin Markers & Detections: Mart-1 wi th DISCOVERY Purple Kit HMB45 with DISCOVERY Yellow Kit Ki-67 with DISCOVERY Teal HRP Kit 10 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

11. Slide 11: 3-plex chromogenic

    3-plex chromogenic Tissue: Normal Tonsil Markers & Detections: CD3 (2GV6) with DISCOVERY Purple Kit CD8 (SP57) with DISCOVERY Yellow Kit CD4 (SP35) with DISCOVERY Teal HRP Kit 11 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

12. Slide 12: 3-plex chromogenic

    3-plex chromogenic Tissue: Hodgkin Lymphoma Markers & Detections: CD20 (L26) with DISCOVERY Purple Kit CD15 (MMA) with DISCOVERY Yellow Kit CD30 (Ber-H2) with DISCOVERY Teal HRP Kit 12 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

13. Slide 13: 3-plex chromogenic

    3-plex chromogenic Tissue: Lung Carcinoma Markers & Detections: PD-L1 with DISCOVERY Purple kit CD8 with ChromoMap DAB kit TTF1 with DISCOVERY Teal HRP kit 13 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

14. Slide 14: 3-plex chromogenic

    3-plex chromogenic Tissue: Kidney Markers & Detections: SMA with DISCOVERY Purple kit CD34 with DISCOVERY Yellow kit S100 with DISCOVERY Teal HRP kit 14 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

15. Slide 15: 3-plex fluorescent

    3-plex fluorescent Tissue: Normal Tonsil Markers & Detections: FOXP3 wi th DISCOVERY FAM Ki t CD68 wi th DISCOVERY Cy5 Ki t CD8 wi th DISCOVERY Red 610 Ki t 15 © 2018 Roche DISCOVERY Products are for Research Use Only. Not for use in diagnostic procedures.

16. Slide 16: 4-plex chromogenic

    4-plex chromogenic Tissue: Breast Carcinoma Markers & Detections: HER2 with DISCOVERY ChromoMap DAB Kit Ki-67 with DISCOVERY Yellow Kit ER with DISCOVERY Purple Kit PR with DISCOVERY Teal HRP Kit Ki-67 + PR co-localization Ki-67 + ER co-localization 16 © 2018 Roche DISCOVERY Products are for researc

17. Slide 17: 4-plex chromogenic

    4-plex chromogenic Tissue: Non-small cell lung cancer Markers & Detections: PD-L1 (SP263) with DISCOVERY Purple kit CD68 (KP-1) with DISCOVERY Teal HRP kit CD8 (SP57) with ChromoMap DAB kit Pan Keratin with DISCOVERY Yellow kit 17 © 2018 Roche DISCOVERY Products are for research use only. Not for us

18. Slide 18: 4-plex chromogenic

    4-plex chromogenic Tissue: Breast Carcinoma Markers & Detections: Ki-67 (30-9) with DISCOVERY Purple kit ER (SP1) with DISCOVERY Teal HRP kit HER2 (4B5) with ChromoMap DAB kit Pan Keratin with DISCOVERY Yellow kit Breast HER2 3+ Breast HER2 0 18 © 2018 Roche DISCOVERY Products are for research use o

19. Slide 19: 4-plex chromogenic

    4-plex chromogenic Tissue: Normal Tonsil Markers & Detections: PD-L1 with DISCOVERY Purple kit CD8 with DISCOVERY Teal HRP kit Ki-67 with DISCOVERY Green HRP kit CD20 with DISCOVERY Yellow kit 19 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

20. Slide 20: 4-plex chromogenic

    4-plex chromogenic Tissue: Prostate Carcinoma Markers & Detections: BCC (basal cell cocktail) with ChromoMap DAB kit Ki-67 with DISCOVERY Purple kit p504s with DISCOVERY Teal HRP kit ERG with DISCOVERY Yellow kit 20 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic

21. Slide 21: 4-plex fluorescent

    4-plex fluorescent Tissue: Normal Tonsil Markers & Detections: FOXP3 with DISCOVERY FAM Kit CD68 with DISCOVERY Cy5 Kit CD8 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit 21 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

22. Slide 22: 4-plex fluorescent

    4-plex fluorescent Tissue: Skin Melanoma Markers & Detections: Mart-1 with DISCOVERY Rhodamine 6G Kit Vimentin (V9) with DISCOVERY Cy5 Kit Ki-67 (30-9) with DISCOVERY FAM Kit SOX10 (SP267) with DISCOVERY DCC Kit 22 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic

23. Slide 23: 5-plex chromogenic

    5-plex chromogenic Tissue: Normal Tonsil Markers & Detections: CD4 with DISCOVERY Purple kit CD8 with DISCOVERY Teal HRP kit Ki-67 with DISCOVERY Green kit CD68 with DISCOVERY Yellow kit Pan Keratin with DISCOVERY Silver kit 23 © 2018 Roche DISCOVERY Products are for research use only. Not for use i

24. Slide 24: 5-plex chromogenic

    5-plex chromogenic Tissue: Skin Markers & Detections: CD3 (2GV6) with DISCOVERY Purple kit Tryptase with DISCOVERY Teal HRP kit Vimentin (V9) with DISCOVERY Silver kit Ki-67 (30-9) with DISCOVERY Green kit CK14 (SP53) with DISCOVERY Yellow kit 24 © 2018 Roche DISCOVERY Products are for research use

25. Slide 25: 5-plex chromogenic

    5-plex chromogenic Tissue: Lymph Node Markers & Detections: CD3 (2GV6) with DISCOVERY Purple kit CD4 (SP35) with DISCOVERY Teal HRP kit CD30 (Ber-H2) with DISCOVERY Silver kit CD20 (L26) with ChromoMap DAB kit CK8 (SP57) with DISCOVERY Yellow kit 25 © 2018 Roche DISCOVERY Products are for research u

26. Slide 26: 5-plex chromogenic

    5-plex chromogenic Tissue: Lung Carcinoma Markers & Detections: CD8 (SP57) with DISCOVERY Purple kit PD-L1 (SP263) with DISCOVERY Teal HRP kit CD68 (KP1) with DISCOVERY Silver kit CD20 (L26) with ChromoMap DAB kit Pan Keratin with DISCOVERY Yellow HRP kit 26 © 2018 Roche DISCOVERY Products are for r

27. Slide 27: 5-plex chromogenic

    5-plex chromogenic Tissue: Lung Carcinoma Markers & Detections: CD4 (SP35) with DISCOVERY Purple kit CD8 (SP57) with DISCOVERY Teal HRP kit CD68 (KP1) with DISCOVERY Silver kit CD20 (L26) with ChromoMap DAB kit Pan Keratin with DISCOVERY Yellow kit 27 © 2018 Roche DISCOVERY Products are for research

28. Slide 28: 5-plex fluorescent

    5-plex fluorescent Tissue: Normal Tonsil Markers & Detections: FOXP3 with DISCOVERY FAM Kit CD68 with DISCOVERY Cy5 Kit CD8 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit CD20 with DISCOVERY Rhodamine 6G 28 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic p

29. Slide 29: 5-plex fluorescent

    5-plex fluorescent Tissue: Lung Carcinoma Markers & Detections: FOXP3 with DISCOVERY FAM Kit CD68 with DISCOVERY Cy5 Kit CD8 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit CD20 with DISCOVERY Rhodamine 6G 29 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic

30. Slide 30: 5-plex fluorescent

    5-plex fluorescent Tissue: Ovarian Carcinoma Markers & Detections: FOXP3 with DISCOVERY FAM Kit CD68 with DISCOVERY Cy5 Kit CD8 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit CD20 with DISCOVERY Rhodamine 6G 30 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnost

31. Slide 31: 5-plex fluorescent

    5-plex fluorescent Tissue: Peyer’s Patch Markers & Detections: FOXP3 with DISCOVERY FAM Kit CD68 with DISCOVERY Cy5 Kit CD8 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit CD20 with DISCOVERY Rhodamine 6G 31 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic p

32. Slide 32: 5-plex fluorescent

    5-plex fluorescent Tissue: Normal Tonsil Markers & Detections: CD68 with DISCOVERY FAM Kit CD34 with DISCOVERY Cy5 Kit CD3 with DISCOVERY Red 610 Kit CD4 with DISCOVERY DCC Kit CD8 with DISCOVERY Rhodamine 6G 32 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic pro

33. Slide 33: 5-plex fluorescent

    5-plex fluorescent Tissue: Non-small cell lung cancer Markers & Detections: Pan Keratin with DISCOVERY FAM Kit PD-L1 (SP263) with DISCOVERY Cy5 Kit CD68 with DISCOVERY Red 610 Kit CD4 with DISCOVERY DCC Kit CD8 with DISCOVERY Rhodamine 6G 33 © 2018 Roche DISCOVERY Products are for research use only.

34. Slide 34: 5-plex fluorescent

    5-plex fluorescent Tissue: Squamous Cell Carcinoma Markers & Detections: PD-L1 (SP263) with DISCOVERY FAM Kit FoxP3 with DISCOVERY Cy5 Kit CD68 with DISCOVERY Red 610 Kit CD3 with DISCOVERY DCC Kit CD8 with DISCOVERY Rhodamine 6G 34 © 2018 Roche DISCOVERY Products are for research use only. Not for

35. Slide 35: 5-plex fluorescent

    5-plex fluorescent Tissue: Mantle Cell Lymphoma Markers & Detections: CD20 with DISCOVERY FAM Kit Ki-67 with DISCOVERY Cy5 Kit Cyclin D1 with DISCOVERY Red 610 Kit CD5 with DISCOVERY DCC Kit Bcl2 with DISCOVERY Rhodamine 6G 35 © 2018 Roche DISCOVERY Products are for research use only. Not for use in

36. Slide 36: 6-plex chromogenic

    6-plex chromogenic Tissue: Lymph Node Markers & Detections: CD3 with DISCOVERY Purple kit CD4 with DISCOVERY Teal HRP kit CD68 with DISCOVERY Silver kit CD20 with ChromoMap DAB kit CD8 with DISCOVERY Yellow kit Ki-67 with DISCOVERY Green HRP kit 36 © 2018 Roche DISCOVERY Products are for research us

37. Slide 37: 2-plex fluorescence DNA ISH

    2-plex fluorescence DNA ISH Tissue: Normal Tonsil Markers & Detections: ROS 3’ (tel o) DNP Probe with DISCOVERY FITC Ki t ROS 5’ (cent) DIG Probe with DISCOVERY Rhodamine Ki t 37 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

38. Slide 38: Chromogenic DNA ISH + IHC

    Chromogenic DNA ISH + IHC Tissue: Breast Carcinoma Markers & Detections: HER2 DNA wi th DISCOVERY Silver kit HER2 protein with ChromoMap DAB kit Chromos ome 17 with ChromoMap Red kit 38 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

39. Slide 39: Chromogenic DNA ISH + IHC

    Chromogenic DNA ISH + IHC Tissue: Breast Carcinoma Markers & Detections: HER2 DNA wi th DISCOVERY Silver kit HER2 protein with DISCOVERY Purple kit Chromos ome 17 with DISCOVERY Yellow kit 39 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

40. Slide 40: Chromogenic mRNA ISH + IHC

    Chromogenic mRNA ISH + IHC Tissue: Normal Tonsil Markers & Detections: E-Ca dherin mRNA with DISCOVERY mRNA DAB Ki t E-Ca dherin protein with DISCOVERY Purple Kit Pa n-Keratin protein with DISCOVERY Teal HRP Kit 40 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic

41. Slide 41: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Brain Markers & Detections: MnNmda r1C1 with DISCOVERY mRNA DAB Kit MmAmpa 1C2 wi th DISCOVERY mRNA Red Ki t 41 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

42. Slide 42: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Liver Markers & Detections: PPIB wi th DISCOVERY mRNA Red Ki t POLR2A wi th DISCOVERY mRNA Teal HRP Ki t 42 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

43. Slide 43: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Ovary Markers & Detections: PPIB wi th DISCOVERY mRNA Red Ki t POLR2A wi th DISCOVERY mRNA Teal HRP Ki t 43 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

44. Slide 44: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Brain Markers & Detections: Sl c17a 7 with DISCOVERY mRNA Purple HRP Ki t Ga d1 with DISCOVERY mRNA DAB Kit 44 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

45. Slide 45: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Brain Markers & Detections: CNR1 wi th DISCOVERY mRNA Purple HRP Ki t Ga d1 with DISCOVERY mRNA Teal HRP Ki t 45 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

46. Slide 46: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Colon Markers & Detections: IgL wi th DISCOVERY mRNA Red Kit IgK wi th DISCOVERY mRNA Teal HRP Ki t 46 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

47. Slide 47: 2-plex chromogenic mRNA ISH

    2-plex chromogenic mRNA ISH Tissue: Kidney Markers & Detections: IgL wi th DISCOVERY mRNA Red Kit IgK wi th DISCOVERY mRNA Teal HRP Ki t 47 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

48. Slide 48: Chromogenic Dual mRNA ISH + IHC

    Chromogenic Dual mRNA ISH + IHC Tissue: Colon Markers & Detections: TNFSF9 wi th DISCOVERY mRNA Red Ki t CD274 wi th DISCOVERY mRNA Teal HRP Ki t CD8 wi th DISCOVERY Yellow Kit 48 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

49. Slide 49: Chromogenic Dual mRNA ISH + IHC

    Chromogenic Dual mRNA ISH + IHC Tissue: Liver Markers & Detections: TNFSF9 wi th DISCOVERY mRNA Red Ki t CD274 wi th DISCOVERY mRNA Teal HRP Ki t CD8 wi th DISCOVERY Yellow Kit 49 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

50. Slide 50: Chromogenic Dual mRNA ISH + IHC

    Chromogenic Dual mRNA ISH + IHC Tissue: Ovary Markers & Detections: TNFSF9 wi th DISCOVERY mRNA Red Ki t CD274 wi th DISCOVERY mRNA Teal HRP Ki t CD8 wi th DISCOVERY Yellow Kit 50 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

51. Slide 51: Chromogenic Dual mRNA ISH + IHC

    Chromogenic Dual mRNA ISH + IHC Tissue: Tonsil Markers & Detections: TNFSF9 wi th DISCOVERY mRNA Red Ki t CD274 wi th DISCOVERY mRNA Teal HRP Ki t CD8 wi th DISCOVERY Yellow Kit 51 © 2018 Roche DISCOVERY Products are for research use only. Not for use in diagnostic procedures.

52. Slide 52: Doing now what patients need next

    Doing now what patients need next 52 © 2018 Roche

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