Simulations Plus, Inc. · NASDAQ:SLP
Simulations Plus — Technical Presentation (October 2020)
15 slides from Simulations Plus's technical presentation, October 2020
Slide 1: DSX Webinar
*DILIsym®, NAFLDsym®, MITOsym®, GastroPlus®, ADMET Predictor® and SimPops® are registered trademarks, and SimCohorts™, IPFsym™, RADAsym™ and RENAsym™ are trademarks, of DILIsym Services Inc. and/or Simulations Plus Inc. for computer modeling software and for consulting services. CONFIDENTIAL CONFIDE
Slide 2: At SimulationsPlus We Put It All Together
At SimulationsPlus We Put It All Together Science Lead Business Pharmacology • Seamless collaboration Selection • Resources available to get • Integrated, innovative the job done on time solutions to meet your needs • One-stop shopping – single vendor for all of your in silico ADMET DMPK Treatment R
Slide 3: Our solutions inform the entire drug development process
Our solutions inform the entire drug development process Post Discovery Preclinical Phase 1 Phase 2 Phase 3 NDA Approval Pre- Approval IND EOP2 NDA Cheminformatics PBPK QSP/QST Dilisym Services Pharmacometrics Cognigen | Lixoft Regulatory Interaction NASDAQ: SLP 3
Slide 4: DSX Webinar Team
DSX Webinar Team Paul B. Watkins DILI-sim Initiative Founder and Shawn O’Connor Scientific Advisory Board Chair Scott Q Siler Brett Howell CEO, Simulations Plus Inc. RTP, NC Chief Scientific Officer President Lancaster, CA Bay Area, CA RTP, NC Lisl Shoda Principal Scientist Sergey Ermakov Grant Gene
Slide 5: QST Predicts Tox via Exposure, Mechanisms, and Inter-Patient Variability
QST Predicts Tox via the Intersection Between Exposure, Mechanisms, and Inter-Patient Variability Tox Exposure Mechanisms Tox Relevant Biochemistry CONFIDENTIAL 5
Slide 6: DILIsym Overview
DILIsym Overview • Multiple species: human, rat, mouse, and dog - Population variability eDISH • The three primary acinar zones of liver represented • Essential cellular processes represented to multiple scales in interacting sub- models • Over 80 detailed representations of optimization or validati
Slide 7: DILIsym Utilizes Various Data Types to Inform Decisions
DILIsym Utilizes Various Data Types to Inform Decisions Exposure Data Modeling & PBPK Modeling Simulation • Compound Properties - Tissue partition coefficients Simulations and Assays inform: • Tissue penetration studies • Prediction of DILI risk - Liver to blood ratio • Participating DILI mechanisms
Slide 8: DILI-sim Consortium Membership Benefits
Consortium Distributing and Developing Software for Predicting and Preventing Drug-Induced Liver Injury (DILI) ; Dr. Paul B. Watkins Join Today and Support Cutting Edge cna eicimeaaicon mane Research to Make Patients Safer! gp Benefits of Stage 4 DILI-sim Membership * Two global, floating end-user l
Slide 9: Highlights of DILIsym Version X (DSX)
Highlights of DILIsym Version X (DSX) • Completely new software platform! – Much faster and more user friendly – Command line and GUI options – No reliance on MATLAB runtime or base MATLAB – Server/cloud computing capability coming soon….. • 4 NEW exemplar Compounds included with varying clinical pr
Slide 10: Species Differences in Liver Safety Profile for PF-04895162
Howell, Scott Q. Synergy Between Two Mechanisms of Action Contributes to Species Differences in the Liver Safety Profile for PF-04895162 Vinal V. Lakhani**, Grant Generaux"*, Yuching Yang’, Sashi Nadanaciva?, Luping Qiu®, Keith Riccardi‘, Li Dit, Brett A. ler, Paul B. Watkins®5, Hugh A. Barton’, Mic
Slide 11: Efavirenz DILIsym Analysis
Introduction Results Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other agents to treat human immunodeficiency virus (HIV) infection. Efavirenz treatment is associated with a low frequency of serum enzyme elevations’. To understand the hepatotoxicity
Slide 12: The DILIsym X Workspace is Organized According to Projects
The DILIsym X Workspace is Organized According to Projects, Not SimSingles • Projects are started or opened which contain one or more SimSingles, but also other settings files • SimSingles are created within a given project • This organization allows for improved overall project organization and man
Slide 13: Running Parallel Simulations in DILIsym
Running Parallel Simulations in DILIsym • The Parallel tab allows users to run several SimSingles, SimPops, or Sweeps in parallel • Utilizes selected number of threads • Excellent feature for collection of simulations that need to get completed over an extended period of time (e.g. overnight) CONFID
Slide 14: Live DSX Demonstration
Live DSX Demonstration CONFIDENTIAL 14
Slide 15: Questions?
QUESTIONS? https://www.simulations- plus.com/contact/ CONFIDENTIAL 15
Simulations Plus — Technical Presentation (October 2020) on 6ix