Kane Biotech Inc. · TSXV:KNE
Kane Biotech — Military Health System Research Symposium (MHSRS) (2026)
21 slides from Kane Biotech's conference presentation, 2026
Slide 1: Broad-Spectrum, Cavity-Filling Antimicrobial Gel to Address Prolonged Field Care Wound Challenges
i 2 I 3 I a { 3 I é n 7 i 8 IL BROAD-SPECTRUM, aA CAVITY-FILLING ee cess I ANTIMICROBIAL GELTO — ~<— ADDRESS PROLONGED - << FIELD CARE WOUND : CHALLENGES MITIGATING THE 72-HOUR BIOFILM THREAT IN MULTL-DOMAIN CONTESTED EVACUATIONS | r Military Health System Research Symposium (MHSRS) qlee: Col Steven
Slide 2: The Paradigm Shift: From the "Golden Hour" to Prolonged Field Care (PFC)
The Paradigm Shift: From the "Golden Hour" to Prolonged Field Care (PFC) The Golden Hour (OEF / OIF) <=> hy \ aera Military MEDEVAC Forward Surgical Tent Historically, the average time to care was reduced to ~45 minutes. Air superiority guaranteed rapid transport, yielding exceptionally high surviva
Slide 3: The Biological Threat: When Time Works Against Us
The Biological Threat: When Time Works Against Us Operational Care Point Tactical 5 , Of injury Field Care | Prolonged Field Care Window Green Zone 4 Attachment and EPS matrix Planktonic (free-floating) formation begins. Se bacteria. Highly susceptible Le i to standard care. | | | emma = Amber Zone
Slide 4: References
Owens BD, et al. J Orthop Trauma. 2007;21:254-257. Petfield JL, et al. Mil Med. 2022;187(Suppl 2):25-33. Tribble DR, et al. Surg Infect. 2018;19:494-503
Slide 5: The Geometry of Combat Trauma Defies Standard Dressings
The Geometry of Combat Trauma Defies Standard Dressings The Clinical Reality (3D Cavities) Undermining: 10cm Lateral 3D. Blast injuries my create irregular bn a = geometries with Depth extensive tissue 5 = destruction. |. Undermining: ————> | 10cm Lateral >| Combat trauma is The Standard of Care Fai
Slide 6: The Capability Gap in Current TCCC/PFC Doctrine
The Capability Gap in Current TCCC/PFC Doctrine Hemorrhage control Airway management - v- - Hypothermia prevention v- v- ¢ Systemic antibiotics fail to penetrate devitalized tissue and biofilms. Analgesia Simple dry dressings THE IDENTIFIED GAP: No continuous, geometry-independent, anti-biofilm inte
Slide 7: Design Criteria for the Future Battlefield Solution
Design Criteria for the Future Battlefield Solution i || Logistics Light ner old-Chain Independen 7, Low SWaP (Size, Weight, and [ee Shelf-stable across extreme 4 Power). <1kg weight, requiring no -30°C I operational temperatures = external power or suction. (-30°C to 50°C). _3e %) i |! Biological E
Slide 8: Introducing revyve™ Antimicrobial Wound Gel
Introducing revyve™ Antimicrobial Wound Gel The Tactical-Biological Blueprint for Austere Wound Management. [Y Self-Administrable [4% Zero Power [4% Shelf-Stable [{Y Universal 3D Conformation [4% Low SWaP {Y Biofilm Disruption ¢ Anovel, sprayable, thermo-reversible antimicrobial hydrogel. * Patented
Slide 9: Anatomy of the Gel: Integrated Microenvironment Control
Anatomy of the Gel: Integrated Microenvironment Control BE Biofilm <o<, Disruption Active Agents: Poloxamer 407 + EDTA/Citrate Chelators. Physically destabilizes the metal-dependent biofilm Extracellular Polymeric Substance (EPS) matrix. yoy Broad-Spectrum Eradication Active Agent: Polyhexanide (PHM
Slide 10: The Physics of Application: Shear-Thinning Delivery
THE PHYSICS OF APPLICATION: SHEAR-THINNING DELIVERY ( = f =I THE CORE MECHANIC CONTACT-FREE APPLICATION »> #1 t—> The product natively exists in the can High-velocity shear force from the actuator as a thick gel. temporarily thins the gel, allowing it to be sprayed from a safe distance (3-4 inches).
Slide 11: Slide 11
Slide 12: Sustained Hold, Atraumatic Re-entry
Sustained Hold, Atraumatic Re-entry Stable When Warm Prolonged \ Protection _ The Tactical Advantage Current gauze interventions require painful, tissue-tearing manual extraction. revyve liquefies instantly with chilled saline. C S Reversible When Chilled Atraumatic Removal Workflow Impact 7 2 te ©
Slide 13: Synergistic Biofilm Disruption
Synergistic Biofilm Disruption Chelators & Surfactants PHMB (Polyhexamethylene Biguanide) pH & Moisture Regulation Actively strip metal ions and A broad-spectrum antimicrobial agent that Maintains a slightly acidic destabilize the extracellular infiltrates the disrupted, weakened matrix environment
Slide 14: Sustained Protection for Prolonged Field Care
ET ES Viable numbers (Log CFU/mL) Bacterial Biofilm Load Day 1 Day 3 Sustained Protection for Prolonged Field Care Time in Prolonged Field Care a a SS ae ¢ Sustained In-Vitro Performance The gel maintains active antimicrobial and antibiofilm activity for >7 days. a, Standard Intervention The revyve
Slide 15: S. aureus and P. aeruginosa Log Reduction
S.aureus and P.aeruginosa >3.5 Log reduction >6 Log reduction >6 Log reduction
Slide 16: Clinical Bioburden Reduction
Clinical bioburden reduction RED = High Reduction in Bioburden Bioburden Reduction of bacterial bioburden as measured by fluorescence
Slide 17: Wound Healing
Wound Healing Rapid healing in chronic leg ulcers
Slide 18: Concept of Employment (ConEmp) for Role & Care
Concept of Employment (ConEmp) for Role 1 & 2 Care SPRAY (Point of Injury / Role 1) STABILIZE RE-ENTER (Role 2/ Forward Surgical) (Prolonged Field Care / En Route) 4 Contactless, geometry-independent delivery from a distance (3-4 inches). Takes <30 seconds. Integrates directly into the MARCH/MIST wo
Slide 19: Capability Comparison: Standard of Care vs. Thermoreversible Gel
Capability Comparison: Standard of Care vs. Thermoreversible Gel | Operational Dimension (Cam ett Thermoreversible Spray Gel j_omvoncae | alrmarctmesy [nat tatin a a. | esesesnan | erence J Uta set stain Pannen aon ecmealsuppna) | wikood sane ery { << » SFS=
Slide 20: Strategic Impact: Preserving the Force in Austere Environments
Strategic Impact: Preserving the Force in Austere Environments Pr. } "Reduced Surgical & Logistical Burden Reduces reliance on bulky, power-heavy NPWT and systemic antibiotics. Delivers a stabilized, much cleaner wound bed to Role 3 surgical teams upon arrival. Decreased MEDEVAC Demand Decouples the
Slide 21: Broad-Spectrum, Cavity-Filling Antimicrobial Gel to Address Prolonged Field Care Wound Challenges
i 2 I 3 I a { 3 I é n 7 i 8 IL BROAD-SPECTRUM, aA CAVITY-FILLING ee cess I ANTIMICROBIAL GELTO — ~<— ADDRESS PROLONGED - << FIELD CARE WOUND : CHALLENGES MITIGATING THE 72-HOUR BIOFILM THREAT IN MULTL-DOMAIN CONTESTED EVACUATIONS | r Military Health System Research Symposium (MHSRS) qlee: Col Steven
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