Cardiff Oncology, Inc. · NASDAQ:CRDF
Cardiff Oncology — Investor Presentation (November 2022)
72 slides from Cardiff Oncology's investor presentation, November 2022
Slide 1: Company Overview: The Onvansertib Opportunity
Company Overview The Onvansertib Opportunity
Slide 2: Forward-looking statements
Forward-looking statements CERTAIN STATEMENTS IN THIS PRESENTATION ARE FORWARD-LOOKING within the meaning of the Private Securities Litigation Reform Act of 1995, These statements may be identified by the use of words such as “anticipate,” "believe," "forecast," "estimated" and "intend" or other sim
Slide 3: Our Drug: Onvansertib
Our Drug: WHAT Onvansertib WHERE WHY
Slide 4: Our Drug: Onvansertib properties
Our Drug: PROPERTIES • SPECIFICITY Onvansertib • •
Slide 5: Targets with oncogenic alterations
Targets with Targets without oncogenic oncogenic alterations alterations
Slide 6: What, Where, Why
OS cardiff Oncology” Onvansertib has achieved Cardiff Oncology is going Onvansertib works
Slide 7: What, Where, Why
Scarditt Oncology~ OO0O00 WHAT Onvansertib has achieved 05°52 WHERE Cardiff Oncology is going WHY 9 Onvansertib works
Slide 8: 1st Line, 2nd Line
Normal 1st LINE 2nd LINE Mutated
Slide 9: 1st Line, 2nd Line historical ORR
Normal 1st LINE 2nd LINE HISTORICAL* ORR 5% Mutated 11.4% 13%
Slide 10: 1st Line, 2nd Line
Normal 1st LINE 2nd LINE Mutated
Slide 11: KRAS/NRAS Mutations in mCRC
KRAS/NRAS Mutations in mCRC1
Slide 12: KRAS/NRAS Mutations in mCRC
KRAS/NRAS Mutations in mCRC1 93%
Slide 13: MOA: KRAS/NRAS Mutations in mCRC
KRAS/NRAS Mutations in mCRC1 MOA 1 2
Slide 14: Trial design: 28 day cycle
ENROLLMENT CRITERIA SINGLE ARM TRIAL 28 DAY CYCLE
Slide 15: Trial design: 28 day cycle
ENROLLMENT CRITERIA SINGLE ARM TRIAL 28 DAY CYCLE 1 2 3
Slide 16: Objective Response Rate for mCRC trial exceeds SoC over time
Objective Response Rate for mCRC trial exceeds SoC over time Onvansertib+SoC ORR over time RP2D % mmm 8 of 19 42% ° ALL DOSES m= 36% ALL DOSES 38% phase 35% 17 of 487 . . Ol Historical SoC* ORR 5 of 14 34% RP2D 12 of 35+ 11.4% 13% 5% TP if T T T T T T T 2008 13 ‘17 Jan Apr Jul Oct Jan * 2008: Bennou
Slide 17: Strong, durable response with onvansertib + SoC
Patients achieved a strong, durable response with onvansertib + SoC Best Radiographic Response® -— all doses (as of July 25, 2022) 100 All ° mm Complete Response mm Partial Response mim Stable Disease Doses RP2D 3 @ Confirmed CR @ Confirmed PR: m= Progressive Disease . . & %* Patients treated at the
Slide 18: Initial PRs up to eight months on treatment
We observe initial PRs up to eight months on treatment oO oO o oO e a cy 3 8 oe = Swimmer plot* — all doses (as of July 25, 2022) oO fo} fo} fo} oO oO 2 re} e oe fo} ce} re} ro} . 3 0 ¢ Evaluable Patients — all doses 48 S 2 oO 2 o <a : o o ie} n ert = Time of initial PR o o o ‘On Trial On Follow Up
Slide 19: KRAS Variant response
KRAS Variant CR+PR SD PD Total
Slide 20: Progression Free Survival exceeds SoC over time
Progression Free Survival for mCRC trial exceeds SoC over time Onvansertib+SoC mPFS - as of July 25, 2022 ALL DOSES Historical SoC* mPFS (mo) ==9 4 mot ==9 4 mot 9.3 mot RP2D 2008 2013 2017 oI: Jan Apr Jul Oct t Onvansertib mPFS are interim data from an ongoing trial and unlocked database * 2008: Be
Slide 21: What, Where, Why
fe) Os Cardiff Oncology~ WHAT 3 Onvansertib has achieved OOO00 WHERE Cardiff Oncology is going 05°52 WHY 9 Onvansertib works
Slide 22: Goals 2023-2025
2023 2024 2025 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 GOALS 1 2
Slide 23: Demonstrate, Confirm, Position, Operate
DEMONSTRATE CONFIRM POSITION OPERATE
Slide 24: Trial design: 28 day cycle
ENROLLMENT CRITERIA 28 DAY CYCLE
Slide 25: Enrollment criteria and endpoints
ENROLLMENT CRITERIA ENDPOINTS Primary Key Secondary Other Secondary
Slide 26: Combination trials and investigator-initiated trials
Combination with: Preclinical Ph1/2 Ph2/3 Status Investigator-initiated trials Investigator
Slide 27: What, Where, Why
WHAT 3 Onvansertib has achieved WHERE Cardiff Oncology is going @) O Ie OOS WHY 9 Onvansertib works O e)
Slide 28: Onvansertib's safety profile
Onvansertib’s safety profile
Slide 29: MOA: KRAS hypersensitivity and synergy with chemo
KRAS HYPERSENSITIVITY1 SYNERGY WITH CHEMO S G2 G1 M MOA 1 MOA 2
Slide 30: MOA: KRAS hypersensitivity and synergy with chemo
KRAS HYPERSENSITIVITY1 SYNERGY WITH CHEMO S G2 G1 M MOA 1 MOA 2
Slide 31: Tumor cell cycle: DNA replication phase
DNA REPLICATION PHASE S G2 TUMOR CELL CYCLE G1 M
Slide 32: Tumor cell cycle: growth phase
DNA REPLICATION PHASE CELL GROWTH PHASE S G2 TUMOR CELL CYCLE G1 M
Slide 33: Tumor cell cycle: cell growth phase
CELL GROWTH PHASE S G2 TUMOR CELL CYCLE G1 M
Slide 34: Tumor cell cycle: cell growth phase
CELL GROWTH PHASE S G2 TUMOR CELL CYCLE G1 M
Slide 35: Targets with oncogenic alterations
Targets with Targets without oncogenic oncogenic alterations alterations
Slide 36: Multiple important catalysts over the next two years
We have multiple important catalysts over the next two years mPDAC TNBC mCRC data readout data readout randomized data readout SCLC data readout Gg ONSEMBLE mCRC Clinical Trial 39 23 15 0 lJ mCRC mPDAC TNBC SCLC 2L K/N-mut 2b 2Linvasive Salvage 36
Slide 37: At September 30, 2022, our financial position is robust
At September 30, 2022, our financial position is robust mPDAC TNBC mCRC data readout data readout randomized data readout SCLC data readout QONSEMBLE mCRC Clinical Trial September 30, 2022 cash and investments® $114.3M Net cash used in Operating Activities” (Rolling two-quarter period ending Sept. 3
Slide 38: Pfizer Breakthrough Growth Initiative summary terms
Pfizer BREAKTHROUGH GROWTH INITIATIVE SUMMARY TERMS • • • • •
Slide 39: KRAS-Mutated Metastatic Colorectal Cancer (mCRC)
KRAS-Mutated Metastatic Colorectal Cancer (mCRC)
Slide 40: Summary of onvansertib mCRC Ph1b/2 trial data over time
Summary of onvansertib mCRC Ph1b/2 trial data over time Data Cutoff Date Evaluable Patients ORR (CR+PR) Confirmed CR/PRs Duration of Response mPFS Disease control rate (CR+PR+SD) * Data releases include certain follow up data and reflect interim data from an ongoing trial and unlocked database ASCO
Slide 41: No major/unexpected toxicities
GRADE GRADE No major/unexpected toxicities TEAEs* 1 2 3 4 All TEAEs* 1 2 3 4 All • • •
Slide 42: Trial design: Phase 1b/2, 28 day cycle
ENROLLMENT CRITERIA SINGLE ARM TRIAL PHASE 1b PHASE 2 28 DAY CYCLE
Slide 43: Progression Free Survival for mCRC trial exceeds SoC
Progression Free Survival for mCRC trial exceeds SoC over time Progression free survival® — all doses (as of July 25, 2022) gs 1.00 5 2 a nn Historical SoC* mPFS (mo) 4 0.75 4 5.6 4 _/ 45 2 0.504 a i 0.25 5 2008 2013 2017 0.00 ~ Median PFS: 93 0 5 10 15 20 Months * mPFS is interim data from an ongoi
Slide 44: Predictive response biomarker
% KRAS Mutant Allelic Frequency (MAF)* Predictive response biomarker • • •
Slide 45: Early changes in KRAS MAF predict clinical response
Early Changes in KRAS MAF predicts clinical response ORR (%) KRAS RESPONDERS 64% 14 of 22 KRAS NON-RESPONDERS 9% 2 of 23 mPFS (mo) KRAS RESPONDERS 12.6 mo KRAS NON-RESPONDERS 6.0 mo Probability of Survival 1.005 0.50 + 0.25 5 0.00 ~' Onvansertib ORR and mPFS are interim data as of July 25, 2022 from
Slide 46: Historical reference PFS and OS
HISTORICAL REFERENCE PFS OS 5.7 11.2 4.5 11.5 5.6 —
Slide 47: Design and stats
ENROLLMENT CRITERIA DESIGN • • • • STATS • • •
Slide 48: KRAS-Mutated mCRC Bevacizumab Subgroup Data
KRAS-Mutated Metastatic Colorectal Cancer Bevacizumab Subgroup Data
Slide 49: Trial patient demographics reflect 2nd line mCRC population
The trial’s patient demographics reflects 24 line mCRC population Enrollment* Number of Patients (N) Treated Currently on treatment Total Patients N=50 Age (years) Sex Male Female ECOG 0 1 Primary tumor site Colon Rectum Other * Data are interim as of July 25, Phase 1b, Dose Level 0 Onvansertib 12 m
Slide 50: 1st Line, 2nd Line mCRC Ph1b/2 trial
1st LINE 2nd LINE Normal mCRC Ph1b/2 trial RAS Mutated
Slide 51: 2nd line efficacy data from historical trials in mCRC
2nd LINE EFFICACY DATA FROM HISTORICAL TRIALS IN mCRC Normal 2nd Line ORR3-6 2nd Line mPFS (mo)1-2 2nd Line mOS (mo)1-2 RAS Mutated
Slide 52: Historical controls vs onvansertib Ph1b/2 data
2nd LINE HISTORICAL CONTROLS VS ONVANSERTIB* Ph 1b/2 DATA Normal 2nd Line ORR3-6 2nd Line mPFS (mo)1-2 RAS Mutated
Slide 53: No single patient characteristic explains observed ORR difference
No single patient characteristic explains observed ORR difference No Yes (naïve) (exposed) N=
Slide 54: Actions and opportunity
How should we respond ACTIONS to this observation? No Yes (naïve) (exposed) OPPORTUNITY
Slide 55: Bev naive patients durability
All Doses RP2D Bev naïve patients Durability
Slide 56: Bev naive vs Bev exposed best response
No prior bev exposure (naïve) Bev exposure in 1st line Best response of: CR/PR SD PD
Slide 57: Initial PRs up to eight months on treatment
We observe initial PRs up to eight months on treatment ‘oo 294 90000869 oO 090 9° loo, 12] #ePPPonceeto09g0G 95) Pog ,° 999900" jop000090%0g ie} > 3 fe} su ° e o io} o o 8 > ° 5 > ° a ° 8 > ry e e 1 > ie} 9969 g e ie) D0 e— eee, © 080 0° Cogehs ° erie ee [ele} eee e On Trial (On Follow Up On Treatme
Slide 58: Metastatic Pancreatic Adenocarcinoma (mPDAC)
Metastatic Pancreatic Adenocarcinoma (mPDAC)
Slide 59: Trial design: 14 day cycle
ENROLLMENT CRITERIA SINGLE ARM TRIAL 14 DAY CYCLE
Slide 60: Trial design: 14 day cycle
ENROLLMENT CRITERIA SINGLE ARM TRIAL 1 14 DAY CYCLE 2 3
Slide 61: Enrollment criteria and historical response rate
ENROLLMENT CRITERIA HISTORICAL RESPONSE RATE* SINGLE ARM TRIAL 7.7% ORR 14 DAY 20% CYCLE HISTORICAL mPFS* 3.1 mo ≥6 mo
Slide 62: Early data from our mPDAC trial is encouraging
Early data from our mPDAC trial data is encouraging Swimmer plot* — as of August 30, 2022 Change in tumor size from baseline* [e) [e) {e) a [e) fe) Oo 6 @ 04-012 fe) fe) > g 20 (a! H [ a o 2 0 2 4 6 Months 7 E a t 704-008! < 05-014 © ¢<-——_-»—______e 05.009 0 2.5 5.0 7.5 Months 2 «a -20 aang On Trea
Slide 63: Investigator-Initiated Trial: Triple Negative Breast Cancer (TNBC)
Investigator-Initiated Trial Triple Negative Breast Cancer (TNBC)
Slide 64: Onvansertib + paclitaxel is superior to single agent therapy
Onvansertib + paclitaxel is superior to single agent therapy TRIAL RATIONALE In vivo efficacy of onvansertib in combination with paclitaxel Tp53-Mutant SUM159 xenografts* The combination of onvansertib + paclitaxel = 1200 showed significant synergy S E _ control (n=8) =) 3 800 > IS) 600 paclitaxel (
Slide 65: Trial design: 28 day cycle
ENROLLMENT CRITERIA PRIMARY ENDPOINTS − 28 DAY CYCLE
Slide 66: Trial design and endpoints
ENROLLMENT CRITERIA PRIMARY ENDPOINTS − 28 DAY CYCLE SECONDARY ENDPOINT
Slide 67: Investigator-Initiated Trial: Small Cell Lung Cancer (SCLC)
Investigator-Initiated Trial Small Cell Lung Cancer (SCLC)
Slide 68: Onvansertib demonstrates single-agent activity in SCLC
Onvansertib demonstrates single-agent activity in SCLC TRIAL RATIONALE In vivo efficacy of onvansertib monotherapy (SCLC xenografts)* Onvansertib monotherapy CISPLATIN RESISTANT CISPLATIN SENSIVITVE showed significant tumor = 2000 2000 growth inhibition against € con. platinum-sensitive and “> -resi
Slide 69: Trial design: 21 day cycle
ENROLLMENT CRITERIA PRIMARY ENDPOINT SECONDARY ENDPOINTS 21 DAY CYCLE
Slide 70: PARPi Pre-Clinical Data
O00 . Lo. OOO PARP Pre-Clinical Data Ooo
Slide 71: Onvansertib + PARP inhibitors
Onvansertib + PARP inhibitors
Slide 72: Onvansertib + PARP inhibitors: Probability of Survival
Onvansertib + PARP inhibitors* Probability of Survival
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