Nkgen Biotech Inc. · OTC:NKGN
Nkgen Biotech — Graf Acquisition Corp. IV — SPAC Merger (July 2023)
25 slides from Nkgen Biotech's SPAC merger presentation, Jul 17, 2023
Slide 1: Maximizing Immune Integrity Case Studies – Supplemental Materials
For Investor Use Only Confidential Maximizing Immune Integrity Case Studies – Supplemental Materials* July 2023 *This presentation is intended to supplement the investor presentation filed as Exhibit 99.1 to form 8-K with the SEC on July 17, 2023
Slide 2: Disclaimers
Confidential Disclaimers This supplemental presentation (the “Presentation”) has been prepared by NKGen Biotech, Inc. (“NKGen,” “NKGen Biotech” or the “Company”) for informational purposes only and to assist interested parties in making their own evaluation with respect to the business combination (
Slide 3: Forward-Looking Statements
Confidential Forward-Looking Statements This Presentation includes forward-looking statements regarding, among other things, the plans, strategies and prospects, both business and financial, of Graf and the Company. These statements are based on the beliefs and assumptions of the management of Graf
Slide 4: Notice on compassionate use patient videos
Confidential The first set of videos that you are about to view are of two patients with Alzheimer’s disease (“AD”) who received our product candidate, SNK01, through the compassionate use access program. Individual patient results from compassionate use access, including but not limited to, the pat
Slide 5: Case Studies
Confidential Case Studies 5
Slide 6: Compassionate Use Case Study: PSEN1 Mutation and Advanced Alzheimer's Treated with SNK01
Confidential Compassionate Use Case Study # 1 38 y.o. with PSEN1 Mutation and Advanced Alzheimer’s Treated with SNK01 THESE REPORTS OF PATIENT EXPERIENCES AND IMAGES HAVE NOT BEEN VERIFIED OR VALIDATED. ONLY CONTROLLED CLINICAL TRIALS CAN SUPPORT BENEFIT FOR PATIENTS. THESE CASE STUDIES MAY NOT BE P
Slide 7: Compassionate Use Case Study #1 Baseline and After Doses of SNK01
Confidential Compassionate Use Case Study #1 Baseline and After 3 Doses of SNK01 7 Prior to treatment, patient was unable to talk, get out of a wheelchair by himself, hold a pen, or feed himself. Baseline After 3 Doses • Daniel was able to eat noodles with chopsticks for the first time in many month
Slide 8: Compassionate Use Case Study #1 After Doses of SNK01 (Videos 1-3)
Confidential Compassionate Use Case Study #1 After 3 Doses of SNK01 8 Video 1 Video 2 Video 3 10/13/20 10/13/20 10/13/20 THESE CASE STUDIES ARE ANECDOTAL AND UNCONTROLLED. LASTING OR LONG-TERM EFFECTS HAVE NOT BEEN STUDIED. THESE REPORTS OF PATIENT EXPERIENCES AND IMAGES HAVE NOT BEEN VERIFIED OR VA
Slide 9: Compassionate Use Case Study #1 After Doses of SNK01 (Videos 4-6)
Confidential Compassionate Use Case Study #1 After 5 Doses of SNK01 9 1/5/21 5/19/21 "Hi Dr. Song, it was really nice catching up. Here are some messages I have of Daniel’s Board and Care reporting falls due to balance issues, videos of Daniel having difficulty walking and wearing a helmet as the Bo
Slide 10: Compassionate Use Case Study: Advanced Alzheimer's Treated with SNK01
Confidential Compassionate Use Case Study # 2 70 y.o. with Advanced Alzheimer's Treated with SNK01 After six treatments over the period of July 2020 to December 2020, the patient's family noticed improvements in the patient's overall cognitive function. 10 Video 7 Please refer to the Appendix attach
Slide 11: Compassionate Use Case Study #2: Immediate Changes After First Dose
Confidential Compassionate Use Case Study #2 After First Dose, Immediate Changes Observed, Even After a Two-Year Hiatus 11 Week 3 Week 5 Patient was granted single Compassionate Use IND approval by USFDA "By the way. Everyone sees a different Janice recently. Energy. Eye contact. General interaction
Slide 12: Compassionate Use Case Study #2: Observations After 11 Weeks
Confidential t is a Compassionate Use Case Study #2: Observations After 11 Weeks Week 8 Patient is more energetic, alert and interactive Week 9 Patient is able to feed herself after not having been able to do so in years Week 11 Patient can now hold her urine for longer periods. Patient is able to u
Slide 13: Compassionate Use Case Study: Female With Advanced Alzheimer's Treated with SNK01
Confidential Compassionate Use Case Study # 3 - 79 Y.O. Female With Advanced Alzheimer’s Treated with SNK01 Legend MMSE Score Stage ≤12 Severe Dementia 13-20 Moderate Dementia 20-25 Mild Dementia ≥25 No Cognitive Impairment THESE CASE STUDIES ARE ANECDOTAL AND UNCONTROLLED. LASTING OR LONG-TERM EFFE
Slide 14: Phase I Clinical Trial Patient #15 with Alzheimer's Disease Treated with SNK01
Confidential 14 Phase I Clinical Trial Patient #15 85 Y.O. with Alzheimer's Disease Treated with SNK01 SNK01-MX04 Clinical trial, NCT04678453 "Subject 015. His walk was slower, and he couldn't dance and coordinate at the same time since a long time ago. See attached." •Email message from Study Coord
Slide 15: Thank you
Confidential Thank you
Slide 16: Appendix
Confidential Appendix
Slide 17: Video 1 audio transcript
Confidential 17 Transcript of the Videos VIDEO 1 - 10/13/20 - far left [3:25 minutes] eating with chopsticks Brother: Daniel, how’s the food? Patient: Good. Brother: What are you eating? Patient: Pho. Brother: Do you like it? Patient: Yeah. Brother: Awesome. Brother: Want to try eating by yourself?
Slide 18: Video transcript (continued)
Confidential 18 Transcript of the Videos VIDEO 1 continued Patient: OK. Brother: You did pretty good the first time. Patient: Yeah. Brother: Wow Daniel, thanks impressive. You haven’t used chopsticks in a long time. That’s amazing. Patient: (laughs) Brother: Wow. Patient: …(inaudible) Brother: The w
Slide 19: Video 2 transcript (continued)
Confidential 19 Transcript of the Videos VIDEO 1 continued Brother: No, you are eating this. What is this? Patient: Chicken Brother: Yeah, you are eating chicken Pho. Patient: (laughs) Brother: Wow, Daniel. Can you pick up the yolk? Patient: Yeah. Brother: Ok, try picking it up. That was close. Pati
Slide 20: Video 3-5 transcripts
Confidential 20 Transcript of the Videos VIDEO 3 - 10/13/20 video – far right [1:00 minute] – shooting basketball Brother: Daniel, try dribbling the ball. Try dribbling it. Brother: No, no. Don’t pass it to me, dribble the ball. Dribble. Patient: (laughs) Brother: There you go, nice, nice. Now pick
Slide 21: Video 6-7 transcripts
Confidential 21 Transcript of the Videos VIDEO 6 - 5/19/21 video – right [00:57.51 minutes] exercising Brother: Ok, so Daniel is going back and running again. He’s nonstop running. This is crazy. Brother: I haven’t seen Daniel run in so many month. He’s trying to get his legs to move. But… it’s kind
Slide 22: Video transcript (continued)
Confidential 22 Transcript of the Videos VIDEO 8 continued Patient: -ay Husband: Say Thursday. Thursday Patient: Too Husband: Friday Patient: Friday too Husband: Saturday Patient: Hmm? Husband: Say Saturday Patient: Yeah Husband: Saturday Patient: ya too too Husband: Sunday Patient: Yeah Husband: Sa
Slide 23: Video transcript (continued)
Confidential 23 Transcript of the Videos VIDEO 8 continued Husband: One, say one Patient: One Husband: Two Patient: Two too Husband: Three Patient: *laughs* Husband: Four. Say four Patient: Four Husband: Five. Say five Patient: Five Husband: Six, Six Patient: Six Husband: Seven Patient: Too much wha
Slide 24: Video 8-10 transcripts (continued)
Confidential 24 Transcript of the Videos VIDEO 8 continued Husband: Eight. Patient: Yeah Husband: Say eight Patient: Eight Husband: Eight Patient: Eight Husband: Nine Patient: Eight Husband: Nine. Now say nine. Nine Patient: Nine Husband: Ten Patient: Ten Husband: Good Patient: Thank you VIDEO 9 - W
Slide 25: Video 11 transcript
Confidential 25 Transcript of the Videos VIDEO 11 Husband: Janice? Go ahead, go to the car Patient: What? I’m getting. I’m get the…(inaudible)… go take me there. Companion: Um huh. You’re walking by self, oh my goodness. Yes, yes, you’re walking by yourself. Oh my gosh. Patient: See? (laughs). She l