Slide 1: Introduction to Evogene
Introduction to Evogene December, 2015 Ofer Haviv, President & CEO
Slide 2: Safe Harbor Statement
Safe Harbor Statement This presentation contains "forward-looking statements" relating to future events, and we may from time to time make other statements, regarding our outlook or expectations for future financial or operating results and/or other matters regarding or affecting Evogene Ltd. or its
Slide 3: Introducing Evogene
Introducing Evogene We are… A leading ag biotechnology company for the improvement of crop productivity and performance, addressing the increasing demand for food, feed and fuel
Slide 4: Introducing Evogene
Introducing Evogene ¡ Founded in 2002 ¡ Located - § HQ : Rehovot, Israel § R&D site : St. Louis, USA ¡ ~200 employees, 80% R&D ¡ Two R&D hubs for improving crop productivity - § Crop enhancement - yield, drought tolerance and fertilizer use efficiency § Crop protection - insect resistance, disease,
Slide 5: The need for innovation: increasing crop productivity and performance
The need: provide more with less The solution: increasing crop productivity and performance Evogene’s approach for ag-innovation: utilizing scientific understanding and computational technologies to harness the potential of the Ag ‘big data’ revolution Improved Seed Traits Innovative Ag-Chemicals No
Slide 6: Ag 'big data' - an opportunity for ag-innovation
Ag ‘big data’ - an opportunity for ag-innovation *For which ag ‘big data’ is available Ag ‘big data’ “hidden product” >100’s M microbial strains & genes* >10’s M plant genes ~100M chemical molecules* Costs ↓ Quantity ↑ Diversity↑
Slide 7: From ag 'big data' to ag-innovation - the challenge
From ag ‘big data’ to ag-innovation - the challenge *For which ag ‘big data’ is available Product Example - corn with increased yield Only few candidates (genes / SNPs / other) contribute to final product Ag ‘big data’ “hidden product” >100’s M microbial strains & genes* >10’s M plant genes ~100M ch
Slide 8: Evogene's proprietary approach
8 ❷ Computational data analysis ❹ Learning curve ❸ Validation & optimization ❶ Generation and integration of relevant data Evogene’s proprietary approach Harnessing ag ‘big data’ to achieve breakthrough ag-products *For which ag ‘big data’ is available Ag ‘big data’ “hidden product” Product Example
Slide 9: Harnessing ag 'big data' through scientific understanding
Harnessing ag ‘big data’ through scientific understanding & computational technologies Engine driving our innovation: utilizing scientific understanding & computational technologies to harness the potential of the Ag ‘Big Data’ revolution Interdisciplinary R&D expertise • Plant genomics • Plant phys
Slide 10: Evogene's pathways for Ag-innovation
10 Improved Seed Traits Innovative Ag-Chemicals Ag-Biologicals Evogene’s pathways for Ag-innovation Crop Protection Hub (CP) (insect, disease, weed control) Engine driving our innovation: utilizing scientific understanding & computational technologies to harness the potential of the Ag ‘Big Data’ re
Slide 11: Core revenue model and partnerships
Core revenue model and partnerships Business model & partners • Initial revenues : R&D and milestone payments from partners • Primary long-term revenues: royalties from seed traits, ag-chemicals and ag- biologicals • Collaborations with world leading seed and ag-chemical companies
Slide 12: Evogene's pathways for Ag-innovation
12 Improved Seed Traits Innovative Ag-Chemicals Ag-Biologicals Evogene’s pathways for Ag-innovation Engine driving our innovation: utilizing scientific understanding & computational technologies to harness the potential of the Ag ‘Big Data’ revolution
Slide 13: Improved seed traits: market overview and potential
Rapidly growing market* Yield Drought tolerance Insect resistance Herbicide tolerance Disease resistance Soy Trait potential - per crop* 19.3 Herbicide tolerance Additional traits (partial) Improved seed traits Market overview & potential CAGR (09’-13’) +9% 30.8 27.6 34.5 39.4 37.5 $0.65B $3.2B $1.5
Slide 14: Improved seed traits - Crop Enhancement pipeline
Corn 1. Yield Biogemma 2. Drought Biogemma 3. Nitrogen use efficiency Soybean 4. Yield 5. Drought Wheat 6. Yield 7. Drought 8. Nitrogen use efficiency Cotton 9. Yield 10. Drought 11. Nitrogen use efficiency Canola 12. Yield 13. Drought 14. Nitrogen use efficiency 15. Yield 16. Drought 17. Nitrogen u
Slide 15: Improved seed traits - Crop Protection pipeline
Corn 1. Fusarium 2. Lepidoptera 3. Coleoptera (Rootworm) 4. Beet Armyworm Soybean 5. Asian Rust 6. Nematode 7. Lepidoptera 8. Hemiptera Banana 9. Black Sigatoka Cotton 10. Lygus Hesperus Crop Trait Partner Improved seed traits - Crop Protection Current product program pipeline Discovery Phase I POC
Slide 16: Collaboration with Monsanto - example
Gene discovery and trait optimization by Evogene Development and commercialization by Monsanto Improved seed traits Collaboration with Monsanto - example Model plant validation Regulatory Yield Drought Fertilizer utilization Target plant validation and development ¡ Collaboration period - 8 years ¡
Slide 17: Insect control - our motivation and activity to date
Existing insect resistance seed traits - ~4.5B* Dire need for innovation Rising resistance to existing solutions One solution (Bt toxins) does not fit all Improved seed traits - Crop Protection Insect control - Our motivation and activity to date ¢ Market - § Large potential § Significant need due t
Slide 18: Evogene's pathways for Ag-innovation
18 Improved Seed Traits Innovative Ag-Chemicals Ag-Biologicals Evogene’s pathways for Ag-innovation Crop Protection Hub (CP) (insect, disease, weed control) Engine driving our innovation: utilizing scientific understanding & computational technologies to harness the potential of the Ag ‘Big Data’ re
Slide 19: Innovative Ag-Chemicals: market highlight
Huge market - ~$55B* in 2014 Need for innovation - herbicide sector § Rising weed resistance § Growing need for innovation § Rising regulation pressure Innovative Ag-Chemicals Market highlight ($14.85B) ($14.3B) ($1.65B) Rising Glyphosate resistance Less innovative ag-chemicals under development Reg
Slide 20: How does a herbicide work?
Substantial growth in herbicide resistance Herbicide : a chemical that inhibits a process in the weed that is essential to its life Weed control è critical need for novel solutions Innovative Ag-Chemicals - Crop Protection (Herbicides) How does a herbicide work? A weed target protein a macro-molecul
Slide 21: Innovative Ag-Chemicals - current product program status
Row crops 1 . Non-selective herbicide Broad leaves 2. Grasses selective herbicide Grasses 3. Broad leaves selective herbicide Induced Non-induced Crop Application Partner Innovative Ag-Chemicals - Crop Protection (Herbicides) Current product program status Note: Any results, estimates, or calculatio
Slide 22: Collaboration with BASF - example
Targets Hits Target discovery & validation Downstream development Discovery of chemical candidates Candidate chemical screening ¡ Collaboration period - ~3 years ¡ Activities - In-silico target discovery & validation In silico library design Screens Novel herbicides Innovative Ag-Chemicals - Crop Pr
Slide 23: Evogene's pathways for Ag-innovation
23 Improved Seed Traits Innovative Ag-Chemicals Ag-Biologicals Evogene’s pathways for Ag-innovation Crop Protection Hub (CP) (insect, disease, weed control) Engine driving our innovation: utilizing scientific understanding & computational technologies to harness the potential of the Ag ‘Big Data’ re
Slide 24: Ag-Biologicals: market highlight and activity to date
$2.0B $1.2B $6.0B $3.0B Evogene’s current activities - highlights Ag-Biologicals Market highlight and activity to date 2019E Biostimulants - biological products for crop enhancement Biopesticides - biological products for crop protection Why AgBiologicals? ü Relatively short time & low cost to produ
Slide 25: Proprietary seeds - Evofuel Ltd
Castor today Our castor Evofuel castor field, Brazil, 2014 Proprietary seeds - Evofuel Ltd A wholly owned development stage company ¡ Traditional / family farming § Handpicked § Lack equipment § Poor seed quality ¡ Low productivity § World average - ~1ton/ha ¡ Limited supply § c.1.5m ha worldwide §
Slide 26: Corporate information: cash position and stock data
Cash position (September 30, 2015) Corporate ID Stock data Corporate information ¡ ~$106.4M in cash, short term bank deposits and marketable securities ¡ Operating cash burn for 9 month period $10.6M ¡ Based in Rehovot, Israel; US R&D Center in St. Louis, MO ¡ ~200 FTEs, 80% R&D positions ¡ Key mile
Slide 27: Evogene Plant Innovation
evogene Plant Innovation