Gubra A/s · OMXCOP:GUBRA
Gubra A/s — Technical Presentation (June 2023)
28 slides from Gubra A/s's technical presentation, June 2023
Slide 1: RNA-seq data package
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. DATA PRESENTATION RNA-seq data package 2023
Slide 2: Sample clustering analyses
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Sample clustering analyses Principal component analysis DIO-NASH 10 Vehicle 8w Lanifibranor DIO-NASH 12w Vehicle 12w Semaglutide 8w 0 PC2 (
Slide 3: Differential expression analysis
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Differential expression analysis Overview of regulated genes 10000 Number of regulated genes 7733 7907 8000 7190 6000 4000 3318 2000 1783 0
Slide 4: Gene regulation overlaps
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Gene regulation overlaps Overview of compound effect overlap Week 8 Week 12 Lanifibranor 8w Chow + Vehicle 12w Semaglutide 8w 2616 Lanifibr
Slide 5: NASH gene of interest shortlist
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. NASH gene of interest shortlist CD163 antigen CD68 antigen Collagen, type I, alpha 1 Collagen, type I, alpha 2 (Cd163) (Cd68) (Col1a1) (Col
Slide 6: Pathway summary
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Pathway summary Overview of regulations in pathways Bile acid metabolism ECM organization ER stress Log2 Fold Change 3 Semaglutide 8w Lanif
Slide 7: Gene expression data in GubraView
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Gene expression data in GubraView Click HERE to start movie (Movie, click top-left corner to start). Demonstration of the RNAseq database,
Slide 8: Appendix
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Appendix
Slide 9: Bile acid metabolism - 1/2
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Bile acid metabolism Bile acid metabolism - 1/2 ATP-binding cassette, ATP-binding cassette, Cytochrome P450, family sub-family B (MDR/TAP),
Slide 10: Bile acid metabolism - 2/2
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Bile acid metabolism Bile acid metabolism - 2/2 Solute carrier family 22 Solute carrier family 27 Solute carrier family (organic anion (fat
Slide 11: ECM organization - 1/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. ECM organization ECM organization - 1/4 Collagen, type I, alpha 1 Collagen, type I, alpha 2 Collagen, type V, alpha 1 a DIO-NASH Vehicle 8w
Slide 12: ECM organization - 2/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. ECM organization ECM organization - 2/4 Cathepsin K Fibulin 5 Laminin gamma 3 a DIO-NASH Vehicle 8w (Ctsk) (Fbln5) (Lamc3) Semaglutide 8w a
Slide 13: ECM organization - 3/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. ECM organization ECM organization - 3/4 Lysyl oxidase-like 4 Matrix metallopeptidase 2 Matrix metallopeptidase 9 a DIO-NASH Vehicle 8w (Lox
Slide 14: ECM organization - 4/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. ECM organization ECM organization - 4/4 Tissue inhibitor of Tissue inhibitor of Versican metalloproteinase 1 metalloproteinase 2 a DIO-NASH
Slide 15: ER stress
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. ER stress ER stress Activating transcription Activating transcription X-box binding protein 1 factor 4 factor 6 a DIO-NASH Vehicle 8w (Xbp1
Slide 16: Glucose metabolism - 1/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Glucose metabolism Glucose metabolism - 1/3 Forkhead box O1 Glycogen synthase 2 Insulin receptor a DIO-NASH Vehicle 8w (Foxo1) (Gys2) (Insr
Slide 17: Glucose metabolism - 2/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Glucose metabolism Glucose metabolism - 2/3 Ketohexokinase Protein kinase C, iota Protein kinase C, zeta a DIO-NASH Vehicle 8w (Khk) (Prkci
Slide 18: Glucose metabolism - 3/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Glucose metabolism Glucose metabolism - 3/3 Solute carrier family 2 Sterol regulatory (facilitated glucose element binding a DIO-NASH Vehic
Slide 19: Hepatocellular cell death - 1/2
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Hepatocellular cell death Hepatocellular cell death - 1/2 Absent in melanoma 2 Caspase 1 Caspase 3 a DIO-NASH Vehicle 8w (Aim2) (Casp1) (Ca
Slide 20: Hepatocellular cell death - 2/2
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Hepatocellular cell death Hepatocellular cell death - 2/2 Receptor NLR family, pyrin domain NLR family, pyrin domain (TNFRSF)-interacting a
Slide 21: Inflammation - 1/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Inflammation Inflammation - 1/4 Adhesion G Amine oxidase, copper CD14 antigen containing 3 a DIO-NASH Vehicle 8w protein-coupled receptor E
Slide 22: Inflammation - 2/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Inflammation Inflammation - 2/4 CD163 antigen CD68 antigen CD86 antigen a DIO-NASH Vehicle 8w (Cd163) (Cd68) (Cd86) Semaglutide 8w a *** 40
Slide 23: Inflammation - 3/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Inflammation Inflammation - 3/4 Mitogen-activated Toll-like receptor 4 Tumor necrosis factor protein kinase 11 a DIO-NASH Vehicle 8w (Tlr4)
Slide 24: Inflammation - 4/4
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Inflammation Inflammation - 4/4 TNF receptor-associated TNF receptor-associated factor 2 factor 6 a DIO-NASH Vehicle 8w (Traf2) (Traf6) a S
Slide 25: Lipid metabolism - 1/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Lipid metabolism Lipid metabolism - 1/3 Apolipoprotein A-I Apolipoprotein A-V Apolipoprotein C-II a DIO-NASH Vehicle 8w (Apoa1) (Apoa5) (Ap
Slide 26: Lipid metabolism - 2/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Lipid metabolism Lipid metabolism - 2/3 3-hydroxy-3-methylglutaryl 3-hydroxy-3-methylglutaryl Fatty acid synthase Coenzyme A reductase Coen
Slide 27: Lipid metabolism - 3/3
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Lipid metabolism Lipid metabolism - 3/3 Peroxisome proliferator Peroxisome proliferator Squalene epoxidase activated receptor gamma activat
Slide 28: Inflammation signaling
Example of RNA-seq data presentation. All data belong to Gubra. For more details about the study, please refer to the paper published by Møllerhøj et al., 2022. Inflammation signaling Inflammation signaling SMAD family member 2 SMAD family member 3 SMAD family member 4 a DIO-NASH Vehicle 8w (Smad2)