Integragen Sa · EURONEXT:ALINT

Integragen Sa — Séminaire ZYMARK, 13 June 2003, CNG Evry

28 slides from Integragen Sa's conference presentation, Jun 13, 2003

  1. Slide 1: Industrialisation d'une plate-forme d'identification de gènes

    Integravefate Seo do not disclose without written consent from IntegraGen SA Réseau Genhomme « Industrialisation d’une plate-forme d’identification de génes » Francis Rousseau, CTO IntegraGen Séminaire ZYMARK du vendredi 13 juin 2003, CNG Evry « le liquid Handling au cceur de l’automatisation des sc

  2. Slide 2: ( 2( / ) ( 3( %43 (& ) 5( ((

    1 ( 2( / 3 ) ( 3( 4 %43 (& ) 5( 0 (( ( . / . 0

  3. Slide 3: Notre Stratégie

    Notre Stratégie 6 7 / / 3 /( 80 9 ( 66 2 2 2 2:: & &3 3 6 80 ; 3 3/ ) 2 / ( ) ( . / . 0

  4. Slide 4: & &!! & & 0" % % 0" & &!! !! + !! +

    & &!! & & 0" 3 77 % % 0" & &!! !! + 55 !! + # #!! !! 0 0 6 6!! !! 1 1 & & 77 % % ( (!! ## ) )* & *& + + !! !! !! " " - - 11 " " & &!! # # 22 3 3 4 4 ' ' # #!! !! # # " " / / !! " " # # !! # # <, - <, - % % , , - - . . % % !! !! # # " " $% $% ( . / . 0

  5. Slide 5: # $ $ % 9' 9' " / / " : ; " !!

    0 3 # $ $ % 2 9' 9' " 8 / 8 / " : ; 2 3 " 1 1 !! 0 < ;" " " 98" " !! "" ( . / . 0

  6. Slide 6: Plate-forme technologique intégrée

    Plate-forme technologique intégrée Construction de la technologie GenomeHipTM TM et d’outils propriétaires dédiées à un procédé intégré technologie technologie Méthode Méthoderobuste robustecontrôlée contrôléeàà GenomeHIPTM GenomeHIPTM chaque chaqueétape étape SGhip SGhipTMpackage TM package pour la

  7. Slide 7: Two affected members of a family share the same disease genes

    = .0 TWO AFFECTED MEMBERS OF A FAMILY SHARE THE SAME DISEASE GENES KEY: :Non Identical By Descent Elimination of homohybrids (IBD)regions :Identical By Descent (IBD)regions Elimination of non-IBD Fragments DNA fragmentation, Addition of flags Mix DNA and denaturation Hybridisation on DNA chip repres

  8. Slide 8: Determination of the disease loci by exclusion mapping

    Pa — = © E S = © 0 = of = S = _— o o an Determination of the disease loci by exclusion mapping Identification of all the loci implicated in the disease do not disclose without written consent from IntegraGen SA

  9. Slide 9: " 98" - % = > ? (( 0( 2( 3( ) > @A

    " 98" - % = 9 > ? 6 (( 0( 61 3 2( 6 3( 0 ) > @A , 1$ (( (( = /) > 3 ) 3( "B ( . / . 0

  10. Slide 10: D ( EF C## ### (

    > 98" $%? @$% &* 98" # % ( 3 3: C##### ( D ( EF 0. G $ 2 4 : ( > = 7( "H##> ( 5( > ( 3 < ) = %3 & ? I J 2 ( . / . 0

  11. Slide 11: K( L ( = M = M

    0 9 3 = > 2 K( L ( = M 43 0 3 /) ( 3 = M 43 0 3 /) ( ,/&2 (& = (& ) ( 8 (, 0. % % 6 %( 3 (& 2( 0 0 6 $ ( ( & N &J = ( ( &JN & ( . / . 0

  12. Slide 12: *7 ( D %7*G ( >1 >1 >1 D2 (

    .0 2% 72 9' *7 ( 2 3 D %7*G ( 6 >1 2 6 >1 >1 D2 ( &3 (( GI 3 : /&2 ( 3 &JN & 6 >1 PQ / ( R (& ( 6 >1 >1 /) ( 3 3 I 6$ >1 6$ >1 O> - A ( . / . 0

  13. Slide 13: B 3 M D

    ' % B 3 .0 ". 0 M *7 ( "7 D <7: N7 < %0 < : N7 < %0 %7*G * 7 >1 >1 <7: N 7 <% 0 ( >1 D2 < : N7 <% 0 ( &3 (( GI 6 >1 6 >1 3 : /&2 ( 3 PQ / ( R (& 6$ >1 ( " 3 I 6$ >1 1 " $- # I ( . / . 0

  14. Slide 14: Deletion in Dystrophin, chromosome X

    8 " . 0 98" *&2 ?$ ( SSN$ (S 6 98" 8 @ C# 6 98" D@ C A Deletion in Dystrophin, chromosome X 1.00 0.90 *&2 ? 0.80 Ratio male/female $ ( SSN 3 S D ( S3" I <" I G 0.70 0.60 6 98" D@ E A( 0.50 0.40 6 98" @ F A 6 0.30 0.20 Deletion in male patient: Xp21.1::Xp21.3 0.10 0.00 0 20 40 60 80 100 120 140 Chrom

  15. Slide 15: 5( ( 3( <0 / ( ) *7 :: (( T T 2<3 <3

    5( ( 3( <0 / ( ) *7 :: (( T T 2 2<3 <3 ,, 2 2 (( (( 3 3(( <0 <0 * * 7I 7I 00 3 3 ,, (( ! ! (( 88 (,(, 2 2 II (,(, (((( (( " "# # 2 288 " " 2 2II % % 2 2(( 3 3 U U DD (( L L (& (& ) ) GG 00 3 3 ,, :: 00 (( 3 3 (((( ( . / . 0

  16. Slide 16: D> 'L ( VG

    2! 0 (, ( 2 . 0? = 7 3 / ( 0 2( 2 3 2( = ( 3 / ( 3 9 3( 3 0 ( / ( 7 < ) = % 3 2( ( 'L ( - 3 ( 3 D> / 7/ VG ( . / . 0

  17. Slide 17: 1 ( 33 , &: (, 0 DW G

    & 3 ( 43 (' *7- 2! 0 2( ( 2 , / (( NN 1 ( 33 , 3 8 1$ / 1 ( 33 , ( ) 1 ( 33 , &: (, 0 DW G Procédures Puces ADN Statistiques GenHIP Identification des Informatique Loci et gènes (LIMS) (( 2 ( $ ( , 3 ! * 3 ? D G 1 ( 33 W D ( > G ( . / . 0

  18. Slide 18: 7( ( ! * ! ?" ! "##" ( : (, 6X X (

    7( 3 ( 3 ! * 1 3 ! ?" ! "##" 3 ( : (, 2 6X X 3 8 6 3 3 ( 8 0 3( ) 6 , / / H 6 ) , &: 2 ) "## 6 6X 3( 3 3 2 "## 6 W <H 6 W 6 / 4 W H 6 1 ( 33 6 65( ( . / . 0

  19. Slide 19: T ! 6 U 4 YH / (( J# 3

    % 3 ( *7 7 ( ( T! "! L 6 U4YH / (( 2 J# 3 6 ) 3 ? ! D"G 1 2 0 D HG 7 , ( ) DHG 7 ( , / (( D G 6X 3 ? ( D G M( 0 ( DUG 2 D G 1 D G K( ( DUG ( . / . 0

  20. Slide 20: / & 7 E D" 8 H## ZWG

    %4 3 ( *7 67 3( ) 6> 3 , 3 6 2( ( D"8 H##ZWG 6 2( 0 () 8 00 ? / &7 E ! ( 2 8 3( ) 8 3( ) 3( ) 8 3( ) 4 ( ( ( . / . 0

  21. Slide 21: " 8 H## ZW 6 M 9 C 6 M 9 YH D 3(

    , / / 7 3( 0 ( / / ? = 1 2 ( "8 H##ZW 6 M 9 C 6 M 9 YHD 3( ) YH CUG 6 2 3 4) = M ( 9 = 7 6 M 3 0 6 M 3 , = 6 M ( 6 2 ( . / . 0

  22. Slide 22: #A 4 #C 5 ( ( HIJ" W

    %4 3( , / 30 / / 8 ;"& - 4 #C 0 3 ,G& " % 5 ( ( HIJ" W H I (6J1 0 3 ,G& " H I 5 J1 ' % # J1 0 3 . 0" 0 8 3 6)J1 % 3( ) YH * =K L) % 0" 8% 5 0 3 ,G& " 0 3 . 0" * H I !(J1 5 ( @ UHZW 4 UJ 5 ( ( 7( ) YH U W 8% L) ' % &A)J1 &= % + = 7YH . 0 - - #A ( 1 =K 5 =K L) \ 4%UU . 5 ( ( =K L) 0 3 . 0" I" W 5 ( @

  23. Slide 23: 0 3 G 9 5 ( @ J# ZW 0 3 G 8

    %4 3( , / 30 7 / / 0 3 G 9 5 ( @ J#ZW = = $ 0 0 3 G 8 0 3 G 8 $ $ 5 ( @ J#ZW ( J1 =K L) 41 0 3 G 9 5 ( ( 7 5 ( @ ##ZW "IU W 0 3 .G " 0 3 .G " != % + IJ W 5 ( @ "IJZW = = 5 ( @ "IJZW 0 3 .G " L $ ; 7( ) YH L 0 L 3. (( "I" W 4 " # J1 ' % 8% L&! 5 ( ( =K L) #!A (J1 TI" W =K 5 1 # M 0 3 G 9 7 = % # W 4=

  24. Slide 24: 7 E > E = > E <

    ( 3 3 7 3 ! 43 3 40 2 ) 2 = * ( % $ ( 7 E > E < ( & E ( "3 3 = > E < ( 6 > E S "U3 6 9 YH8 K 33 \ C 48 K 3 6 M , = & E 6 ( W* "#3 6 9 YH8 K ( \C 48 K 3 \ "2 (E 6 M ( 8 M( 6 M , 6 J! ( 33 3 ( ( . / . 0

  25. Slide 25: E W* "# 3 9 YH 8 K

    ( = & E 6 ( W* "#3 = "3 ( 3 ( , 6 9 YH8 K ( "8 "##ZW 6 9 C 4 3 8 K ( "8 ##ZW 6 > (E "? ( #ZW 8 "IJ W 6 W ( ( I#D8 3 / I G 6 ( / ) 3 2 0 4) ? = M ( , > (ED & : 0 G 3(: ( DU3 G 3 3 4) 3 8 / / ) ( . / . 0

  26. Slide 26: FIVER EE

    : 7 oa FIVER EE do not disclose without written consent from IntegraGen SA

  27. Slide 27: Q H# ] EG

    5( ( 3( <0 / = ( 3 Q ( D & EG = 7( H#] / 3 ( = ( 3 D $ G = : 3 ? (2 00 ( D! #G 6 % I (, 3 2( ( () = ": 3 ? ( ( 3 ( 33 D! (( = ^#G 6 G 0 ( ( 6 2G ( (, 2( / ( () 3 = : 3 ? ( : 3( D 3 2 #G ( . / . 0

  28. Slide 28: Paris Evry Genopole

    @1 +3 0 Paris Evry Genopole ( . / . 0

IntegraGen — Séminaire ZYMARK, 13 June 2003, CNG Evry on 6ix