Kalvista Pharmaceuticals, Inc. · NASDAQ:KALV
Kalvista Pharmaceuticals — HAEi Global Leadership Workshop, Frankfurt, October 6-9, 2022
13 slides from Kalvista Pharmaceuticals's conference presentation, October 2022
Slide 1: The Global and Regional Impact of HAE Attacks on Mental Health, Daily Living and Quality of Life
The Global and Regional Impact of Hereditary Angioedema (HAE) Attacks on Mental Health, Activities of Daily Living and Quality of Life Paula J. Busse1, Teresa Caballero2, Sally van Kooten3, Sherry Danese4, Ledia Goga3 1Department of Medicine, Division of Clinical Immunology, The Mount Sinai Hospital
Slide 2: Disclosures
Disclosures In relation to this presentation, the authors declare the following, real or perceived conflicts of interest: Paula J. Busse – Advisory Board/Consultant and/or Grant/Research Support: CSL Behring, KalVista Pharmaceuticals, BioCryst Pharmaceuticals, Takeda, Regeneron, Novartis Teresa Caba
Slide 3: Introduction
Introduction HAE is characterized by recurrent and unpredictable episodes of subcutaneous or submucosal swelling affecting the abdomen, extremities, genitals, face, and larynx • Symptoms of an HAE attack may be painful and debilitating, potentially interfering with the ability to conduct daily activ
Slide 4: Objective & Methods
Objective & Methods The objective of this study was to characterize the impact of HAE attacks on the quality of life and activities of daily living for people with HAE Methods • Thirty-two individuals with HAE participated in one of four 2-hour focus groups, held between November 2021 and March 2022
Slide 5: Methods
Methods • Survey included multiple-choice, rank-scale, rank-order or open-ended questions. ‒ 5-10 minutes to complete • Patient privacy was protected by use of pseudonyms; patient health records were not accessed • Analysis was performed using descriptive statistics ‒ Continuous variables summarized
Slide 6: Respondent Location
Respondent Location NORDICS (n=1) UK (n=1) POLAND UNITED STATES GERMANY (n=2) (n=23) (n=2) SAUDI ARABIA UAE (n=1) (n=1) Adult and adolescent participants recruited in collaboration with US HAE AUSTRALIA Association (HAEA) and HAE (n=1) International (HAEi) patient advocacy organizations HAEi Global
Slide 7: Respondent Demographics
Respondent Demographics A total of 32 respondents completed either the pre- or post-survey* Total US International** Baseline demographics (n=32)* (n=23) (n=9) Region US 72% 100% – International 28% – 100% Current Age (Mean, Range) 33 (15 - 72) 33 (15 - 72) 31 (22 - 43) Gender, Female (n, %) 20 (63%
Slide 8: Respondent Characteristics
Respondent Characteristics Total US International** Characteristic (n=32)* (n=23) (n=9) Age of Diagnosis (Mean, Range) 16 (0 - 40) 17 (3 - 40) 12 (0 - 33) Type of Therapy On-demand only 68% 64% 78% Prophylaxis with on-demand for 32% 36% 22% breakthrough attacks 33, 17.5 24, 16.25 56, 40 Attacks Per
Slide 9: Patients feel like 'less than their 100% self' because of HAE nearly half the time
Patients feel like ‘less than their 100% self’ because of HAE nearly half the time ? How often (percent of time) do you feel less than your 100% self because of HAE? Range Total 49% 0% – 100% (n=32) US 49% 0% – 100% (n=23) International 47% 0% – 100% (n=9) 9 HAEi Global Leadership Workshop, Frankfur
Slide 10: When patients do not treat an attack, their plans change two-thirds of the time
When patients do not treat an attack, their plans for the day change two-thirds of the time ? When you do not treat an attack, what percentage of the time do your plans for the day change? Range Total 67% 0% – 100% (n=32) US 62% 0% – 100% (n=23) International 79% 26% – 100% (n=9) 10 HAEi Global Lead
Slide 11: Unpredictable attacks and time spent managing HAE cause substantial anxiety and lower quality of life
Unpredictable attacks and time spent managing treatment of HAE causes substantial anxiety and lowers quality of life ? What is the most significant impact of HAE on your life? Total Percent of respondents that mention (n=32)* US (n=23) International** (n=9) ! I cannot count on participating in impor
Slide 12: Conclusions
Conclusions Results highlight the significant impact that HAE attacks have on people’s ability to participate in daily activities and how the unpredictability of attacks negatively impacts their lives Almost half the time, patients feel, ‘less than their 100% self’ because of their HAE Majority rank
Slide 13: Thank you to all survey participants
Thank you to all survey participants, and those who assisted in the development of the survey, and participant recruitment HAEi Global Leadership Workshop, Frankfurt, Germany, October 6-9, 2022 13
KalVista Pharmaceuticals — HAEi Global Leadership Workshop, Frankfurt, October 6-9, 2022 on 6ix