Niagen Bioscience, Inc. · NASDAQ:NAGE

Niagen Bioscience — ChromaDex — Investor Presentation (June 2011)

47 slides from Niagen Bioscience's investor presentation, Jun 14, 2011

  1. Slide 1: Corporate Presentation

    C ) ChromaDex June 14, 2011 Corporate Presentation

  2. Slide 2: Safe Harbor Disclaimer

    nN Safe Harbor Disclaimer This presentation and other written or oral staternents made from time to time by representatives of ChromaDex contain “forward-looking statements’ within the meaning af Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act af

  3. Slide 3: Health Claims Disclaimer

    Health Claims Disclaimer 3 Statements made in this presentation have not been evaluated by the Food and Drug Administration. ChromaDex products are not intended to treat, cure, prevent or mitigate any disease. The statements in this presentation are for investor relations and educational purposes on

  4. Slide 4: Company Profile

    Company Profile 4 « Science-based company specializing in the high-growth natural products industry + Strong legacy business model provides early access to high-potential proprietary products « First major proprietary product, pler$Pure, has enormous potential in multiple market channels + Strong an

  5. Slide 5: Irvine, CA Boulder, CO

    Irvine, CA Boulder, CO « Ticker symbol: CDXC.OB - Market cap: ~$85M, ~70 employees + ~$3Min cash, no debt Intemal plan for revenue growth from $12-15M in 2011 to over $100M in 3-5 years

  6. Slide 6: Company Profile (cont'd)

    Company Profile (cont'd) Common stock ownership. 11.9% key investor 9.4% Key investor 5.7% Key investor 53% Others with >2% 11.4% Ltd F J A fd oe Allothers 44.5% NU) Weenie Total 100% = Key individuals Profile Role Frank Jakseh Founded ChramDex in 1999. Previously managed CEO international divisions

  7. Slide 7: ChromaDex has focused 3-5 year plans and a huge potential upside

    700 600 500 400 300 200 100 ChromaDex has focused 3-5 year plans and a huge potential upside $Million = Legacy business we a plerePure $100 - 130 3.5 yr revenue projection $505 - 660 a he 3.5 yr revenue upside The total market opportunity for lerPure could greatly exceed internal plan expectations ©

  8. Slide 8: Three keys to rapid growth at ChromaDex

    Three keys to rapid growth at ChromaDex 8 1. Fully commercialize plersPure, ChromaDex’s first proprietary product to market, including retail launch of the BIG Sciencé brand 2. Expand the legacy business 3. Develop follow-on pipeline of proprietary products with intellectual property ©

  9. Slide 9: pteroPure was identified and developed through ChromaDex's legacy business

    yes plersPure was identified and developed through ‘4.5% ChromaDex’s legacy business .. . ok | 9 The legacy business: + Natural Product fine chemicals (phytochemicals and botanicals for laboratory-based R&D and QA) - Analytical and Chemistry-based Services (CRO) ©

  10. Slide 10: Legacy Business Overview — Natural Product Fine Chemicals

    Legacy Business Overview — Natural Product Fine Chemicals mmary of Product Offering + 3000+ plant-based fine chemicals + 800+authenticated botanicals « Comprehensive collection ofthese in the form of natural product libraries Small quantities ofthese products are used for R&D and QAin the following

  11. Slide 11: Legacy Business Overview — Analytical and Chemistry-based Services

    Analytical Services » Identity Testing « Potency Testing « Safety Testing Verification of Label Claims R&D Services Method Development & Validation « Process Development Synthetic Chemistry Fermentation Consulting Services GMP Compliance Raw Material Selection QC/QA Program Development Legacy Busine

  12. Slide 12: The legacy business is poised for rapid growth based on industry trends

    The legacy business is poised for rapid growth based on trends within the Natural Products Industry . Natu fal products industry expectedto « Higher demand fornatural reach $155B by 2015" productlibraries & QA services + FDAimplementation of GMPs + Higher demand for services & for dietary supplement

  13. Slide 13: Market examples of blue-chip strategic investment in natural products

    Market examples of blue-chip strategic investment in the natural products industry .... ®cepsi “The market potential is significant... | believe we are well equipped to deliver authentically nutritious products advantaged by science in an accessible and affordable way fo consumers globally.” 13 -Ind

  14. Slide 14: The Legacy Business provides market intelligence for Proprietary Products

    The Legacy Business provides market intelligence for the identification and development of Proprietary Products LEGACY BUSINESS 14 INTELLECTUAL PROPERTY PROPRIETARY PRODUCTS « Consumer Goods « Patents « Ingredients « Pharmaceuticals Health Claims Supplements « Governments Manufacturing Food & Bevera

  15. Slide 15: pteroPure will be a blockbuster in the field of human health

    pleréPure(ChromaDex-branded pterostilbene) will be a blockbuster in the field of human health a « Pterostilbeneis a phytoalexin (plant defense system) found naturally in blueberries + Apolyphenol similar to resveratrol, it has a 7x longer half-life and10x more bioavailablity ChromaDex has licensed p

  16. Slide 16: Investor kit link

    http://investors.chromadex.com/phoenix.zhtml?c=212121&p=irol-investorKit

  17. Slide 17: pteroPure has significant potential across several market channels

    pleréPure has significant potential across several market channels \17 Dietary Supplements Q3 2010 Food & Beverage Q3 2011 Dietary Supplements Q2 2011 Cosmeceuticals Q4 2012 Beauty & Personal Care Sun Care Q2 2013 pleréPure

  18. Slide 18: pteroPure first brought to dietary supplements and food & beverage markets

    plersPure is first being brought to the dietary supplements and food & beverage markets 18 Dietary Supplements Q3 2010 Food & Beverage Q3 2011 Dietary Supplements. Q2 2011 Cosmeceuticals Q4 2012 Beauty & Personal Care @ ew y Sun Care Q2 2013 plerePure ———_ Pharma 2014

  19. Slide 19: pteroPure | The Ingredient

    pler@Pure | The Ingredient ©

  20. Slide 20: pteroPure awarded Frost & Sullivan's 2010 Most Promising Ingredient of the Year

    plerPure awarded Frost & Sullivan's 2010 “Most |, Promising Ingredient of the Year” NORTH AMERICAN HEALTH INGREDIENTS MOST PROMISING INGREI ‘OF THEYEAR AWARD “An ingredient with proven efficacy and safety that addresses the needs of multi-populations is bound to be successful .... a sustainable prod

  21. Slide 21: Since September 2010, pteroPure adopted by key supplement players

    Since being introduced in September 2010, pleréPure has shown adoption by key players in the supplements market |21 Key customers to date and their respective size Direct to Physician | Internet Direct | ? = [a=] J Company DouglasLabs_ Thome Swanson Life Extension Nutraceutical —Genceutics Int'l Com

  22. Slide 22: pteroPure soon to be incorporated into larger industry players' product lines

    pleréPure is soon to be incorporated into the product line of larger industry players 22 « ChromaDex will shortly announce a significant collaboration with a large private label manufacturer that has distribution strength at major clubs and wholesalers — Costco, Walmart, Sam’s, and BJ’s « This speci

  23. Slide 23: pteroPure poised to enter Food & Beverage after achieving GRAS status

    pleréPure is poised to enter the Food & Beverage | 23 markets after achieving GRAS status Announced GRAS (Generally-Recognized As Safe) status in early June - GRAS self-affirmation complete’ + Seeking letter-of-no-objection from FDA « Filing of dossier to FDA — 3Q 2011 » FDAresponse expected mid-201

  24. Slide 24: pteroPure pursuing qualified health claim status with the FDA

    pleréPure is pursuing qualified health claim status with the FDA to strengthen its market penetration Qualified Health Claim a te : - Allows products containing plerePure to make claims such as “lowers cholesterol” « ChromaDex has an exclusive license to a patent pending on cholestero-lowering effec

  25. Slide 25: Examples of success in the ingredients space

    Examples of success in the ingredients space Qualified Estimated Estimated Company Product GRAS HealthClaim Revenue($M) Market Size($M)' Cargill Corowise Yes Yes 30! 180 (phytosterols) MARTEKC e's DHA life enriched (omega-3) Translates to a $30-$150M opportunity for ChromaDex, but with potentialfor

  26. Slide 26: The foundation for ChromaDex's new retail line

    q {| The foundation for m4 ‘ ple IK) Pp U re : ChromaDex’s new : Retail line ©

  27. Slide 27: pteroPure is the foundation for ChromaDex's retail supplement line

    pleréPure is the foundation for ChromaDex’s 27 retail supplement line... . 85 BlaSciencé The fusion of blueberries and science the fusion of blueberries and science an ombination made possible by _pterostilbene a compound found naturally in blueberries, a line of products that combines the sctive ag

  28. Slide 28: Launch of BluScience now underway at GNC

    Launch of B|U Sciencé now underway at GNC... |28 ° es = Sas BluScience| |BlaScience BluScienceQS EternalBla| |TrimBla Blu2Go aaa plewPure .teostns penPue «tne rece GNC launch: Q3 2011 (2600 corporate stores, up to 2200 franchisees worldwide) "We are extremely excited about the BluScience launch with

  29. Slide 29: BluScience will be supported by an aggressive advertising campaign

    8% tnvoducns. @ BluScience BlaSciencéwill be supported by an aggressive advertising campaign Merts Journal MUSCLESBODY | 29 Google ellbella LIVE WELL EVERY DAY

  30. Slide 30: BluScience will target mass market following the GNC launch

    BlaSciencéwill target mass market following the GNC launch | 30 Whbyreens cvs 8100 stores 7000 Stores 4800 Stores Costco Walmart >!< ==WHOLESALE 420 US. locations Over 3600 U.S. locations ChromaDex will aggressively pursue di ion through mass market retailers

  31. Slide 31: Examples of retail brand success in the dietary supplement market

    Examples of retail brand success in the dietary supplement market 34 Estimated BluScience Category Product Revenue ($M)' equivalent HeartHealth Nature’s Bounty 40 HeartBlu Fish Oil Anti-aging Amerifit DHEA EternalBlu Weight control Alli TrimBlu Energy Stacker Energy Blu2Go Potential opportunity of $

  32. Slide 32: pteroPure also has potential in Beauty & Personal Care and Pharmaceutical markets

    pleréPure also has potential in the Beauty & Personal Care and Pharmaceutical markets 32 Dietary Supplements Q3 2010 » & Ingredients 4 / Food & Beverage Q3 2011 Retailline Dietary Supplements Q2 2011 Cosmeceuticals Q4 2012 Beauty & Personal Care Sun Care Q2 2013 pler@Puré he ©

  33. Slide 33: pteroPure has significant potential as a cosmeceutical

    pleréPure has significant potential as a 33 cosmeceutical due to its topical effects Science Overview Lipophilic structure makes it potentially synergistic with common topical ingredients that effectively cross the skin barrier Research demonstrates the ability to inhibit skin damage & aging effects

  34. Slide 34: Overview of the joint patent with U.C. Irvine on non-melanoma skin cancer

    Overview of the joint patent filed by U.C. Irvine and ChromaDex related to prevention of non- melanoma skin cancer Patent filed jointly between ChromaDex and U.C. Irvine Exposure to UV light activates enzymes (COX-2 and 12-LOX) that damage cellular structure while also inactivating proteins (15-PDGH

  35. Slide 35: Investor kit link

    http://investors.chromadex.com/phoenix.zhtml?c=212121&p=irol-investorKit

  36. Slide 36: Major opportunity for pteroPure in sun care

    This translates into a major opportunity for pleréPure in sun care, particularly in the prevention of non- melanoma skin cancer | 36 Commercial opportunity Currenttopical treatments contain frequent side-effects and have limited efficacy The non-melanoma skin cancer (NMSC) marketis estimated to exce

  37. Slide 37: pteroPure | The Pharmaceutical

    ple IK) Pp U if ny | The Pharmaceutical ©

  38. Slide 38: pteroPure also has significant potential as a pharmaceutical

    pler®Pure also has significant potential as a pharmaceutical 38 Commercial opportunity University of Mississippi study will be the 1% in a series of clinical studies on pathway to pharmaceutical approval - Its effects on lipid and blood sugar levels may be superior to fibrates and provide efficacy w

  39. Slide 39: Pipeline of additional Proprietary Products

    Pipeline of additional Proprietary Products 39 ©

  40. Slide 40: ChromaDex has numerous other proprietary products yet to be marketed

    ChromaDex has numerous other proprietary products yet to be marketed Potential Applications Anthocyanins . Weight-loss . Food pigmentation (C-3-G) . Diabetes » Solarpanelefficiency Otherstilbenoids(e.g. « _Lipidreduction . Cognitive Piceatannol, Trimethoxy) . Oxidative-stress reduction enhancement C

  41. Slide 41: Anthocyanins: ChromaDex's next proprietary product

    Anthocyanins: ChromaDex’s next proprietary product with potential in multiple markets 41 First mover advantage Botanically-derived compounds represent the next ‘super fruit’ class of phytochemical ingredients (natural pigments in purple-colored fruits) « License of process patents obtained from SUNY

  42. Slide 42: Summary

    Summary 42 ©

  43. Slide 43: In review: pteroPure has blockbuster potential across multiple markets

    Inreview.... pleréPure has blockbuster potential | across multiple markets 43 Revenue opportunity ($M) $30—$150M Success across all markets $205M could lead to a $465— $600M opportunity for plersPure Beauty & areleie $80-95M pleréPure a $150M ©

  44. Slide 44: In review: ChromaDex has a focused 3-5 year plan

    Inreview ... ChromaDex has a focused 3-5 year | 44 plan with huge potential upside 709) $Million $505 - 660 600 = Legacy business 500 mu pleréPure 400 The total market opportunity for clersPure could greatly 300 exceed internal plan expectations 200 $100-130 = | 3.5 yr revenue projection 3.5 yr reve

  45. Slide 45: Key milestones for ChromaDex

    Key milestones for ChromaDex Launch, Jer$Pure as a supplementingredient Achieve GRAS Status Launch B |G Science at GNC Launch plersPure as a food & beverage ingredient Launch B | Science into additional mass market retailers Announce human clinical trial results at Univ. of Mississippi Initiate non-

  46. Slide 46: Summary

    Summary 46 « ChromaDex’s legacy business is positioned for growth and provides sourcing for proprietary products ° pleréPure, ChromaDex’s first proprietary ingredient to market, has tremendous growth opportunity across multiple markets « ChromaDex’s growing IP related to other proprietary products p

  47. Slide 47: Contact Information

    Contact Information ChromaDex, Inc. 10005 Muirlands Blvd., Suite G Irvine, CA 92618 Phone: +1-949-419-0288 Fax: +1-949-419-0294 www.chromadex.com 47 ©

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