Slide 1: MRI Interventions Investor Presentation August 2012
MRI INTERVENTIONS ™ Ticker: MRIC Investor Presentation August 2012
Slide 2: Forward-Looking Statements
Forward-Looking Statements Certain matters in this presentation may constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward- looking statements often can be identified by words such as “anti
Slide 3: MRI Interventions, Inc. (MRIC) Opportunity Highlights
MRI Interventions, Inc. (MRIC) Creating MRI-based interventional platforms for the next generation of minimally invasive surgical procedures. OPPORTUNITY HIGHLIGHTS = ClearPoint® Neuro Intervention System, first-to-market platform, allows neurosurgeons to see inside the patient’s brain during a proc
Slide 4: Min. Inv. Procedures: A Revolution Driven by Imaging
Min. Inv. Procedures: A Revolution Driven by Imaging Imaging Modality Resulting Minimally Invasive Platform
Slide 5: Visualization is the Fundamental Building Block
Visualization is the Fundamental Building Block Keystone for min. inv. procedures is intra-procedural visualization. This capability wasn’t available for neurosurgery until ClearPoint. Conventional Procedure ClearPoint Procedure Surgeon sees the outside of Provides detailed visualization, inside the
Slide 6: Support from Clinicians, Industry, and Academics
Support from Clinicians, Industry, and Academics Leading industry partners, academic institutions, and clinicians support MRIC technology and its application across multiple specialties. INDUSTRY PARTNERS CLINICIAN ADVISORS SIEMENS #£BrainLAB Boston, Scientific UNIVERSITY RESEARCH ‘ sf Te sri Dr. Ph
Slide 7: ClearPoint Procedure Overview
ClearPoint Procedure Overview Standard MRI Suite ClearPoint Standard Diagnostic MRI ClearPoint Imaging Coil and Workstation Monitor Scanner Fixation Frame
Slide 8: ClearPoint Procedure Overview
ClearPoint Procedure Overview Target Selection & Entry Plani ENTRY PLANNING ‘ARLES ATER Gn SEG RECA”
Slide 9: ClearPoint Procedure Overview
ClearPoint Procedure Overview SmartFrame® Trajectory Guide | Trajectory Alignment & Device Insertion
Slide 10: ClearPoint Procedure Overview
ClearPoint Procedure Overview ClearPoint: A Breakthrough Platform for Minimally Invasive Neurosurgery .. Now the Neurosurgeon can See
Slide 11: The ClearPoint Difference
The ClearPoint Difference Conventional Procedure ClearPoint Procedure No direct visualization, Direct, high resolution visualization, Performedin an operating room Performedin an MRI Suite Patient often must be awake for their Patient under general anesthesia own brain surgery Long procedures-— up t
Slide 12: ClearPoint Economics
ClearPoint Economics BUSINESS MODEL — RAZOR / RAZORBLADE = ClearPoint Hardware/Software: $180,000 ASP (paid upfrontor over time). ClearPoint Disposables: $7,300 ASP per procedure with strong margins. Generate recurring revenue from the sale of disposables. Procedures covered by existing reimbursemen
Slide 13: Market Opportunity for Minimally Invasive Neurosurgery
Market Opportunity for Minimally Invasive Neurosurgery Addressable Patient Population Therapeutic Approaches Patient Treatment Resistant Deep Brain Direct Focal Indications Population AddressableMarket [J Stimulation Drug Delivery Ablation Parkinson’sDisease 1,500,000 150,000 Today In trials Today E
Slide 14: Additional Benefits of MRI-based Procedures
Additional Benefits of MRI-based Procedures MRI enables visualization of fluids MRI enables visualization of changes in tissue as they are injected into the brain temperature inthe brain MR Thermometry is an MRI-based functionality available on most MR scanner platforms and itisa feature built into
Slide 15: Neurosurgeon Comments on ClearPoint
Neurosurgeon Comments on ClearPoint The ClearPoint System “represents a major step forward in our ability to treat complex neurological diseases.” Dr. Karl Sillay, Director of Adult Functional and Stereotactic Neurological Surgery at the University of Wisconsin, quoted in UW Health News, May 24, 201
Slide 16: ClearPoint Adoption
ClearPoint Adoption CURRENT INSTALLED BASE ——— New Haven ‘Memorial Sloan-Ketering Cancer Center HackensackUMC Whee mace meets eration Uy UNIVERSITY OF UTAH (OQ iteaity Care HEALTHCARED Meth@iist’ The Methodist SS bospital Plus, 2sites in Europe
Slide 17: ClearPoint Market Opportunity
ClearPoint Market Opportunity HIGHLIGHTS BioPortfolio Cutting-Edge Interventional MRI System Transforms Brain Surgery for Parkinson's "= First-to-market in U.S. and Europe Patents Strong support from leading clinicians et ee eS na! NG, INSIDE ns Stimulating the Brain ih 5,000 MRI scanners in U.S. ho
Slide 18: Our Next Platform in Development
Our Next Platform in Development ClearTrace™ Cardiac Intervention System for minimally invasive surgical procedures inthe heart. Intra-procedural Visualization: Current Procedurevs. ClearTrace Current Procedure ClearTrace System 7 CAUTION: tavestigational device. Limited by federal law to lavestigat
Slide 19: Personnel and Infrastructure
Personnel and Infrastructure Research, development, manufacturing, and fulfillment take place in the Company’s facility in Irvine, California PERSONNEL = 20 Employees = 15+ years average med device experience INFRASTRUCTURE = Product development and prototyping performed in-house = Product assembly
Slide 20: Financial Highlights
Financial Highlights BALANCE SHEET HIGHLIGHTS = Cash at July 31 - $5.0M = Shares Outstanding (as of July 31) — 47,402,420 (all common, no pref) = 570M has been invested in MRIC since inception in 1998, primarily R&D INCOME STATEMENT HIGHLIGHTS Six Months Ended 6/30 (in 000s) Revenues 2012 2011 Licen
Slide 21: Financial Highlights
Financial Highlights PUBLIC TRADING COMMENCES = Symbol - MRIC (OTCBB) = $0.75 - Opening Trade May 21, 2012 = $2.50 - Closing Trade on August 17, 2012 = Average Daily Volume — approx. 37,000 (as of Aug 17)
Slide 22: Executing a Simple Growth Strategy
Executing a Simple Growth Strategy GROW SITES = Currently 15 Sites in U.S.; 2 Sites in Europe = Strong and Growing Pipeline GROW UTILIZATION = Utilization Goal: 1 ClearPoint Case/Week = 2 Sites Already at Goal (current run rate) = Example: 15 Sites @ 1 Case/Week = 180 Cases/Qtr HOW WE IMPLEMENT " Hi
Slide 23: MRI Interventions, Inc. (MRIC)
MRI Interventions, Inc. (MRIC) Creating MRI-based interventional platforms for the next generation of minimally invasive surgical procedures. OPPORTUNITY HIGHLIGHTS = ClearPoint® Neuro Intervention System, first-to-market platform, allows neurosurgeons to see inside the patient’s brain during a proc
Slide 24: INTERVENTIONS
INTERVENTIONS a Ticker: MRIC MRI Interventions, Inc. One Commerce Square, Suite 2550 Memphis, TN 38103 (901) 522-9300 info@mriinterventions.com
Slide 25: Descriptions of the Videos Included in this Presentation
Descriptions of the Videos Included in this Presentation This presentation includes five embedded videos. The following table provides the location of each video in the presentation and a description of each video: LL 8 (right side) 9 (right side) 14 15 This video depicts the target selection and en
Slide 26: ClearPoint Neuro Intervention System
ClearPoint Neuro Intervention System ClearPoint Draping in Preparation for a Casein a Diagnostic MRI Suite
Slide 27: ClearPoint Neuro Intervention System
ClearPoint Neuro Intervention System Selected ClearPoint Disposable Components