Kewpie Corporation · TSE:2809
Kewpie — Investor Presentation (February 2012)
20 slides from Kewpie's investor presentation, Feb 24, 2012
Slide 1: Proposal for skincare products using Hyalorepair
Proposal for skincare products using ® 「Hyalorepair 」 【Patent】 international publication number：WO 2011/102462 A1 ＜Brand new hyaluronic acid featuring barrier function recovery＞ Kewpie Corporation Fine Chemical Div. *You are requested to contact us for prior written consent if you wish to transcript
Slide 2: Structure of Hyalorepair
Structure of Hyalorepair ® Adjoined hydrophobic group to hydrophilic HA (hyaluronic acid) This unique HA features barrier function recovery in the skin R R Hydrophobic group introduction by chemical modification through glycerin backbone R：－O－CH2－CH－CH2－O－(CH2)11～12 －CH3 hydrophobic group OH glyceri
Slide 3: Approach to Barrier function recovery
Approach to Barrier function recovery ~Mechanism (including hypothesis)~ Healthy skin Dry skin Repaired skin (formerly dry skin) Stratum corneum Horny cell Lipid layer Hyalorepair® Water layer Lamellar Lipid layer layer “Wedge action” to joint water Water layer layer and lipid layer Lipid layer Horn
Slide 4: Variety of HA and its function
Variety of HA and its function Hyaluronsan HA-LQ HyaloveilⓇ -P Hyalo-OligoⓇ Stratum corneum Retaining moisture by covering Moisturization by the surface of the skin penetrating into the skin HyalorepairⓇ Stratum corneum Dry skin, chapped skin Repairing the skin to normal condition Ⓡ Ⓡ
Slide 5: Proposal: Triple moisturing effects +1
【Proposal】 Triple moisturing effects +1 HA covering the surface of the skin 「Retain Moisture!」 “Hyaluronsan HA-LQ” Adsorptive type HA 「Adsorb and last!」 “HyaloveilⓇ-P” Sebum 皮脂膜 Horny layer 角質層 HA repairing barrier function Epidermis “HyalorepairⓇ” Granular layer 顆粒層 HA penetrating into the skin 「Lo
Slide 6: Functionality test result of Hyalorepair
Functionality test result of ® 「Hyalorepair 」 ＜Brand new hyaluronic acid featuring barrier function recovery ＞ Ⓡ Ⓡ
Slide 7: In Vitro test confirmation of lamella structure formation
Ｉｎ Ｖｉｔｒｏ test confirmation of lamella structure formation 【water only added】 ① Replicate intercellular condition of dry skin Number of Maltese Cross =1 (Average) ② add Hyalorepair® 【Hyalorepair® added】 Number of Maltese Cross =10 (Average) ③ Microscope photographing Lamella structure being confirmed
Slide 8: In vivo test ~ confirmation of effectiveness on damaged skin
In vivo test ~ confirmation of effectiveness on damaged skin ①Water Sample ②1% solution of Hyalorepair® ③1% solution of Sodium Hyaluronate 【Subject】 16 females (aged 20’s～50’s with healthy skin） 【Test method】 Damage the forearm skin with mixed solution of acetone and ether. Test Apply the sample eve
Slide 9: Result ~ Observation by a doctor
【Result】 ~ Observation by a doctor ineffective Water 6％ Effective Slightly effective Very effective 19％ Hyalorepair® 31％ 44％ Effective Very effective 19％ 81％ Slightly effective 18％ Very effective Effective 44％ Applying Hyalorepair® Sodium 38％ improves damaged skin Hyaluronate Ⓡ Ⓡ
Slide 10: Observation of skin condition ~ microscope photographing
【Observation of skin condition】 ~ microscope photographing After damage processing 5 days later (applying everyday) Water Hyalorepair® Improved! Sodium Hyaluronate Ⓡ Ⓡ
Slide 11: Observation of skin condition ~ microscope photographing
No.010 （水） 【 Observation of skin condition】 ~ microscope photographing 【Example of healthy 【Example of damaged Interpretation of the skin condition】 skin condition】 image cristae cutis *Sulci cutis looks powdered because of dryness Sulci cutis *No prominence of cristae cutis confirmed *Stratum corne
Slide 12: Microscope photographing: Hyalorepair
No.012 （ヒアロリペア Microscope ） 【Hyalorepair®】 photographing Before damage 脱脂前processing After damage 脱脂後 processing 1 1day day later 3day later 3 days 5daylater 5 days 30代女性 Ⓡ Ⓡ
Slide 13: Microscope photographing: Water
No.010 （水） Microscope photographing 【Water】 Before damage 脱脂前 processing 脱脂後processing After damage 1day 1 day later 3day 3 days later 5daylater 5 days 30代女性 Subject: female in 30’s Ⓡ Ⓡ
Slide 14: Microscope photographing: HA-LQ Sodium Hyaluronate
No.004 （photographing Microscope ヒアルロンサン HA-LQ 【Sodium ） Hyaluronate】 Before damage 脱脂前processing After damage 脱脂後 processing 1 day later 1day 3day 3 days later 5day 5 days later 30代女性 Ⓡ Ⓡ
Slide 15: Test result: Water content in stratum corneum
【Test result】 Water content in stratum corneum Change rate of water content in stratum corneum 3 days later 250 * p＜0.05 * * 200 150 100 50 Change rate (%) 0 Improvement Water Hyalorepair ﾋｱﾛﾘﾍﾟｱ ® Sodium Hyaluronate ﾋｱﾙﾛﾝｻﾝHA-LQ 1%水溶液 1% solution 1% solution Hyalorepair® improves the moisturization
Slide 16: Test result: Measurement of transepidermal water loss (TEWL)
【Test result】 Measurement of transepidermal water loss （ＴＥＷＬ） Change rate of transepidermal water loss 3 days later 100 * * p＜0.05 80 Improvement 60 40 20 Change rate (%) 0 Water Hyalorepair ﾋｱﾛﾘﾍﾟｱ ® ﾋｱﾙﾛﾝｻﾝHA-LQ Sodium Hyaluronate 1%水溶液 1% solution 1% solution Hyalorepair® prevents skin from water
Slide 17: Hyalorepair Sample formulation
＜Brand new hyaluronic acid featuring barrier function recovery＞ ® 「Hyalorepair 」 Sample formulation （Toner・Emulsion・Gel cream） 【Precaution】 ◆ We do not guarantee the stability, safety, or effectiveness and industrial property right of the finished product formulated with this sample formulation. ◆ A
Slide 18: Sample Formulation: Toner
Sample Formulation 【Toner】 Ingredient （INCI Name） *：Product name Proportion (Wt. ％) １ WATER 87.55 ２ Ethyl Alcohol (ALCOHOL) 4.50 ３ GLYCERIN 3.00 ４ PEG-30 LANOLIN 2.00 ５ BG (BUTYLENE GLYCOL) 2.00 ６ HYALOVEIL®-P* (HYDROXYPROPYLTRIMONIUM 0.30 HYALURONATE) ７ PHENOXYETHANOL 0.20 ８ METHYL PERFLUOROBUTYL E
Slide 19: Sample Formulation: Emulsion
Sample Ingredient （INCI Name） *：Product name Proportion(Wt. ％) １ WATER 80.48 Formulation ２ BG (BUTYLENE GLYCOL) 6.00 【Emulsion】 ３ SQUALANE 3.00 ４ GLYCERIN 2.50 ５ TRIETHYLHEXANOIN 2.00 ６ PHYTOSTERYL/OCTYLDODECYL LAUROYL GLUTAMATE 1.60 ７ MACADAMIA TERNIFOLIA SEED OIL 1.50 ８ POLYGLYCERYL-10 STEARATE 1.
Slide 20: Sample Formulation: Gel cream
Sample Formulation 【Gel cream】 Ingredient （INCI Name） *：Product name Proportion (Wt. ％) 1 WATER 83.14 2 GLYCERIN 5.00 3 BG (BUTYLENE GLYCOL) 5.00 4 SQUALANE 5.00 5 CARBOMER 0.60 6 LUBRAJEL OIL* (PROPYLENE GLYCOL, CARBOMER, GLYCERIN, SODIUM POLYACRYLATE) 0.50 7 HYALOVEIL-P* ® (HYDROXYPROPYLTRIMONIUM