Slide 1: Moderna Digital Investor Event
Moderna Digital Investor Event November 8, 2023 © 2023 Moderna, Inc. All rights reserved.
Slide 2: Forward-looking statements and disclaimer
Forward-looking statements and disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements regarding: the potential advantages of Moderna’s mRNA platform, including probability of techni
Slide 3: Introduction
Introduction Stéphane Bancel CEO © 2023 Moderna, inc. All rights reserved.
Slide 4: mRNA as an information molecule
Digital Event| Introduction Moderna was built on the premise that the natural flow of information in life can be used to develop medicines DNA mRNA Protein C A G A A T G C A G T A A T A U G U A A Storage Software Applications DNA stores instructions for mRNA is a temporary set of Proteins form the b
Slide 5: The promise of mRNA
Digital Event| Introduction The promise of mRNA 1 Large product opportunity 2 Higher probability of technical success 3 Accelerated research and development timelines 4 Greater capital efficiency over time vs. recombinant technology 5 © 2023 Moderna, Inc. All rights reserved.
Slide 6: Moderna's foundational imperatives
Digital Event| Introduction Moderna’s foundational imperatives Obsess over learning rapidly to be Build a platform to enable many medicines the global leader in mRNA science We decided very early to build digital and robotics to enable scale AND speed 6 © 2023 Moderna, Inc. All rights reserved.
Slide 7: AI is driving the next technological revolution
Digital Event| Introduction AI is driving the next technological revolution in the way we work 1980s 2000s Personal computers Smart phones The Internet Artificial intelligence 1990s 2020s 7 © 2023 Moderna, Inc. All rights reserved.
Slide 8: Moderna is well positioned to scale using AI
Digital Event| Introduction Moderna is well positioned to scale using AI We are a We are a platform data-centric company company We are an integrated We are AI ecosystem cloud native 8 © 2023 Moderna, Inc. All rights reserved.
Slide 9: AI is not new to Moderna
& AI Event| Introduction AI is not new to Moderna 2016 2021 ML Platform (Compute) AI Academy (multipurpose algorithm platform) Digital Digital 2016 2023 AI algorithm for INT mChat drug design 2014 2023 Open AI mRNA design (GPT-4) algorithms 9 © 2023 Moderna, Inc. All rights reserved.
Slide 10: Anticipating up to 15 product launches over the next 5 years
Digital Event| Introduction Anticipating up to 15 product launches over the next 5 years Our mRNA platform is delivering across cancer, rare disease, and infectious diseases Respiratory vaccines Latent/other vaccines Oncology Rare disease RSV Seasonal Flu by (older adults) mRNA-1010 mRNA-1345 2025 F
Slide 11: Introduction to Brad Miller
Digital Event| Introduction Introduction to Brad Miller Chief Information Officer, Moderna Previous roles at: 11 © 2023 Moderna, Inc. All rights reserved.
Slide 12: Vision of AI at Moderna
Vision of AI at Moderna Brad Miller Chief Information Officer © 2023 Moderna, inc. All rights reserved.
Slide 13: Embracing AI is key to enhancing workforce value
Introduction AI Vision Embracing AI is key to enhancing workforce value Event| There is a proliferation of digital and AI tools available to disrupt the way we currently work and enable new ways to work Event| Digital Traditional operating models require large Digital workforces as business scale Tr
Slide 14: The impact of digitalization and AI
Digital Event| AI Vision The impact of digitalization and AI Our mission is to deliver the greatest possible impact to people through mRNA medicines. 14 © 2023 Moderna, Inc. All rights reserved.
Slide 15: AI is everywhere at Moderna
Digital Event| AI Vision AI vision: AI is everywhere at Moderna We are building a real-time AI company 15 © 2023 Moderna, Inc. All rights reserved.
Slide 16: The architecture of AI at Moderna
Digital Event| AI Vision The architecture of AI at Moderna mChat Maestro Products Machine Learning Platform Generative AI Build and train models Vectorizations, embeddings… Data Platform Data store, streaming, and discovery Platforms Infrastructure: Integrate technology and large language models 16
Slide 17: The architecture of AI at Moderna
Digital Event| AI Vision The architecture of AI at Moderna mChat Maestro Products Machine Learning Platform Generative AI Build and train models Vectorizations, embeddings… Data Platform Data store, streaming, and discovery Platforms Infrastructure: Integrate technology and large language models 17
Slide 18: Moderna's Large Language Model application: mChat
Digital Event| AI Vision Moderna’s Large Language Model application: mChat Mar 30, 2023 May 8, 2023 August 9, 2023 Why did we need Mar 14, 2023 mChat mChat v1 mChat v1.1 our own application GPT-4 beta (company-wide release) to use GPT-4? • Access to Moderna data • Secure data policy • Expanded capab
Slide 19: Technology alone doesn't drive transformation - people do
Digital Event| AI Vision Technology alone doesn't drive transformation - people do “There’s a rough rule of 30/70, Our AI transformation pillars 30% is tech, 70% is organizational”1 Productize AI with self-service business driven platforms Employee training Data Business integration Generate early s
Slide 20: Agenda
Digital Event| AI Vision Agenda Introduction Stéphane Bancel, Chief Executive Officer Vision of AI at Moderna Brad Miller, Chief Information Officer Data Science Dave Johnson, Chief Data and Artificial Intelligence Officer Brice Challamel, Vice President, Data & AI Transformation, Transformation Gen
Slide 21: Introduction to Dave Johnson
Digital Event| AI Vision Introduction to Dave Johnson Chief Data and Artificial Intelligence Officer, Moderna Previous roles at Moderna: • Vice President, Informatics, Data Science and AI • Senior Director, Informatics • Lead, Automation Integration and Data Analytics 21 © 2023 Moderna, Inc. All rig
Slide 22: Data Science
Data Science Dave Johnson Chief Data and Artificial Intelligence Officer © 2023 Moderna, inc. All rights reserved.
Slide 23: The data science challenge
Digital Event | Data Science The data science challenge Enterprises are struggling to realize the value creation potential of implementing AI 9 out of 10 of tech execs Only 1 in 10 AI believe AI is center of projects make it next tech revolution into production Source: VentureBeat (2019) https://ven
Slide 24: Components of Moderna's early successful AI projects
Digital Event | Data Science Components of Moderna's early successful AI projects Moderna takes a platform approach Data collection Impactful use cases Valuable and actionable use cases that AI can effectively impact the business Research Predictive models Data structuring Application of data Struct
Slide 25: Successful deployment of Machine Learning in research
Digital Event | Data Science Successful deployment of Machine Learning (ML) in research paved the way for Moderna’s integrated AI ecosystem Data collection Development Research Commercial Predictive models Data structuring Manufacturing 25 © 2023 Moderna, Inc. All rights reserved.
Slide 26: AI applications across the value chain
Digital Event | Data Science AI applications across the value chain Assay Patient Supply chain Optimization automation identification simulation of advertising Research Development Manufacturing Commercial Drug design Enrollment Manufacturing Health Authority Queries forecasting optimization (HAQ) a
Slide 27: Informational nature of mRNA technology
Digital Event | Data Science Informational nature of mRNA technology lends itself to design and optimization algorithms mRNA Formulated LNP Protein …UCUAGA… … Gly Val Cys Glu Gln … © 2023 Moderna, Inc. All rights reserved.
Slide 28: Using AI for mRNA drug design
Digital Event | Data Science Using AI for mRNA drug design Challenges Goal • Design space is vast Design or optimization mRNA, protein, and – Proteins: 20^(sequence length) LNP components with desired properties: – mRNA: (codon choices)^(sequence length) • Reduced toxicity – Chemistry: 1060 or more
Slide 29: AI interfaces for drug design
Digital Event | Data Science AI interfaces for drug design mRNA mRNA Protein Backtranslation Design Generation IBM Chemical IBM Quantum DNA Template Generation Computing Design Antibody MHC Affinity Rapid Formulation Humanization Prediction Design 29 © 2023 Moderna, Inc. All rights reserved.
Slide 30: Individualized neoantigen therapy use case
Digital Event | Data Science Individualized neoantigen therapy (INT) use case Assay Patient Supply chain Optimization automation identification simulation of advertising Research Development Manufacturing Commercial Drug design Enrollment Manufacturing Health Authority Queries forecasting optimizati
Slide 31: mRNA-4157 (V940): An Individualized Neoantigen Therapy
Digital Event | Data Science mRNA-4157 (V940): An Individualized Neoantigen Therapy (INT) Our individualized neoantigen therapy is designed to target an individual patient’s unique tumor mutations and encodes up to 34 neoantigens DNA-Seq, DNA sequencing: HLA, human leukocyte antigen; mRNA, messenger
Slide 32: INT drug design algorithm
Digital Event | Data Science INT drug design algorithm Our individualized neoantigen therapy is designed to target an individual patient’s unique tumor mutations and encodes up to 34 neoantigens NGS Neoantigen Annotate mRNA-4157 (V940) sequencing selection neoantigen reading frame algorithm features
Slide 33: Impactful use case: Integrated INT manufacture scheduling
Digital Event | Data Science Impactful use case: Integrated INT manufacture scheduling Objective Solution • Create an infrastructure that enables every • An integrated end-to-end solution to mRNA-4157 (V940) patient to receive their enable the best site and patient initial administration of INT with
Slide 34: Link to webcast to view video presentation
Digital Event | Data Science Link to webcast to view video presentation 34 © 2023 Moderna, Inc. All rights reserved.
Slide 35: New products leveraging Moderna's AI architecture
Digital Event | Data Science New products leveraging Moderna’s AI architecture Competitive intelligence Toxicology reports PV narratives Clinical trials QA analytics for SOPs Customer 360 Employee engagement RegBot 35 © 2023 Moderna, Inc. All rights reserved.
Slide 36: The architecture of AI at Moderna
Digital Event | Data Science The architecture of AI at Moderna mChat Competitive intelligence Toxicology reports PV narratives Maestro Clinical trials QA analytics for SOPs Customer 360 Employee engagement RegBot Products Machine Learning Platform Generative AI Build and train models Vectorizations,
Slide 37: Introduction to Brice Challamel
Digital Event | Transformation Introduction to Brice Challamel Vice President, Data & AI Transformation, Generative AI Previous roles at: 37 © 2023 Moderna, Inc. All rights reserved.
Slide 38: AI Transformation
AI Transformation Brice Challamel VP, Data & AI Transformation, Generative AI © 2023 Moderna, inc. All rights reserved.
Slide 39: Successful AI implementation relies on enhancing data science
Digital Event | Transformation Successful AI implementation relies on enhancing data science and driving organizational transformation “There’s a rough rule of 30/70, 30% is tech, 70% is organizational”1 Our AI transformation pillars - Karim Lakhani, HBS Productize AI with self-service business driv
Slide 40: Successful AI implementation relies on enhancing data science
Digital Event | Transformation Successful AI implementation relies on enhancing data science and driving organizational transformation Our AI transformation pillars Instruction accelerates transformation Productize AI with self-service business driven platforms Generate early success symbols in ever
Slide 41: Empower users and managers with our AI academy
Digital Event | Transformation Empower users and managers with our AI academy Our AI academy is designed to transform Moderna into a real-time AI organization Executive committee 1:1 sessions Creating a strategic AI for senior vision leadership Identifying GACT1 Teamwork business value Capstone Empo
Slide 42: Creating customized technology tools
Digital Event | Transformation Creating customized technology tools mChat introduces Moderna employees to Gen AI Progressive data Expanded mChat Introducing a Data Analytics policy, from a Capabilities with Simplified Interface and Proficiency safer data Document Upload for Easier Use Tracking ecosy
Slide 43: Creating customized technology tools
Digital Event | Transformation Creating customized technology tools mChat introduces Moderna employees to Gen AI Progressive data Expanded mChat Introducing a Data Analytics policy, from a Capabilities with Simplified Interface and Proficiency safer data Document Upload for Easier Use Tracking ecosy
Slide 44: Leveraging AI to create easy-to-implement, personalized products
Digital Event | Transformation Leveraging AI to create easy-to-implement, personalized products Built by Everyone as a self- Built by Built by ML & GenAI Built by your assigned PM & service capability. Advanced Users. Engineering Team. DBR, with CVM prioritization 1- Superprompts 2- Custom Workflows
Slide 45: Leveraging AI to create easy-to-implement, personalized products
Digital Event | Transformation Leveraging AI to create easy-to-implement, personalized products Built by Everyone as a self- Built by Built by ML & GenAI Built by your assigned PM & service capability. Advanced Users. Engineering Team. DBR, with CVM prioritization 1- Superprompts 2- Custom Workflows
Slide 46: Leveraging AI to create easy-to-implement, personalized products
Digital Event | Transformation Leveraging AI to create easy-to-implement, personalized products Built by Everyone as a self- Built by Built by ML & GenAI Built by your assigned PM & service capability. Advanced Users. Engineering Team. DBR, with CVM prioritization 1- Superprompts 2- Custom Workflows
Slide 47: Leveraging AI to create easy-to-implement, personalized products
Digital Event | Transformation Leveraging AI to create easy-to-implement, personalized products Built by Everyone as a self- Built by Built by ML & GenAI Built by your assigned PM & service capability. Advanced Users. Engineering Team. DBR, with CVM prioritization 1- Superprompts 2- Custom Workflows
Slide 48: Leveraging AI to create easy-to-implement, personalized products
Digital Event | Transformation Leveraging AI to create easy-to-implement, personalized products Built by Everyone as a self- Built by Built by ML & GenAI Built by your assigned PM & service capability. Advanced Users. Engineering Team. DBR, with CVM prioritization 1- Superprompts 2- Custom Workflows
Slide 49: Building and maintaining an AI culture
Digital & AI Event | Transformation Building and maintaining an AI culture Training sessions for employees Functional workshops with expert speakers Periodic training sessions and workshops facilitate company-wide AI adoption and culture 49 © 2023 Moderna, Inc. All rights reserved.
Slide 50: AI is being adopted across work functions
Digital Event | Transformation AI is being adopted across work functions 120% R&D 100% Tech Dev % of team using mChat Legal 80% HR % of team using mCgat 60% Finance Digital 40% Commercial 20% Brand Each bubble represents a team 0% within the business division -100 0 100 200 300 400 500 600 Bubble si
Slide 51: Conclusion
Conclusion Brad Miller Chief Information Officer © 2023 Moderna, inc. All rights reserved.
Slide 52: Democratizing AI transforms how people are working
Digital Event| Conclusion Democratizing AI transforms how people are working AI User Enabling people to create value measured in efficacy (do better) and efficiency (do more) at the center of our operating model AI Business Powered by AI technology, business owners/leaders create AI products to meet
Slide 53: AI use case portfolio
Digital Event| Conclusion 5 5 4 is expanding… AI use case portfolio 4 3 3 2 2 1 1 000 000 1 machine learning (ML) use cases added 9 9 large language model (LLM) use 2 1 1 cases added 3 2 2 4 3 3 53 © 2023 Moderna, Inc. All rights reserved.
Slide 54: AI use case portfolio
Digital Event| Conclusion 5 5 4 is expanding… AI use case portfolio 4 3 3 2 2 1 1 999 999 1added 1 machine learning (ML) use cases 1(LLM) use1 large language model 2 2 2 2 cases added 3 3 3 3 4 4 4 4 54 © 2023 Moderna, Inc. All rights reserved.
Slide 55: AI use case portfolio
Digital Event| Conclusion 5 8 5 3 6 6is expanding… AI use case portfolio 6 6 7 7 7 7 8 8 8 8 8 6 7 9 9 9 9…and is growing daily999 1 machine learning (ML) use added cases 1 large language model (LLM) use 2 2 cases added 3 3 4 4 55 © 2023 Moderna, Inc. All rights reserved.
Slide 56: Moderna's integrated AI ecosystem is generating many use cases daily
Digital Event| Conclusion Moderna’s integrated AI ecosystem is generating many use cases daily across functions AI-driven impact Commercial Drive ’24 sales with smaller sales force Manufacturing Automate operations, reduce COGS, unlock process innovation Research & Development Accelerate research an
Slide 57: The impact of digitalization and AI
Digital Event| Conclusion The impact of digitalization and AI 57 © 2023 Moderna, Inc. All rights reserved.
Slide 58: We are building a real-time AI company
Digital Event| Conclusion We are building a real-time AI company To DELIVER the greatest possible impact to PEOPLE through mRNA MEDICINES 58 © 2023 Moderna, Inc. All rights reserved.
Slide 59: Anticipating up to 15 product launches over the next 5 years
Digital Event| Conclusion Anticipating up to 15 product launches over the next 5 years Our mRNA platform is delivering across cancer, rare disease, and infectious diseases Respiratory vaccines Latent/other vaccines Oncology Rare disease RSV Seasonal Flu by (older adults) mRNA-1010 mRNA-1345 2025 Flu
Slide 60: Q&A
Q&A © 2023 Moderna, Inc. All rights reserved.