Agilent Technologies, Inc. · NYSE:A
Agilent Technologies — Technical Presentation (2013)
54 slides from Agilent Technologies's technical presentation, 2013
Slide 1: Lower Operating Costs, Safer Operation, More Productive
Lower Operating Costs, Safer Operation, More Productive. Agilent 4100 MP-AES Steve Wall, Agilent Technologies
Slide 2: Common Challenges facing Laboratories doing Elemental Analysis Today
Common Challenges facing Laboratories doing Elemental Analysis Today • Increased need for multi-element determination over a wide dynamic range • Desire to reduce the overall cost of analysis due to rising costs (instrument supplies and consumables; power; labour etc) • Difficulty in sourcing some g
Slide 3: Agilent 4100 Microwave Plasma-Atomic Emission Spectrometer (MP-AES)
Agilent 4100 Microwave Plasma-Atomic Emission Spectrometer (MP-AES) New technique for elemental determination using atomic emission • Microwave excited plasma source • Nitrogen based plasma - runs on air (using a N2 generator) Improved performance compared with flame AA: • Higher sample throughput w
Slide 4: Schematic Diagram
Schematic Diagram 2 1 10 1. Instrument exhaust 2. Pre-optics window 12 3. Torch loader 4. Peristaltic pump 11 5. Plasma enable button 6. High voltage power supply 7. Electronics (control PWB) 8. Pre-optics 9. Plasma (Magnetron) 10. Monochromator with CCD detector 11. External gas control module 6 12
Slide 5: Microwave Plasma Emission Overview
Microwave Plasma Emission Overview EXCITATION Ground State Excited State Relaxation Emission Monochromator Quantitation & Detector Atom Formation Microwave excited Plasma Sample Page 5
Slide 6: How Does MP-AES Work?
How Does MP-AES Work? Agilent’s patented microwave waveguide technology • Using nitrogen as the plasma gas gives a robust plasma with a conventional torch. Nitrogen can be supplied either via bottled gas or via nitrogen generator • Magnetic excitation gives a toroidal plasma and an effective central
Slide 7: Performance – Typical Detection Limits
Performance – Typical Detection Limits DL’s in ppb, clean water samples Element Flame AA MP-AES Element Flame AA MP-AES K 0.8 0.65 As* 60 45 Ca 0.4 0.05 Cd 1.5 1.4 Mg 0.3 0.12 Cr 5 0.5 Na 0.3 0.12 Mn 1.0 0.25 Au 5 1.8 Pb 14 4.4 Pt 76 4.5 Sb 37 12 Pd 15 3.8 Se* 500 70 Ag 1.7 0.5 V 20 0.2 Rh 4 0.5 * 3
Slide 8: Performance – Extended Working Range
Performance – Extended Working Range MP - normal AA range MP - Extended Range
Slide 9: Reduced Cost of Ownership
Reduced Cost of Ownership Cost savings based on reductions in gas expenses ONLY!. Assumes measuring 9 elements (4 nitrous-oxide elements) in batches of 100 samples, 3 days/week using the N2 generator. For a detailed cost comparison, consult your local Agilent representative Page 9
Slide 10: Simple Torch Installation – No Alignment
Simple Torch Installation – No Alignment Page 10
Slide 11: New Generation MP Expert Software
New Generation MP Expert Software • Windows 7, worksheet based software with significant enhancements • Fresh, clean look • Provides capability for: • Applet style operation using preset methods, or • Access to full capabilities • Automated optimization tools • Innovative and simple to use backgroun
Slide 12: New Generation MP Expert Software
New Generation MP Expert Software • Retains familiar “worksheet” based approach Spectra Results matrix Calibration Replicate data Page 12
Slide 13: Applet Style Operation using MP Expert Software
Applet Style Operation using MP Expert Software • Simplified software operation for operators Page 13
Slide 14: Accessory Options for the 4100 MP-AES
Accessory Options for the 4100 MP-AES • Automate and simplify analysis with the SPS3 autosampler (required for unattended overnight operation) • For organic applications, use the EGCM to bleed air into the plasma minimizing C build-up and reducing background – also requires the OneNeb inert nebulize
Slide 15: Applications for the Agilent 4100 MP-AES
Applications for the Agilent 4100 MP-AES Geochemistry, Mining Chemical and Petrochemical and Minerals Food and Agriculture Environmental
Slide 16: Applications MP-AES Can Do – by Market
Applications MP-AES Can Do – by Market Still the leader in Xenon flash lamp technology after 12 years! Page 16
Slide 17: Geochemical, Metals and Mining Applications
Applications for the Geochemical, Metals and Agilent 4100 MP-AES Mining Applications
Slide 18: Mining (Geochemistry) Applications
Mining (Geochemistry) Applications Aqua regia digests, fire assay, cyanide leaches • Au, Ag, Pt, Pd, Cu, Ni, Zn Analytical Challenges • Low detection limits • High levels of dissolved solids • Linearity • Sample throughput Page 18
Slide 19: Gold and Precious Metals by Fire Assay
Gold and Precious Metals by Fire Assay Au, Pt and Pb extracted into a silver sphere Fire Dissolve Dry and Assay in 4mL Crush Process 25% AR Page 19
Slide 20: Instrument Parameters
Instrument Parameters Parameter Setting Nebulizer Glass concentric Spray chamber Single-pass glass cyclonic Read Time 3s Replicates 3 Sample uptake delay 10 s Stabilization time 5s Fast Pump On (80 rpm) Background correction Auto Nebulizer Pressure 140 to 240 kPa (auto optimized) Page 20
Slide 21: Extended Linear Range for Platinum & Palladium
Extended Linear Range for Platinum & Palladium Both Pt & Pd linear to 120 ppm Analyte Correlation Pt 265.495 0.9999 Pd 363.470 0.9995 Page 21
Slide 22: Accuracy – Platinum & Palladium in Custom CRMs
Accuracy –Platinum & Palladium in Custom CRMs Platinum CRM Certified value (mg/L) MP-AES result (mg/L) 6 0.74 0.75 7 35.6 35.9 8 9.0 9.5 Palladium CRM Certified value (mg/L) MP-AES result (mg/L) 6 3.21 3.4 7 44.4 44.0 8 35.0 36.5 Page 22
Slide 23: Superior Performance – Detection Limits
Superior Performance – Detection Limits Analyte Wavelength (nm) Method Flame AA DL (ug/L) IDL (ug/L) Au 267.595 4 11 Pt 265.945 13 76 Pd 363.469 0.7 15 MDL = 3σ, 3s read time, 20 blanks Page 23
Slide 24: MP-AES Improves Throughput over Flame AA
MP-AES Improves Throughput over Flame AA Ore analysis can be volume limited Typical sample volume available ~4mL Automate analysis & reduce sample consumption using the autosampler • Analysis time only 55s sample to sample • Sample consumption ~1.8 mL • Throughput 65 samples/hour, or 520 samples in
Slide 25: Chemical and Petrochemical Applications
Applications for the Chemical and Petrochemical Agilent 4100 MP-AES Applications
Slide 26: Applications MP-AES Can Do – by Market
Applications MP-AES Can Do – by Market Still the leader in Xenon flash lamp technology after 12 years! Page 26
Slide 27: Organic Applications – The Challenge
Organic Applications – The Challenge High vapour • Plasma instability pressure from • May extinguish the plasma solvents • Poor precision and drift Carbon build up in • Down time - injector may require injector regular cleaning • Poor precision Nebulizer • Down time - nebulizer needs blockage cleani
Slide 28: Organics Kit - External Gas Control Module (EGCM)
Organics Kit - External Gas Control Module (EGCM) 1. Prevents carbon build up on the injector when running organics 2. Reduces the background emissions from the plasma 3. A controlled flow of air is bled into the Auxiliary gas flow through the torch Page 28
Slide 29: Determination of Impurities in Gasoline and Petro-Diesel Fuels
Determination of Impurities in Gasoline and Petro-Diesel Fuels Page 29
Slide 30: Limits on Target Elements in Diesel Fuel - EN14538
Limits on Target Elements in Diesel Fuel - EN14538 Page 30
Slide 31: Sample Preparation – Method EN14538
Sample Preparation – Method EN14538 A commercial diesel sample was analysed • 1:10 dilution with Shellsol Standards made from Conostan S21+K • 0.5 ppm, 1 ppm, 5 ppm, 10 ppm All samples and standards matrix matched with blank oil Page 31
Slide 32: Instrument Parameters
Instrument Parameters Parameter Setting Nebulizer Inert OneNeb Spray chamber Double-pass glass cyclonic Sample tubing Orange/green solvent resistant Waste tubing Blue/blue solvent resistant Read Time 3s Replicates 3 Stabilization time 15 s Fast Pump (80 rpm) On Background correction Auto Pump speed
Slide 33: Method Detection Limits
Method Detection Limits 3σ, 3s read time, 10 blanks Element Wavelength (nm) MDL (ppb) Mg 285.213 2.7 Ca 422.673 8.2 Na 588.995 18.7 K 766.491 2.7 Page 33
Slide 34: Spike Recoveries on Diesel Fuel
Spike Recoveries on Diesel Fuel Diesel fuel sample spiked with 0.55 ppm S21+K Element Sample Spiked Recovery (%) (ppm) Sample (ppm) Mg 285.213 nm < MDL 0.53 97 Ca 422.673 nm < MDL 0.51 93 Na 588.995 nm < MDL 0.51 93 K 766.491 nm < MDL 0.51 93 Page 34
Slide 35: Food and Agricultural Applications
Applications for the Food and Agricultural Agilent 4100 MP-AES Applications
Slide 36: Applications the MP-AES can do – by Market
Applications the MP-AES can do – by Market Still the leader in Xenon flash lamp technology after 12 years! Page 36
Slide 37: Food Applications – Types of Measurement
Food Applications – Types of Measurement Product Food Quality Food Research Labeling • Contamination Production • Developing • Nutrient Levels • Pollutants • QA/QC Better Products Page 37
Slide 38: Which Elements are Monitored in Foods?
Which Elements are Monitored in Foods? Toxic trace elements • Low level analysis – typically ppb levels • As, Cd, Hg, Pb, Tl, Cr Common elements that are toxic in excess • Typically range from ppb to ppm level • Al, Ni, Cu, Zn, Se, Mo, Sn Essential minerals • Can cover a wide range from ppm to % lev
Slide 39: Sample Types
Sample Types Wide Range of Matrices • Dairy, Meat, Fish, Grain, Vegetables, Fruit, etc • Processed goods • Canned, frozen, dried and preserved food • Drinks (soda, tea, coffee, alcoholic beverages etc.) • Preservatives, “fillers” and additives such as calcium carbonate • “Nutraceuticals” Other Impor
Slide 40: Food and Agriculture Applications – The Challenge
Food and Agriculture Applications – The Challenge • Large number of samples Robust Sample • Wide range of matrices Introduction • High total dissolved solids (TDS) • Potential for spectral interferences Many Elements • Labs. need high sample throughput Per Sample • Labs. also want low cost of analys
Slide 41: Major, Minor and Trace Analysis in Foodstuffs
Major, Minor and Trace Analysis in Foodstuffs A range of samples 1. NIES CRM No.7 Tea Leaves 2. NIES CRM No.10c Rice Flour 3. NIST SRM 1577 Bovine Liver: Plus pre-prepared sample solutions in 4 % HNO3 (High Purity Standards) 4. CRM-Wheat Flour 5. CRM-Milk Powder 6. CRM-Oyster Tissue Page 41
Slide 42: Instrument Parameters
Instrument Parameters Parameter Setting Nebulizer Glass concentric Spray chamber Single pass glass cyclonic Sample tubing White/white Waste tubing Blue/blue Read Time 10 s Replicates 3 Stabilization time 10 s Fast Pump On (80 rpm) Pump speed 12 rpm Nebulizer pressure 160 – 180 kpa (auto optimized) B
Slide 43: Measured Results for CRM Food Samples
Measured Results for CRM Food Samples NIES No. 7 Tea Leaves High Purity Stds CRM Milk Powder * Reference values only Page 43
Slide 44: Measured Results for CRM Food Samples
Measured Results for CRM Food Samples NIES No. 10c Rice Flour High Purity Stds CRM Wheat Flour * Reference values only Page 44
Slide 45: Measured Results for CRM Food Samples
Measured Results for CRM Food Samples NIST 1577 Bovine Liver High Purity Stds CRM Oyster Tissue * Reference values only Page 45
Slide 46: Applications the MP-AES can do – by Market
Applications the MP-AES can do – by Market Still the leader in Xenon flash lamp technology after 12 years! Page 46
Slide 47: Instrument Parameters
Instrument Parameters Parameter Setting Nebulizer Glass concentric Spray chamber Single pass glass cyclonic Sample tubing Black/black Waste tubing Blue/blue Read Time 3s Replicates 3 Stabilization time 10 s Fast Pump (80 rpm) On Pump speed 15 rpm Viewing position -20 to 20 steps (auto optimized) Neb
Slide 48: Measured Results for NIST SRM 2710 Montana Soil
Measured Results for NIST SRM 2710 Montana Soil Analyte MP-AES Results NIST Reference Average (mg/kg) Range (mg/kg) Al 24300 ± 400 12000 - 26000 As 550 ± 20 490 - 600 Cr 21 ± 1 15 - 23 Cu 2800 ± 20 2400 - 3400 Fe 28000 ± 300 22000 - 32000 Mn 8500 ± 200 6200 - 9000 Ni 9.5 ± 0.6 8.8 - 15 Pb 5600 ± 300
Slide 49: Measured Results for NIST SRM 2711 Montana Soil
Measured Results for NIST SRM 2711 Montana Soil Analyte MP-AES Results NIST Reference Average (mg/kg) Range (mg/kg) Al 20000 ± 200 12000 - 23000 As 90 ± 15 88 - 110 Cr 21 ± 3 15 - 25 Cu 90 ± 1 91 - 110 Fe 23000 ± 2000 17000 - 26000 Mn 600 ± 10 400 - 620 Ni 17 ± 3 14 - 20 Pb 1400 ± 30 930 - 1500 Zn 3
Slide 50: Improving Detection Limits for As, Se, Hg with MSIS
Improving Detection Limits for As, Se, Hg with MSIS Analyte MSIS in Simultaneous Mode ug/L As 1.0 Se 2.0 Hg 0.5 Page 50
Slide 51: Application Notes Available
Application Notes Available Geochemical • New methodology for analysis of gold and precious metals • Analysis of base metals in geochemical samples Chemical & Petrochemical • Analysis of wear metals and contaminants in engine oils • Analysis of lubricating oil additives • Analysis of trace elements
Slide 52: Agilent 4100 MP-AES
Agilent 4100 MP-AES Runs on air – the most significant advance in atomic spectroscopy o Lowest running cost of any atomic spectroscopy technique due to capability to run on air – ideal for remote and at site operation o Improved safety – capability to run on air means no flammable gases and no manua
Slide 53: Agilent's Atomic Spectroscopy Portfolio
Agilent’s Atomic Spectroscopy Portfolio ICP-OES ICP-MS ICP-QQQ Flame AAS Graphite Furnace AAS 4100 MP-AES AAS instruments can be flame only, furnace only, or combined (switchable) Page 53
Slide 54: Questions?
QUESTIONS? The Measure] of Confidence . Agilent Technologies Page 54