Uscom Limited · ASX:UCM
Uscom — Investor Presentation (April 2014)
28 slides from Uscom's investor presentation, April 2014
Slide 1: USCOM: Hemodynamics Fluid Innovation
USCOM 1A Hemodynamics Fluid Innovation www.uscom.com.au The Measure of Life
Slide 2: What is USCOM?
What is USCOM? Totally Noninvasive Monitor for Individualized Hemodynamic Management • Identify illness • Predict fluid responsiveness • Trend therapy response • Improve outcome Clinical Gold Standard www.uscom.com.au The Measure of Life
Slide 3: Why USCOM?
Why USCOM? Totally Noninvasive, Safe, Portable, Fast • Identify illness • Clarify hemodynamic status • Predict fluid responsiveness • SVI & SMII / SVV / FTc / PLR • Trend therapy response • Direct appropriate treatment • Improve outcome • Individual Optimization www.uscom.com.au The Measure of Life
Slide 4: Individualize Resuscitation
Individualize Resuscitation • Stroke Volume Index • Sensitive and responsive to circulatory change • SMII (Unique to USCOM) • Safe, one-step fluid responsiveness • Distinguish low inotropy from low preload • Rapid optimization of fluid management and drug titration www.uscom.com.au The Measure of Li
Slide 5: SMII – Preload and Afterload Independent
SMII – Preload and Afterload Independent SV and SMII after 5ml/Kg Rapid IV Fluid Infusion Between measures 6 and 7 a completely stable and unstimulated patient with an implanted pacemaker and a fixed heart rate of 60 per minute was given 5ml/kg of fluid over a 10 minute period. All other readings we
Slide 6: Fluid Responsiveness Predictive
Fluid Responsiveness Predictive www.uscom.com.au The Measure of Life
Slide 7: Low SVI, Low Inotropy
Low SVI, Low Inotropy X SMII 0.8 • Negative fluid responsiveness: SVI < 35 ml/m2 & SMII < 1.1 W/m2 www.uscom.com.au The Measure of Life
Slide 8: Individualize Optimization
Individualize Optimization • Predict safe fluid responsiveness • Guide and manage therapy Fluid Diuretic Inotrope Vaso +ve Dilator -ve Constrictor The Frank-Starling curve www.uscom.com.au The Measure of Life
Slide 9: Monitoring Features
Monitoring Features • One modality, one position • CW Doppler at Aortic or Pulmonary Valve • LVOT diameter anthropometric algorithm • Improves reproducibility and sensitivity • Option to override with echo measure • Multiple beats per measure automatically traced • Improves sensitivity • All traced
Slide 10: Monitoring Features
Monitoring Features • Beat to beat hemodynamic parameters: SV, CO, SVR,* SMII,* FTc, SVV, DO2* • Numerical or graphical display • SVV for fluid responsiveness • Traced beats of one or two full respiratory cycles • SMII systolic power of the heart • Preload and afterload independent. • High correlati
Slide 11: How USCOM Works
How USCOM Works Click image to play movie http://youtu.be/ZOUr8WOfxrc www.uscom.com.au The Measure of Life
Slide 12: CW Doppler Ultrasound
CW Doppler Ultrasound • Accurate • Reproducible • Sensitive • Safe Measures blood velocity and volume www.uscom.com.au The Measure of Life
Slide 13: Flow Area
Flow Area • Flow area (OTD) determined by Algorithm • Linear relationship with Height • Neonates (<50cm/20ins) Weight Height → Area www.uscom.com.au The Measure of Life
Slide 14: Calculating Flow
Calculating Flow Stroke Volume = Valve area x Stroke distance Diameter Stroke Distance (OTD) (vti) Cardiac Output = Stroke Volume x Heart Rate www.uscom.com.au The Measure of Life
Slide 15: DO2 – Oxygen Delivery
DO2 – Oxygen Delivery • Manipulation of preload, afterload CI are and inotropy the means of optimizing perfusion Inotrop y www.uscom.com.au The Measure of Life
Slide 16: Parameters of DO2
Parameters of DO2 • Circulation Cardiac Output (CO) • Preload Stroke Volume (SV) Stroke Volume Variation (SVV) Flow Time corrected (FTc) • Inotropy Inotropy Index (SMII) • Afterload Systemic Vascular Resistance (SVR) • Perfusion Oxygen Delivery (DO2) www.uscom.com.au The Measure of Lif
Slide 17: Monitor with USCOM
Monitor with USCOM Parameters are measured All parameters and data are real time, beat-to-beat trended and stored www.uscom.com.au The Measure of Life
Slide 18: Clinical Units
Clinical Units • Pediatric ICU • Obstetric Medicine • Hemodialysis • Neonatal ICU • Rapid Response • Drug trials • Adult ICU • Liver Transplantation • Animal research • Emergency • Step Down Unit • Electrophysiology • Anesthesiology • Cardiology • Sports Medicine • Oncology • Burns Unit • Veterinary
Slide 19: Clinical Applications
Clinical Applications • Fluid • Hypertension Responsiveness • Heart Failure • Fluid Status • Vasoconstriction • Systolic Function • Vasotherapy • Sepsis • Arrhythmias • Shock • Hypotension www.uscom.com.au The Measure of Life
Slide 20: Clinical Value
Clinical Value • Improve Care • Reduce Risk • Reduce Cost www.uscom.com.au The Measure of Life
Slide 21: Improve Care
Improve Care • Know the hemodynamic state • Accurate & sensitive • Direct appropriate therapy • Rational & Individual • Understand the effect of treatment • Trend change www.uscom.com.au The Measure of Life
Slide 22: Reduce Risk
Reduce Risk • First do no harm • Safer alternative to invasive and semi invasive • Avoid complications • Totally NON invasive • Deliver the right drug at the right time • Individualized management www.uscom.com.au The Measure of Life
Slide 23: Reduce Cost
Reduce Cost • Avoid operating costs • No consumables • Assess and intervene early • Portable, fast and easy to learn and use • Maximize investment • Multiple patient management www.uscom.com.au The Measure of Life
Slide 24: Validation
Validation • Historical validation of CW Doppler • Flowprobes in hemodynamic models & animals • Pulmonary artery catheter in animals and post cardiac surgical/heart failure • PiCCO / Pulmonary artery catheter in critically ill patients on vasotherapy and ventilated • Echo / MRI in clinical studies w
Slide 25: Clinical Evidence
Clinical Evidence • Fluid Optimization – “The change in SV with PLR was the only hemodynamic index with significant predictive ability” • Pediatric Sepsis – “Subsequent ICU hemodynamic support directed to goals of …… cardiac index of 3.3-6.6l/min/m2” • “The evolving haemodynamics of paediatric septi
Slide 26: USCOM
USCOM Totally Noninvasive Monitor for Individualized Hemodynamic Management • Identify illness • Predict fluid responsiveness • Trend therapy response • Improve outcome NEW Clinical Gold Standard www.uscom.com.au The Measure of Life
Slide 27: USCOM Advantages
USCOM Advantages Individualized Hemodynamic Management • Noninvasive and Reliable • Accurate and Validated • Adults, Children & Neonates • Critically ill and Well Patient • Hospital wide • Fast, Portable & Safe • Highly Economical www.uscom.com.au The Measure of Life
Slide 28: The Measure of Life
The Measure of Life www.uscom.com.au Uscom © 2013 - Revision 0002 The Measure of Life