Sana Biotechnology, Inc. · NASDAQ:SANA
Sana Biotechnology — Investor Presentation (December 2023)
28 slides from Sana Biotechnology's investor presentation, Dec 11, 2023
Slide 1: Corporate Presentation December 2023
Corporate Presentation December 2023 Exhibit 99.1
Slide 2: Cautionary Note Regarding Forward-Looking Statements
This presentation contains forward-looking statements about Sana Biotechnology, Inc. (the “Company,” “we,” “us,” or “our”) within the meaning of the federal securities laws. All statements other than statements of historical facts contained in this presentation, including, among others, statements r
Slide 3: Engineered Cells as Medicines
Sana’s ambition is to repair or replace any cell in the body. Technologies address fundamental barriers: Hypoimmune (HIP) technology: Overcoming immune rejection of allogeneic cells Fusogen technology: In vivo delivery of genomic modification reagents in a cell-specific manner Overcoming immune reje
Slide 4: Pipeline poised to deliver multiple clinical data readouts over next several years
Pipeline poised to deliver multiple clinical data readouts over next several years Sana’s ex vivo cell engineering technology 1Investigator sponsored trial. Abbreviations: AAV, ANCA-associated vasculitis; AD, autoimmune disease; ALL, acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; C
Slide 5: Overcoming allogeneic immune rejection has been key limitation in transplant and cellular medicine
~75 years of organ and bone marrow transplants – immune rejection remains the largest problem Cell-based medicines face similar immune rejection challenges Significant immunosuppression is current standard Genome modification efforts to date have generally been incomplete Autologous therapies have l
Slide 6: Sana's hypoimmune solution: Leverage insights from nature
Sana’s hypoimmune solution: Leverage insights from nature Abbreviations: MHC, major histocompatibility complex. Current clinical platform with multiple ongoing approaches in research phase. Leverage insights from nature to create hypoimmune cells Sana’s hypoimmune approach + CD47 - MHC I - MHC II He
Slide 7: Sana's team has pioneered hypoimmune technology
Sana’s team has pioneered hypoimmune technology
Slide 8: Hematologic cancers continue to have a high unmet need
Challenges Autologous CAR T cell scalability Many patients fail CAR T treatment Allogeneic CAR T cells immune rejection limits persistence and efficacy Opportunity Known targets Known efficacy and safety bar Sana’s HIP CAR T platform can address challenges and exploit opportunities Hematologic cance
Slide 9: Sana's HIP platform can create a regenerative pipeline for allogeneic CAR T therapies
Sana’s HIP platform can create a regenerative pipeline for allogeneic CAR T therapies 1~450 doses assumes the middle dose in the ARDENT Phase 1 study and ~950 doses assumes an autoimmune dose consistent with public data on current autoimmune dose levels. Abbreviations: Cas12b, CRISPR associated prot
Slide 10: HIP CD19 CAR T cells demonstrate persistence and continued efficacy in humanized mice model
D55 D87 D75 D83 SC291 tumor control comparable at early timepoints to standard CD19 CAR T cells SC291 tumor control superior at later timepoints to standard CD19 CAR T cells SC291 controls tumors when animals are rechallenged with tumor HIP CD19 CAR T cells demonstrate persistence and continued effi
Slide 11: ARDENT trial will provide rapid insight into hypoimmune immune evasion
ARDENT trial will provide rapid insight into hypoimmune immune evasion SC291 is a mixture of HIP and non-HIP CAR T cells HIP CAR T cells survive after immune recovery T cells and NK cells recover Triple Knockout and CAR expression: 40-50% are fully modified cells 80-85% have all three gene knockouts
Slide 12: CAR T cells remain detectable in the majority of patients in ZUMA-1 trial
Locke et al. Lancet Oncology. 2019 CAR T cells remain detectable in the majority of patients with ongoing response treated in ZUMA-1 trial Patients with CAR gene-marked cells (%) Month n=37 n=37 n=33 n=34 n=34 n=33 n=31 n=32
Slide 13: SC291: Sana's CD19 HIP allogeneic CAR T
SC291: Sana’s CD19 HIP allogeneic CAR T Initial translational data show drug evaded immune detection as desired: Immune cells from patient one month after treatment did not recognize fully-edited SC291 cells Immune cells from patient one month after treatment recognized and killed partially-edited a
Slide 14: CAR T cells have the potential to transform autoimmune disorders
CAR T cells have the potential to transform autoimmune disorders like they have in blood cancers Depth of B-cell depletion correlates with clinical benefit CD19 CAR T cell therapy results in deep B-cell depletion Potential to deliver durable long-term remissions SC291 has the scale and potential pro
Slide 15: SC291 offers potential to address unmet need in autoimmune disorders
SC291 product candidate offers potential to address large unmet need in various incurable lifelong autoimmune disorders SC291: CD19 HIP allogeneic CAR T for treatment of autoimmune disorders MHC I MHC II TCRα + CD19 CAR + CD47 SC291 IND cleared to treat multiple autoimmune disorders under a single p
Slide 16: SC262: Targeting patients with inadequate response to CD19 therapy
SC262: Targeting growing population of patients with inadequate response to CD19 therapy 1US, EU5, and Japan. 2Clarivate DRG NHL Market Forecast Nov 2021; 2027 Forecast is 2L+ LBCL patients; internal analysis of secondary EPI data. 3Di Blasi et al. Blood.2022; DESCAR-T registry. ~65% ~35% ~12K ~12K
Slide 17: SC262: Licensed CD22 CAR produced strong clinical data in CD19 failures
2023 DAVA Frank/Stanford SC262 Goals: Submitted IND; clinical data in 2024 N=38 SC262: Licensed CD22 CAR produced strong clinical data in CD19 failures when part of autologous CAR T N=16 N=21 >50% 6-month CR rate in CD19 CAR failure DLBCL patients High rate of CRs in CD19 failure ALL patients ~80% p
Slide 18: SC255: Licensed BCMA CAR produced strong clinical data in myeloma
SC255: Licensed BCMA CAR produced strong clinical data in myeloma when part of autologous CAR T ORR: 98.9% ORR: 96% ORR: % Total N=101 sCR CR PR VGPR Prior CAR T n=12 No prior CAR T n=89 1 ~82.4% patients MRD negative at 12 months ~87.3% patients in CR/sCR with median follow-up ~1 year 2023 ASCO Nan
Slide 19: Type 1 diabetes represents a large unmet need
Disease caused by autoimmune destruction of insulin-producing beta cells in the pancreas; results in inability to control blood glucose Type 1 diabetes is a large unmet need with 1.9M patients in the U.S. and 2.4M in Europe2 Long-term complications: end-organ damage, including heart attack, stroke,
Slide 20: SC451: allogeneic iPSC-derived hypoimmune pancreatic islet cell therapy
Sana’s solution: SC451 is an allogeneic iPSC-derived hypoimmune pancreatic islet cell therapy Hu et al. Nature Biotechnology. 2023 Differentiate iPSCs into glucose-responsive islet cells that are hypoimmune + CD47 HLA I HLA II Hypoimmune iPSC-derived islet cells Create iPSC GMP master cell bank Star
Slide 21: HIP islet cells transplanted into NHPs
HIP islet cells transplanted into NHPs (10 months) D0 12 wks 28 wks 40 wks WT results (no survival after 1 wk) D0 1 wk n=1 HIP primary islet cells; n=1 WT primary islet cells. Survival of allogeneic hypoimmune pancreatic islet cells for 10+ months without immunosuppression Study design: NHP primary
Slide 22: Proprietary type 1 diabetes humanized mouse model
D0 D3 D7 D5 D9 No glucose control Patient T cells eliminate islet cells due to autoimmunity Sana’s immunology, gene modification, & stem cell capabilities create proprietary type 1 diabetes model Abbreviations: T1DM, type 1 diabetes mellitus Hu et al. Sci Transl Med. 2023 Patient with T1DM PBMCs Aut
Slide 23: HIP iPSC-derived islet cells evade autoimmune killing and control glucose
D7 D0 D23 D29 D13 HIP iPSC-derived pancreatic islet cells from patient with T1DM evade autoimmune killing and control glucose Abbreviations: BLI, bioluminescence imaging Hu et al. Sci Transl Med. 2023. BLI: Islet Survival C-peptide Glucose Control
Slide 24: HIP-modified allogeneic islet cells normalize glucose in diabetic NHP
HIP-modified allogeneic islet cells lead to normal blood glucose with no insulin and no immunosuppression in diabetic NHP Normal Hypoglycemia Impaired fasting glucose Hyperglycemia D78 Cell transplantation D85-D89 Reduce exogenous insulin D0 STZ D3 Start exogenous insulin Study Design (N=1) NHP prim
Slide 25: Primary human HIP islet cells transplantation in type 1 diabetes patients
Investigator sponsored trial Primary human HIP islet cells transplantation in type 1 diabetes patients Goal: Cell survival with no immunosuppression Goal: Data in 2023 and 2024 Insight for SC451 Path to potential clinical validation of hypoimmune islet cells in T1DM patients in 2023 Cell survival &
Slide 26: Build a best-in-class portfolio across cancers, autoimmune diseases, and beyond
Goal is to build a best-in-class portfolio to treat patients with a range of cancers, autoimmune diseases, and beyond 1Avezbakiyev et al. Blood. 2022 2Durie et al. The Oncologist. 2020 Unlocking the potential of our hypoimmune platform across multiple patient populations Value Time CD19 CD22 BCMA Au
Slide 27: Sana aspiration: Engineered cells as medicines
Sana aspiration: Engineered cells as medicines 1Does not incorporate hypoimmune genomic modifications Allogeneic CAR T Franchise Oncology: SC291, SC262, SC255 Autoimmune: SC291 Stem Cell-Derived Type 1 Diabetes: SC451 CNS: SC3791 Cell-specific delivery of genomic modification material Engineered cel
Slide 28: Thank You
Thank You Biotechnology"
Sana Biotechnology — Investor Presentation (December 2023) on 6ix