Sartorius Ag · XETR:SRT
Sartorius — Investor Presentation (September 2025)
21 slides from Sartorius's investor presentation, September 2025
Slide 1: Flexsafe Pro Mixer 5 L | 10 L | 20 L
Simplifying Progress Placeholder Image Flexsafe® Pro Mixer 5 L | 10 L | 20 L September 2025
Slide 2: Mixing Is Found at Various Stages of the Drug Manufacturing Process
Introduction Mixing Is Found at Various Stages of the Drug Manufacturing Process Upstream Sterile Mixing Filtration Storage Clarification Mixing Mixing UF/DF Storage Media Preparation Cell Culture Cell Harvest | Removal | Clarification Crossflow | Volume Reduction Downstream Sterile Mixing Filtratio
Slide 3: Challenges with Mixing at Low Volumes
Challenges Challenges with Mixing at Low Volumes Drug degradation Long mixing time to dissolve powders or highly viscous solutions Shear stress is present in almost all bioprocesses and is Achieving complete powder dissolution or homogeneity in known to play a role in degradation of various types of
Slide 4: Flexsafe Pro Mixer: One Single-Use Mixer for All Process Steps and Scales
Flexsafe® Pro Mixer Flexsafe® Pro Mixer: One Single-Use Mixer for All Process Steps and Scales One Single Mixing Technology from 5 L to 3,000 L 4 Flexsafe® Pro Mixer 5 L | 10 L | 20 L
Slide 5: Flexsafe Pro Mixer Hardware in Stainless-Steel or Plastic
Flexsafe® Pro Mixer Flexsafe® Pro Mixer Hardware in Stainless-Steel or Plastic Flexsafe® Pro Mixer HW in Stainless-Steel Flexsafe® Pro Mixer HW in Plastic 5 Flexsafe® Pro Mixer 5 L | 10 L | 20 L
Slide 6: Flexsafe Pro Mixer Single-Use Bags
Flexsafe® Pro Mixer Flexsafe® Pro Mixer Single-Use Bags 6 Flexsafe® Pro Mixer 5 L | 10 L | 20 L
Slide 7: An Ease to Use, Flexible and Reliable Solution
Flexsafe® Pro Mixer An Ease to Use, Flexible and Reliable Solution “Plug and mix” in less than 5 minutes Flexsafe® Pro Mixer Single-Use bags configurable for Impeller centered and stable by design liquid-liquid or powder-liquid mixing Monitor system parameters and control speed with remote O
Slide 8: A Mixing Technology Combining Powerful and Low Shear Mixing
Flexsafe® Pro Mixer A Mixing Technology Combining Powerful and Low Shear Mixing Powerful mixing enabled by Electromagnets in motor drive permanent magnet inside bag High rotation speed of the single-use magnetic impeller up to 750 rpm High torque up to 10 N.cm Low shear mixing is possible
Slide 9: Maximizing Buffers and Media Preparation with Efficient Mixing
Flexsafe® Pro Mixer Maximizing Buffers and Media Preparation with Efficient Mixing High torque and high speed allows fast powder dissolution in a few minutes DPBS 1X PowerCHO dissolution at 29,14 g/L 120% 120% Homogenity by conductivity Homogenity by conductivity 100% 100% measurements (%) measure
Slide 10: Ensuring Product Homogenization of Highly Viscous Solutions
Flexsafe® Pro Mixer Ensuring Product Homogenization of Highly Viscous Solutions Viscosity of a mAb solution during final formulation is in the range of 1- 100 cP depending on the concentration 1, 2, 3, 4, 5 Homogenization time in less than 1 min at different impeller speeds and volumes Capable
Slide 11: Simplifying Process Scaling from Early Drug Development Stages
Flexsafe® Pro Mixer Simplifying Process Scaling from Early Drug Development Stages Use the same mixing technology, the same 120 Flexsafe® film and the same material for all sizes 100 up to 3,000 L from process development to 95% Mixing time (sec) f(x) = 91.2518773384699 x^-0.563185809719197 commer
Slide 12: Satisfying Your Process Requirements with Configurable SU Bags
Flexsafe® Pro Mixer Satisfying Your Process Requirements with Configurable SU Bags Component Flexsafe® Pro Mixer bag 5 L and 10 L Flexsafe® Pro Mixer bag 20 L localization No component OR No component OR Openable 4" top port OR Up to 4 lines if no top port, Up to 2 lines if 4" Up to 4 line
Slide 13: Working Mixing Volume
Flexsafe® Pro Mixer Working Mixing Volume Residual volume by gravity draining Residual volume by pump draining Minimum Volume for temperature Min volume to stop mixing Minimum working volume Volume to Stop Sampling Bag adjustment volume Max fill volume sensing Bag Volum Test case e (L) (L) (L) (L) (
Slide 14: Flexsafe Pro Mixer for 5L, 10L, 20L with stainless steel Bag Holders
Flexsafe® Pro Mixer Flexsafe® Pro Mixer for 5L, 10L, 20L with stainless steel Bag Holders System 5L 10L 20L Total net weight (kg) 11,5 + 6,5 = 18 11,5 + 8,6 = 20,1 11,5 + 12,6 = 24,1 Dimensions (W x D x H) 468 x 452 x 439 468 x 452 x 475 468 x 452 x 540 Impeller speed (rpm) 10 – 750 10 – 750 10 – 75
Slide 15: Flexsafe Pro Mixer for 5L, 10L, 20L with plastic Bag Holders
Flexsafe® Pro Mixer Flexsafe® Pro Mixer for 5L, 10L, 20L with plastic Bag Holders System 5L 10L 20L Total net weight (kg) 11,5 + 2,9 = 14,4 11,5 + 4,4 = 15,9 11,5 + 8,7 = 20,2 Dimensions (W x D x H) 468 x 452 x 437 468 x 452 x 473 468 x 452 x 533 Impeller speed (rpm) 10 – 750 10 – 750 10 – 750 Tempe
Slide 16: Cleaning Agents for the Bag Holders
Cleaning Agents for the Bag Holders Cleaning Agents Compatibility 70% ethanol | 30% WFI STS & Plastic 70% isopropanol | 30% WFI STS & Plastic 1% hydrogen, 0.08% peracetic acid STS & Plastic 6% H2O2 STS & Plastic Alcohol (isopropanol, ethanol, methanol, in concentrations of 60–70%), STS & Plastic cit
Slide 17: Flexsafe Pro Mixer for 5 L, 10 L, 20 L Accessories
Flexsafe® Pro Mixer Flexsafe® Pro Mixer for 5 L, 10 L, 20 L Accessories Accessory Tubing Holder 5/8” Tubing Holder 7/16” Lab Cart Material Number FXC301595 FXC301596 FXC301598 Total weight (kg) 0,18 0,18 36 Dimensions (W x L x H) (mm) 70 x 115 x 67 70 x 115 x 67 578 x 1 149 x 1 021 17 Flexsafe® Pro
Slide 18: Recommended Bench Scale
Flexsafe® Pro Mixer Flexsafe® Pro Mixer for 5 L, 10 L, 20 L Recommended Bench Scale Combics 1 Complete Scale Model CAW1S1-150FE-I 1 - Load plate 2 - Adjustable feet 3 - Analysis device 4 - Display Combics 1 5 - General function keys 6 - Switch on / off 7 - Level indicator 18 Flexsafe® Pro Mixer 5 L
Slide 19: Recommended Bench Scale
Flexsafe® Pro Mixer Flexsafe® Pro Mixer 5 L | 10 L | 20 L Recommended Bench Scale Combics 1 all stainless-steel Model CAW1S1 (same as Palletank® Mixing) Platform 150FE-I 500 x 400mm | Capacity 150kg Resolution 5g 1 – Switch on / off 2 - Display 3 - General function keys 19 Flexsafe® Pro Mixer 5 L |
Slide 20: One Mixing Solution for All Mixing Steps and Scales
Flexsafe® Pro Mixer Flexsafe® Pro Mixer One Mixing Solution for All Mixing Steps and Scales Optimize Optimize Time Optimize Performance with Scalable Flexibility with with Powerful Solution 1 Mixer for All & Low Shear and Ease of Use 1 mixing Mixing technology up 1 motor for all Fast powder to
Slide 21: Thank You
Thank You