Inspire Medical Systems, Inc. · NYSE:INSP

Inspire Medical Systems — Wells Fargo Spotlight Series May 2023

25 slides from Inspire Medical Systems's conference presentation, May 22, 2023

  1. Slide 1: Wells Fargo Spotlight Series May 2023

    © Inspire Medical Systems, Inc. All Rights Reserved Wells Fargo Spotlight Series May 2023

  2. Slide 2: Inspire SleepSync™ Patient Journey

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire SleepSync™ Patient Journey

  3. Slide 3: Supporting Patients on their Path to Inspire

    © Inspire Medical Systems, Inc. All Rights Reserved Supporting Patients on their Path to Inspire 3 Implant Fine- tune ActivationInspire Advisor Care Program (ACP) DISE/ Prior Authorization Patient education using the InspireSleep.com website Community health talks Physician Consultations Awareness w

  4. Slide 4: Inspire Patient Journey

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire Patient T H E PAT I E N T J O U R N E Y Awareness Education Consultation Implant Life w/ Inspire Confirm Sleep Study Fine- tuneActivationImplantPrior AuthDISE Conduct Online Search Attend Appt. Schedule an Appt. with IS Dr. Obtain Updated S

  5. Slide 5: Patient Engagement Conversion Initiatives

    © Inspire Medical Systems, Inc. All Rights Reserved Patient Engagement Conversion Initiatives 5 Improving Patient Engagement Conversion Initiatives Increasing ENT Capacity to Further Grow Utilization SleepSync™ Patient Management System increase Utility • Digital scheduling has shown significant imp

  6. Slide 6: Inspire SleepSync™ Patient Management Platform

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire SleepSync™ Patient Management Platform

  7. Slide 7: SleepSync™ Digital Health Platform Accelerates Growth

    © Inspire Medical Systems, Inc. All Rights Reserved • Electronic medical records (Future) • Seep coaching, telemedicine, and efficient home sleep apnea testing © Inspire Medical Systems, Inc. All Rights Reserved INSPIRE CONFIDENTIAL SleepSync™ Digital Health Platform Accelerates Growth Enhanced by S

  8. Slide 8: Video

    © Inspire Medical Systems, Inc. All Rights Reserved8 Video

  9. Slide 9: Inspire SleepSync™ Patient Management Platform

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire SleepSync™ Patient Management Platform Automated, web-based monitoring of OSA therapy quality measures Inspire SleepSync™ Web PortalInspire Patient Remote Therapy quality measures are available on sleepsync.netCollects adherence data Patien

  10. Slide 10: More efficient support for Inspire patients

    © Inspire Medical Systems, Inc. All Rights Reserved More efficient support for Inspire patients Wireless and Automatic Therapy Monitoring Efficient Care Coordination Dynamic Patient Engagement

  11. Slide 11: Inspire Mechanism of Action; Drug-Induced Sleep Endoscopy (DISE)

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire Mechanism of Action Drug-Induced Sleep Endoscopy (DISE)

  12. Slide 12: Mechanism of Action - Stimulation Affects Multi-Level Collapse

    © Inspire Medical Systems, Inc. All Rights Reserved Mechanism of Action - Stimulation Affects Multi- Level Collapse (VIDEOS) Velopharynx Therapy OFF Velopharynx Therapy ON Tongue Base Therapy OFF Tongue Base Therapy ON Velo- pharynx Tongue- Base Safiruddin, ERJ 2014

  13. Slide 13: DISE examples of Palatal Concentric Collapse vs. AP Collapse

    © Inspire Medical Systems, Inc. All Rights Reserved DISE examples of Palatal Concentric Collapse vs. AP Collapse Includable: Velopharynx Anterior-Posterior collapse Excludable: Velopharynx Complete Concentric Collapse Conclusion: Patients with complete concentric collapse at the velopharynx can be i

  14. Slide 14: DISE example of CCC and Lateral Wall

    © Inspire Medical Systems, Inc. All Rights Reserved DISE example of CCC and Lateral Wall

  15. Slide 15: Inspire – Effect of BMI Increase on Outcomes

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire – Effect of BMI Increase on Outcomes • In one patient, the AHI decreased from 38/h to 10/h in the first month, increased to 30/h in the third month, and returned to 7.2/h at the 6- month sleep study. • This patient gained 11 kilos bodyweigh

  16. Slide 16: Inspire Technology Slides

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire Technology Slides

  17. Slide 17: Obstructive Sleep Apnea is a Serious and Chronic Disease

    © Inspire Medical Systems, Inc. All Rights Reserved Obstructive Sleep Apnea is a Serious and Chronic Disease OSA is Caused by a Blocked or Partially Blocked Airway • Blockage prevents airflow to the lungs • Results in repeated arousals and oxygen de-saturations • Severity of sleep apnea is measured

  18. Slide 18: Current Treatment Options Have Significant Limitations

    © Inspire Medical Systems, Inc. All Rights Reserved Current Treatment Options, Such as CPAP and Invasive Surgery, Have Significant Limitations Ina Uvulopalatopharyngoplasty (UPPP) Maxillomandibular Advancement (MMA) • Several variations of sleep surgery • Success rates vary widely (30% - 60%)1 • Irr

  19. Slide 19: A Strong Market Opportunity Exists for an Alternative to CPAP

    © Inspire Medical Systems, Inc. All Rights Reserved A Strong Market Opportunity Exists for an Alternative to CPAP that is Effective and Minimally Invasive  Sleep apnea affects +100 million people worldwide1  Approximately 17 million individuals in the U.S. with moderate to severe OSA • Annually, ~

  20. Slide 20: UAS is Safer than Traditional Sleep Surgery

    © Inspire Medical Systems, Inc. All Rights Reserved UAS is Safer than Traditional Sleep Surgery (UAS n=1,201; Palate n=3,364; MLS n=492) UAS has 4% risk of readmission vs ~15-20% UAS 2% complication rate vs 15-20% Nord et al, Comparison of Readmission and Complication Rates Between Traditional Sleep

  21. Slide 21: UAS has similar AHI improvement as CPAP

    © Inspire Medical Systems, Inc. All Rights Reserved UAS has similar AHI improvement as CPAP, and lower symptoms & disease burden Population: New UAS (n=117) and CPAP (n=110) pts Follow-up: 12 months Inclusion of both arms • Sleepiness Symptoms • AHI between 15-65 • Predominant OSA Statistically Matc

  22. Slide 22: Inspire Therapy is a Proven Solution for Patients with OSA

    © Inspire Medical Systems, Inc. All Rights Reserved Inspire Therapy is a Proven Solution for Patients with OSA Inspire System 1 2 3 Three implanted devices and patient remote: Pressure sensing lead: detects when the patient is attempting to breathe Neurostimulator: houses the electronics and battery

  23. Slide 23: Unified Patient Management Platform Inspire SleepSync™

    © Inspire Medical Systems, Inc. All Rights Reserved Unified Patient Management Platform Inspire SleepSync™ InspireSleep App Programmer Remote Inspire Cloud Inspire IV/V Stimulator 23

  24. Slide 24: Continuous Data Collection and Outcomes Monitoring

    © Inspire Medical Systems, Inc. All Rights Reserved Continuous Data Collection and Outcomes Monitoring • Collect real-world, international outcomes data • Eligibility – ALL patients receiving Inspire therapy • ADHERE Registry - 4,800 enrollments at 62 medical centers with enrollment goal of 5,000 pa

  25. Slide 25: Inspire Patient Experience Report - Safety

    © Inspire Medical Systems, Inc. All Rights Reserved 96.0% 96.5% 97.0% 97.5% 98.0% 98.5% 99.0% 99.5% 100.0% 0 3 6 9 12 15 18 21 24 27 30 33 36 39 42 45 48 51 54 57 Cu m ul at iv e Su rv iv al P er ce nt ag e Months After Implant 2018 2020 2019 2021 2022 Inspire Patient Experience Report - Safety Insp

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