Vicore Pharma Holding Ab · OMXSTO:VICO
Vicore Pharma Holding Ab — Investor Presentation (May 2025)
35 slides from Vicore Pharma Holding Ab's investor presentation, May 2025
Slide 1: Vicore Pharma
VICORE PHARMA Unlocking the potential of a new class of drugs – Angiotensin II type 2 receptor agonists (ATRAGs) May 2025
Slide 2: Disclaimers
Disclaimers This presentation may contain certain forward-looking statements and forecasts based on uncertainty, since they relate to events and depend on circumstances that will occur in the future and which, by their nature, will have an impact on Vicore Pharma’s business, financial condition and
Slide 3: Company overview
Company overview Vicore Vision Transform the lives of patients where modulation of the AT2 (angiotensin II type 2) receptor can play a central role in halting and reversing disease pathology Financials Publicly listed on Nasdaq Stockholm (VICO) and funded well past Phase 2b data $200m As of May 21,
Slide 4: Pipeline
Pipeline The company’s lead program, buloxibutid (C21), is a first-in-class oral small molecule angiotensin II type 2 (AT2) receptor agonist, which has received Orphan Drug and Fast Track designation from the United States Food and Drug Administration and is currently being investigated in the globa
Slide 5: IPF: A large and growing commercial opportunity with high unmet need
IPF: A large and growing commercial opportunity with high unmet need Large commercial market despite SoC shortcomings Majority of the market is not adequately addressed $6.2B+ Population in US and Europe Healthy lung Lung with fibrosis $4.2B ~250,000 $2.0B Only ~26% of US patients High discontinuati
Slide 6: Buloxibutid is a first-in-class AT2 receptor agonist with the potential to transform the IPF landscape
Buloxibutid is a first-in-class AT2 receptor agonist with the potential to transform the IPF landscape Phase 2b ASPIRE: confirming the Upstream MoA Exceptional clinical data clinical activity in a randomized, with strong preclinical data in the Phase 2a AIR trial placebo-controlled trial AT2 recepto
Slide 7: AT2R agonism is an upstream intervention driving tissue repair
AT2R agonism is an upstream intervention driving tissue repair • AT2R is constitutively expressed in the lung, primarily on alveolar epithelial type 2 cells – the “alveolar repair cell” Buloxibutid • AT2R activates tissue protective mechanisms via AEC2s, including anti-fibrotic effects ATRAGs • Bulo
Slide 8: AT2R is highly expressed in human lungs and specifically on precursor AEC2s
AT2R is highly expressed in human lungs and specifically on precursor AEC2s AT2R—but not AT1R—is expressed in the human lung1 AT2R is selectively expressed on AEC2s2 (AT1R blocker) + buloxibutid Single cell analysis shows AT2 AT2R expression receptor selectively on AEC2 in the lung buloxibutid AEC2
Slide 9: Alveolar epithelial cells are critical for healthy lung function
Alveolar epithelial cells are critical for healthy lung function Healthy alveolus • The alveolar epithelium is constantly exposed to damaging irritants in inhaled air AEC2 • AEC1 is the predominant alveolar cell type and is responsible for gas exchange Proliferation • AEC2 is a progenitor cell that
Slide 10: Buloxibutid is an oral, selective AT2R agonist that drives tissue repair via AEC2 precursor epithelial cells
Buloxibutid is an oral, selective AT2R agonist that drives tissue repair via AEC2 precursor epithelial cells Alveolar compartment in IPF Effects of buloxibutid Repeated Micro-injury Buloxibutid Increased AEC2 viability 1 & surfactant production 1 AEC2 dysfunction AEC2 Dysfunctional AEC2 TGFβ1 releas
Slide 11: Buloxibutid protects AEC2s and drives increased surfactant production
Buloxibutid protects AEC2s and drives increased surfactant production Surfactant protein expression increased by buloxibutid in Buloxibutid protects AEC2 cells against apoptosis1 ex vivo human IPF precision cut lung slices2 50 42% +120% % Increase vs Control 40 death 31% Cell death 30 29% +70% %%Cel
Slide 12: Buloxibutid reduces TGFβ1 and collagen in human IPF lung slices
Buloxibutid reduces TGFβ1 and collagen in human IPF lung slices TGFβ1 protein levels in PCLuS Collagen protein levels in PCLuS Human precision cut lung slices (PCLuS) ✱✱ 150 4000 ✱ ✱✱ Collagen-1a1 (pg/mL) (pg/ml) 3000 (pg/mL) TGFβ11(pg/mL) 100 Collagen-1a1 2000 -44% -61% TGF-β 50 1000 0 0 • Lung tis
Slide 13: Buloxibutid downregulates expression of EMT transcription factors in AEC2
Buloxibutid downregulates expression of EMT transcription factors in AEC2 SNAIL1 SNAIL2 Vehicle 0.1µM 1µM Vehicle 0.1µM 1µM Vehicle 0.1µM 1µM Vehicle 0.1µM 1µM buloxibutid buloxibutid buloxibutid buloxibutid • Primary AEC2 cultures established from normal surgically resected human lung • Buloxibutid
Slide 14: MMP-13 demonstrates antifibrotic activity and is crucial for lung repair in IPF
MMP-13 demonstrates antifibrotic activity and is crucial for lung repair in IPF Collagenase MMP dysregulation contributes to IPF Buloxibutid increased plasma MMP-13 in the pathogenesis Phase 2a AIR trial • MMP-13 is an enzyme able to cleave fibrillar collagens 250 and plays a significant role in the
Slide 15: Strong in vivo evidence for buloxibutid in pulmonary fibrosis
Strong in vivo evidence for buloxibutid in pulmonary fibrosis Bleomycin Monocrotaline Sugen-Hypoxia 6 15 * * 7 ** ** * * * Hydroxy proline (nM) 6 4 10 Fibrosis (%) Fibrosis (%) 5 2 5 4 0 0 3 Control BLEO buloxibutid C21 buloxibutid C21 Control MCT MCT MCT + + C21 Control SuHx SuHx buloxibutid C21 pr
Slide 16: Buloxibutid potently inhibits fibrosis in a human lung fibroblast assay
Buloxibutid potently inhibits fibrosis in a human lung fibroblast assay Human lung fibroblast assay methodology Impact on type III collagen biomarker PRO-C3 Mean±SEM (n=4) ****p<0.0001 (one-way ANOVA) Buloxibutid potently and dose-dependently inhibited PRO-C3, reflecting inhibition of type III colla
Slide 17: AT2R is selectively and constitutively expressed in the lung, in contrast to other IPF targets
AT2R is selectively and constitutively expressed in the lung, in contrast to the broader tissue expression of other IPF targets in development Target is upregulated in the lung in the IPF disease state IPF Target Expression in Healthy Tissue AGT2R LPAR1 αv β1 β6 SHH PDE4B IP-R Buloxibutid Admilparan
Slide 18: Buloxibutid has an extensive and robust safety database
Buloxibutid has an extensive and robust safety database, with over 350 patients dosed across nine completed clinical trials Buloxibutid has been tested extensively in the clinic, generating a robust safety database • Not including patients enrolled in the ongoing Phase 2b ASPIRE trial, a total of 36
Slide 19: AIR: An open-label Phase 2a trial of oral buloxibutid in treatment-naïve IPF patients
AIR: An open-label Phase 2a trial of oral buloxibutid 100 mg BID for up to 36 weeks in treatment-naïve IPF patients Patient Patient population population Clinic visits with FVC measurements Treatment-naïve IPF Week 2 4 6 9 12 15 18 21 24 28 32 36 patients with Screening period Follow-up period centr
Slide 20: AIR baseline patient characteristics are in line with other IPF trials
AIR baseline patient characteristics are in line with other IPF trials Key Characteristics AIR INPULSIS 1&2 (N=52) (N=1,061)1 Age (years) - Mean (SD) 67 (9) 67 (8) Males 77% 80% In line with other trials. Gender Females 23% 20% White 27% 57% Enrolled study population has disease progression comparab
Slide 21: Treatment emergent adverse events: buloxibutid shows better tolerability than SoC
Treatment emergent adverse events: buloxibutid shows better tolerability than SoC Comparison to SoC Buloxibutid Ph3 INPULSIS-1 Ph2a AIR 52-week treatment1 36-week treatment Nintedanib Placebo Buloxibutid n=309 n=204 n=52 Any AE 96% 89% 71% Common AEs (Non-exhaustive) Diarrhea 62% 19% 6% Good GI tole
Slide 22: Buloxibutid stabilizes and improves lung function over the 36-week AIR study
Buloxibutid stabilizes and improves lung function over the 36-week AIR study 400 *** 300 ** *** Buloxibutid 200 FVC change (mL) 28 ** mean +SEM 28 100 * 28 33 40 34 0 32 n=48 44 35 34 48 39 -100 Untreated patients1,2 -200 0 4 8 12 16 20 24 28 32 36 Week 1Noble et al. Eur Respir J. 2016 Jan; 47(1): 2
Slide 23: All subgroups show FVC stabilization and improvement over baseline at 36 weeks
All subgroups show FVC stabilization and improvement over baseline at 36 weeks 400 Change at week 36 vs baseline Mean FVC change at week 36 vs baseline Mean and median; ∆mL Subgroup (# patients); ∆mL Mean FVC change at +216 ml week 36 vs baseline (all) Probable UIP (n=18); 321 300 Median FVC change
Slide 24: Buloxibutid drives a significant increase in ppFVC
Buloxibutid drives a significant increase in ppFVC, consistent with its impact on absolute FVC Average ppFVC change from baseline at week 36 8 7.5% Buloxibutid also demonstrated a 6 median FVC change from baseline at week 36 of +2.2% 4 2 % 0 -2 -2.0% -4 Nintedanib2 -4.2% -6 Buloxibutid1 Untreated2 A
Slide 25: Buloxibutid outperforms historical standard of care and untreated decline at 36 weeks
Buloxibutid outperforms historical standard of care and untreated decline at 36 weeks Percentage of patients Percentage of patients with improved outperforming expected ∆FVC lung function (FVC) vs baseline 100% 70% 60% 50% 40% 30% 65% 75% 82% 20% 10% 25% 9% 0% Buloxibutid Buloxibutid vs Buloxibutid
Slide 26: Development of a Synthetic Control Arm analysis for the Phase 2a AIR study
Development of a Synthetic Control Arm analysis to contextualize buloxibutid’s effect in the Phase 2a AIR study • Age >= 40 years IPF Patient • FVC % predicted >= 60% • Follow-up time – 36 weeks External Control • FEV1/FVC >= 70% External Control Arm Generation • AIR – mean FVC change +23 ml Data •
Slide 27: IPF patients selected for the Synthetic Control Arm are highly matched to AIR patients
IPF patients selected for the Synthetic Control Arm analysis are highly matched to the Phase 2a AIR patient baseline characteristics Mean similarity p-value - 0.23 (SD=0.05) Note: Qureight analysis 27
Slide 28: A Synthetic Control Arm analysis demonstrates buloxibutid's robust treatment effect
A Synthetic Control Arm analysis demonstrates buloxibutid’s robust treatment effect Change in FVC in the Phase 2a AIR IPF trial compared to the 408 individual matched Synthetic Control Arms (SCAs) external control arm study (imputed data) generated by Monte Carlo cross validation 50 FVC AIR IPF stud
Slide 29: Buloxibutid increases collagenase MMP-13 and drives a trend of decreased TGFβ1
Buloxibutid increases collagenase MMP-13 drives a trend of decreased TGFβ1 Plasma TGFβ1 Plasma MMP-13 20 250 ** 16 200 *** Plasma MMP-13 (% of baseline) Plasma TGFβ1 ** 12 150 (ng/mL) 8 100 4 50 0 0 Baseline Week 12 Week 24 Week 36 Baseline Week 12 Week 24 Week 36 n=37 n=36 n=28 n=23 n=37 n=36 n=28
Slide 30: Phase 2b ASPIRE trial design
Phase 2b ASPIRE trial design A randomized, double-blind, placebo-controlled, parallel-group, multicenter, dose-finding trial IPF patients on stable nintedanib/SoC or not on SoC (no access, refused, intolerant or failed) 52-week treatment duration; N=270 (90 per arm) Study Assessment of efficacy, sa
Slide 31: ASPIRE is a global trial powered to demonstrate FVC stabilization
ASPIRE is a global trial powered to demonstrate FVC stabilization Large, conservatively powered study Global footprint with a broad range of countries Powered to detect FVC stabilization at 52 weeks 101 sites across 14 countries vs. conservative placebo arm assumption Transformative relative to stan
Slide 32: Vicore's partnership with Nippon Shinyaku for buloxibutid in Japan
Vicore’s partnership with Nippon Shinyaku for buloxibutid in Japan Partnership Overview Vicore Pharma and Nippon Shinyaku have entered an exclusive license agreement to develop and commercialize the drug candidate buloxibutid in Japan. Financial Terms Vicore has received an upfront payment of USD 10
Slide 33: Vicore has a platform of proprietary ATRAGs
Vicore has a platform of proprietary ATRAGs Buloxibutid – a first-in-class drug for rare lung diseases • Orphan drug status in IPF granted – Market exclusivity for 7 years in the US and 10 years in the EU. • Vicore has formulation and method-of-use IP granted in the US and EU covering buloxibutid, w
Slide 34: Strong leadership team with extensive industry experience
Strong leadership team with extensive industry experience Board of Directors AHMED MOUSA CHIEF EXECUTIVE OFFICER HANS SCHIKAN, PharmD – CHAIRMAN Experienced biotech executive with a background in 25 years management experience in global pharmaceuticals (e.g. molecular biology, law, and business deve
Slide 35: Contact us
Contact us Visiting addresses IR contacts www.vicorepharma.com Stockholm Copenhagen Boston AHMED MOUSA, CEO, ahmed.mousa@vicorepharma.com Kornhamnstorg 53 Agern Allé 5A One Broadway, 14th Floor info@vicorepharma.com HANS JEPPSSON, CFO, hans.jeppsson@vicorepharma.com SE-111 27 Stockholm DK-2970 Hørsh