Hyperfine, Inc. · NASDAQ:HYPR

Hyperfine — HealthCor Catalio Acquisition — SPAC Merger (September 2021)

50 slides from Hyperfine's SPAC merger presentation, Sep 27, 2021

  1. Slide 1: Hyperfine & Liminal Corporate Presentation

    Hyperfine & Liminal Corporate Presentation September 2021 1 © 2021 HYPERFINE

  2. Slide 2: Legal Disclaimer

    © 2021 HYPERFINE Legal Disclaimer This presentation is for informational purposes only and has been prepared to assist interested parties in making their own evaluation with respect to the proposed business combination (“Business Combination”) by and among HealthCor Catalio Acquisition Corp. (“Healt

  3. Slide 3: Legal Disclaimer: Forward-Looking Statements

    © 2021 HYPERFINE Legal Disclaimer Forward-Looking Statements This presentation includes “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. HealthCor’s, Hyperfine’s and Liminal’s actual results may differ from their

  4. Slide 4: Legal Disclaimer: No Offer or Solicitation

    © 2021 HYPERFINE Legal Disclaimer No Offer or Solicitation This presentation shall not constitute a solicitation of a proxy, consent or authorization with respect to any securities or in respect of the Business Combination. This presentation shall also not constitute an offer to sell or the solicita

  5. Slide 5: Hyperfine History, Vision and Overview

    Hyperfine History, Vision and Overview 5 © 2021 HYPERFINE

  6. Slide 6: The best way to predict the future is to make it

    © 2021 HYPERFINE The best way to predict the future is to make it” Jonathan M. Rothberg Vice Chairman and Founder Our mission: To provide affordable and accessible imaging, sensing, and guided robotic intervention to revolutionize healthcare for people around the world. Hyperfine and Liminal are exp

  7. Slide 7: Our mission

    © 2021 HYPERFINE Our mission Hyperfine began from our personal experience with the extraordinary power — and many challenges — of conventional MRI. Despite being one of the safest and most informative imaging modalities available, MRI is accessible to just a small percentage of patients. Globally, s

  8. Slide 8: Hyperfine Ecosystem

    Hyperfine Ecosystem 8 © 2021 HYPERFINE

  9. Slide 9: The Hyperfine ecosystem

    The Hyperfine ecosystem A full ecosystem solution: Hardware, software, consumables and applications powered by artificial intelligence Democratizing Imaging, Sensing and Guided Intervention to cover the care continuum Sense (in development) Image (FDA cleared) Intervene (in development) 9 © 2021 HYP

  10. Slide 10: Hyperfine has created the next generation of MRI

    © 2021 HYPERFINE Hyperfine has created the next generation of MRI MRI 1.0 1980 MRI 2.0 1990 MRI 3.0 FDA Cleared 2020 10

  11. Slide 11: Hyperfine has created the next generation of MRI: MRI 3.0

    © 2021 HYPERFINE Hydrocephalus Stroke Post-op Imaging Acute Mental Status Change Hyperfine has created the next generation of MRI MRI 3.0 - FDA Cleared 2020 Portable low-field MRI Patent protected noise cancellation system enables clinical-grade images FDA Cleared 2020 Reimbursed under existing imag

  12. Slide 12: Estimated $70+ billion opportunity across the ecosystem

    © 2021 HYPERFINE Estimated $70+ billion opportunity across the ecosystem Imaging Hospitals, Outpatient >100,000 Potential installation targets Sensing ICUs, Expanded Hospital, Surgical Centers, Outpatient, At-home ~4M Potential unit sales Guided Intervention Hospitals and Health Systems >50M Potenti

  13. Slide 13: Expected stakeholder benefits

    © 2021 HYPERFINE Patient • Safer than transport • Greater comfort and convenience • Faster diagnosis - Improved quality of care Physician • Expedite time to diagnosis and treatment • Discharge patients sooner Staff • Better incorporation into workflow by reducing transportation time and risk • Ergon

  14. Slide 14: Numerous challenges with traditional MRI today

    © 2021 HYPERFINE Numerous challenges with traditional MRI today during transport High cost limits accessibility Complex site requirements and upgrades Scheduling delays lead to longer length of stay Consumption of valuable personnel resources Risk of adverse events during transportation Maintaining

  15. Slide 15: Workflow benefits

    © 2021 HYPERFINE Workflow benefits MRI ordered Patient preparation Intra-hospital transfer to MRI MRI examination Intra-hospital transfer to unit Post MRI examination Traditional MRI workflow (25.8 hours) MRI ordered MRI examination Post MRI examination Hyperfine workflow (90mins, 94% reduction in t

  16. Slide 16: Bringing MRI to the patient

    © 2021 HYPERFINE Hyperfine addresses challenges of traditional MRI by bringing MRI to the patient Emergency Department Intensive Care Units and Operating Rooms Global Health 16 Safer and easier to use resulting in a faster time to diagnosis and treatment

  17. Slide 17: Hyperfine business model allows for potential widespread adoption

    © 2021 HYPERFINE Hyperfine business model allows for potential widespread adoption Subscription service includes: 4 contrast sequences (T1, T2, FLAIR, DWI with accompanying ADC map) Unlimited service and maintenance Unlimited user training Hyperfine Cloud PACS with unlimited Cloud archive Direct del

  18. Slide 18: Estimated Hyperfine economic benefits

    © 2021 HYPERFINE Estimated Hyperfine economic benefits Financial Benefits analysis based on data from Large Academic Medical Center *Assumes 2 Scanners - 1 in ED and 1 in ICU Cost Amount Saved ED throughput improvement $72,000 ICU LOS and Costs $225,000 Transport risks and costs $264,000 Annual Tota

  19. Slide 19: R&D Pipeline

    R&D Pipeline 19 © 2021 HYPERFINE

  20. Slide 20: Potential future applications and R&D engine

    © 2021 HYPERFINE 20 Stroke Hydrocephalus Potential future applications V2 Extremities Intra and Post Operative Expanded Addressable Market Improved usability Automated Stroke Detection Lower cost of goods Existing applications V1 C-spine Potential benefits: Innovative R&D engine designed to expand p

  21. Slide 21: Liminal will democratize brain sensing

    © 2021 HYPERFINE Liminal will democratize brain sensing After an accident Before and during surgery At a checkup While exercising Heart monitors are easy, accurate, and universal …but access to brain monitors is restricted. 21

  22. Slide 22: Liminal non-invasive brain vital sensor

    © 2021 HYPERFINE Liminal non-invasive brain vital sensor Breakthrough AEG Technology designed to unlock access to blood flow and pressure Non-Invasive Risk-free use on every patient to enable broader access and earlier diagnosis Continuous Trend Analysis Continuous sensing to build trends for data-b

  23. Slide 23: Brain-sensing clinical opportunities

    © 2021 HYPERFINE Brain-sensing clinical opportunities Intensive Care Unit Emergency Department Operating Room Outpatient & At Home - Hydrocephalus - Vasospasm - Stroke - Cerebral edema - Traumatic Brain Injury - Subarachnoid hemorrhage - Suspected seizures - Acute liver failure - Altered mental stat

  24. Slide 24: Building an ecosystem across the care continuum

    © 2021 HYPERFINE Hyperfine's goal is to build an ecosystem across the care continuum Powered by artificial intelligence Intervene Image Sense 24 Hyperfine aims to provide affordable care at the patient’s side... Precision when and where it matters

  25. Slide 25: Hyperfine Value Propositions

    Hyperfine Value Propositions 25 © 2021 HYPERFINE

  26. Slide 26: Portable MRI clinical use cases with current platform (V1)

    © 2021 HYPERFINE 26 Hyperfine portable MRI clinical use cases with current platform (V1) Intensive Care Unit - Acute Mental Status Change - Ataxia - Cerebral Edema - Cerebrovascular Disease - Cranial Neuropathy - Extra Ventricular Drain Placement - Follow-up Intracranial Hemorrhage - Follow-up Ische

  27. Slide 27: Image quality progression over time

    © 2021 HYPERFINE 27 Image quality progression over time 4 contrasts 104x 178x 220x 260x 1x 74x 94x 2016 2017 2018 2015 2019 2020 DL • Latest sequence developments and recon continue to improve • DL* reconstruction FDA submission in Q3 2021 • T1, T2 and FLAIR approaching 1.5T image quality 2021 *DL=D

  28. Slide 28: Image quality progression: Deep Learning Reconstruction

    © 2021 HYPERFINE Image quality progression over time: Deep Learning Reconstruction 28 Video link

  29. Slide 29: Video Link

    © 2021 HYPERFINE Video Link

  30. Slide 30: Value Prop: Acute Mental Status Change ICU

    © 2021 HYPERFINE Value Prop | Acute Mental Status Change ICU Point of Care/Bedside Imaging • Swoop for Patients with AMS Changes • Elimination or reduction of patient transport to MRI • Elimination or reduction of patient adverse events associated with transport • Cost reduction associated with staf

  31. Slide 31: Diagnosing and Treating Acute Change in Mental Status in an ICU

    © 2021 HYPERFINE Diagnosing and Treating Acute Change in Mental Status in an Intensive Care Unit with the Hyperfine Swoop™ The Swoop™ System allows rapid bedside diagnosis and treatment without patient transport risks and without changing conventional MRI and CT system schedules. Additionally, the S

  32. Slide 32: Acute change in mental status in critical situations

    © 2021 HYPERFINE Acute change in mental status in critical situations • Intensive Care Units • Emergency Departments • Hospital Step-down units Patients in critical situations require immediate assessment of their mental status via direct imaging in order to establish the etiology of the change. The

  33. Slide 33: Value Prop: Cerebral Infarction ED

    © 2021 HYPERFINE Value Prop | Cerebral Infarction ED Stroke/AMS Change Point of Care Imaging • Reduced Time to Clinical Decision/Diagnosis • Elimination of wait time for High Field MRI • Potential Elimination/Reduction in Excess Radiation and/or Contrast Administration with CT • Potential life savin

  34. Slide 34: Acute presentation with vague symptoms

    © 2021 HYPERFINE Acute presentation with vague symptoms • Emergency Departments • Urgent Care Centers Patients presenting with vague symptoms require diagnoses to be made to allow appropriate management. If an acute issue is determined the patient can be treated and triaged accordingly. If a signifi

  35. Slide 35: Value Prop: Pediatric Hydrocephalus

    © 2021 HYPERFINE Value Prop | Pediatric Hydrocephalus ED Hydrocephalus Point of Care Imaging • Elimination of CT Radiation for Patients • Elimination of wait time for High Field MRI in ED • Clinical Decision on Shunt function and patient care • Elimination of ED as an entry point for the patient/cli

  36. Slide 36: Child with prior ventricular shunt

    © 2021 HYPERFINE Child with prior ventricular shunt • Neurosurgery Clinics • Emergency Departments • Urgent Care Centers Children with known ventricular shunts may present with a combination of symptoms – headaches, nausea and vomiting. While these may be benign (most likely are) the possibility of

  37. Slide 37: Bill and Melinda Gates Foundation Expands Partnership

    © 2021 HYPERFINE Bill and Melinda Gates Foundation Expands Partnership Grant 1 - March 2020 - $1.61 Million grant for 20 Hyperfine Scanners ● Child brain development (volume) ● Neonatal Hypoxic Ischemic Encephalopathy (birth asphyxia) Grant 2 - September 2021 - $3.3 Million expansion grant to: ● fiv

  38. Slide 38: BMGF Site list

    © 2021 HYPERFINE High Income Country (HIC) 1. King’s College London #1 2. King’s College London #2 3. Cardiff University 4. NIH (Peter Basser) 5. University of British Columbia (Shannon Kolind) 6. Max Planck Institute 7. Boston Children’s Hospital 8. Children’s Hospital of Philadelphia 9. UC San Fra

  39. Slide 39: Expert User Insights

    Expert User Insights 39 © 2021 HYPERFINE

  40. Slide 40: Expert Panel

    © 2021 HYPERFINE Dr. Richard L. and Gertrude W. Fruin Professor of Neurosurgery at the University of Illinois College of Medicine; Chair, Department of Neurosurgery, UI Health; Chief of Neurovascular Section Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neuroscience; Cha

  41. Slide 41: Intracerebral hemorrhage detection with Swoop

    © 2021 HYPERFINE Kevin N. Sheth Yale New Haven Hospital Intracerebral hemorrhage (ICH) detection with Swoop ● Data collected from July 2018 to March 2020 ● 144 exams ○ 56 ICH ○ 48 acute ischemic stroke ○ 40 healthy controls ● 130/144 correctly classified as positive or negative ICH (90.3% sensitivit

  42. Slide 42: ICH at 0.064T vs conventional imaging modalities

    ICH at 0.064T vs conventional imaging modalities (CT or 3T MRI) © 2021 HYPERFINE

  43. Slide 43: Value Prop: Post Surgical Imaging

    © 2021 HYPERFINE Value Prop | Post Surgical Imaging Dr. Murat Gunel Yale 43 Postoperative Imaging Rule Out post op Concerns/Complications Post Surgical Diagnostic Check Elimination of Next Day MRI/Patient Transport Potentially Reduce Level of Care post-op/step down

  44. Slide 44: Immediate Assessment of Post-Operative Patient in the OR

    © 2021 HYPERFINE Immediate Assessment of Post-Operative Patient in the Operating Room with the Hyperfine Swoop™

  45. Slide 45: First OR Case at Yale

    © 2021 HYPERFINE First OR Case at Yale PRE-OP (High Field) POST-OP (Hyperfine) POST-OP (CT)

  46. Slide 46: Platform for stroke diagnosis

    © 2021 HYPERFINE Hyperfine provides compelling platform for stroke diagnosis 15 million people worldwide suffer a stroke annually Stroke is the 2nd leading cause of death globally 87% strokes are ischemic strokes MRI scans are better at detecting ischemic stroke damage compared to CT scans MRI use f

  47. Slide 47: Diagnosing and Treating Stroke Onset Greater Than 6 Hours

    © 2021 HYPERFINE IV tPA Diffusion greater than FLAIR without LVO Diagnosing and Treating Stroke Onset Greater Than 6 Hours (or Unknown) with the Hyperfine Swoop™ Stop and treat Thrombectomy Diffusion greater than FLAIR with LVO Diffusion and FLAIR imaging Diffusion equals FLAIR Observe and follow-up

  48. Slide 48: Stroke diagnosis confirmed

    © 2021 HYPERFINE Stroke diagnosis confirmed 62 year old male Presented with new left sided weakness and tremor FLAIR T2 DWI ADC 48

  49. Slide 49: Appendix

    Appendix HYPERFINE. © 2021 HYPERFINE

  50. Slide 50: Demo @ Your Door

    Demo @ Your Door © 2021 HYPERFINE

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